Protein Alignment Ptpmeg and ptprsa

DIOPT Version :9

• Sequence 1: NP_001163309.2
• Gene: Ptpmeg / 38059
• FlyBaseID: FBgn0261985
• Length: 974
• Species: Drosophila melanogaster
• Sequence 2: XP_021325154.1
• Gene: ptprsa / 140820
• ZFINID: ZDB-GENE-020107-3
• Length: 1945
• Species: Danio rerio
• Alignment Length: 1031
• Identity: 223/1031 - (21%)
• Similarity: 342/1031 - (33%)
• Gaps: 390/1031 - (37%)

  Fly    86 VVRW---------VDAQ---KQFKKQCSSVSLDNDAVPL---------LEFRVK---------FF 120
            ::||         ::.|   .||.::        |..||         ||:.:.         |.
Zfish   847 IIRWQPPDYVAPGLEVQGYRLQFGRK--------DVNPLATLEFGPQELEYSISNIHRGATYIFK 903

  Fly   121 VSDPSR--LQEEFTRYQFYLQIKRNILLG--KLPCSSNTQCLLASYT----VQSE----LGDFNA 173
            ||..|:  ..||.|:   .|::...:..|  ::...||..|....::    |.:|    :.::..
Zfish   904 VSAKSKSGFGEEATQ---ELRVPEEVPRGYPQITEGSNITCCSVQFSWLPPVLAERNGAITEYTL 965

  Fly   174 LEHQPGYLSGMQLLCDQTTEAERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRATDSN 238
            ...:.|.:||.:.|                    :||||.....|...:...:|.:.:...|
Zfish   966 SYQEAGTISGPKEL--------------------RLPADENSYILNSLRPNAVYDVKIRAHT--- 1007

  Fly   239 GKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSFKRKDFFIQLRREPS-----ENYDTLLGFGM 298
                     :||...:...::..|.::...|.     ::|.::|..:.:     :.||
Zfish  1008 ---------SVGPGPYSPPIQYRTVAYEADVP-----RNFTVKLVTKTTVLLSWKFYD------- 1051

  Fly   299 SSHKHAKALWKSCVEHHSFFRLKR--PHRLSRFLNISLGSKFYYSGRTELQAVQESKQRGRIHK- 360
                 ::..:|..:|:|   |.|.  ..|:::.|..:|.....|..|.   :.|:|...|..||
Zfish  1052 -----SRFPYKCTIEYH---RQKSDIDARMTKTLITNLRPNTTYEFRI---SCQDSSDGGPKHKL 1105

  Fly   361 -------VFVRSP--------------------SKRLLGAAGGVGTSGSSGGTPM---------- 388
                   :.:|.|                    :|.|:.|...|......|..||
Zfish  1106 VARTAPHIQIRKPELDLKRESESTLTIVFPPLETKDLIKAIYVVVVPLKKGKGPMRHIKSPDELD 1170

  Fly   389 -QQHSGSESANSHNNGKPAGAGTILTITKTSRPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDVG 452
             ::..|......|::|          .|:..:..|.|
Zfish  1171 LEELLGERRLGLHHSG----------TTRQLKQVDGK---------------------------- 1197

  Fly   453 FIEQCTRRFESAS--PSPMPPAYSSGQH-----------------------------------SP 480
                  |.:.:||  ||.|||:::.|..                                   ||
Zfish  1198 ------RPYIAASFKPSSMPPSFTLGNQMMYGSFENRALDRGQEYVLFILAELNTTGVKAFVSSP 1256

  Fly   481 ILLPTTIADAVGHQQPESGSD------------------LITIRLQADEQGRYGFNVKGGVDLSL 527
            ...|....| :..|..|||.|                  :|.|.|..:               |.
Zfish  1257 YTDPIMAPD-LDPQPLESGGDGLIWVVGPVLAVVFIICIVIAILLYKN---------------SK 1305

  Fly   528 PVQVSKVVPHTPADRCTPRVCEGDEVLMINGRDV--HGLRHEQVVAMIRDCRHQASGELLLTVRP 590
            | ..||.....|..:|           ::|..|:  |   |......:|....|.....|.:  |
Zfish  1306 P-DSSKRKESEPRTKC-----------LLNNADITPH---HPTDPVEMRRINFQTPDSGLSS--P 1353

  Fly   591 QRSAPLLLEEEPLYQYVPESDEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPD 655
            ...|....|....:..:|.| |:..|:.||..           :|.|   .|..:||.:   :|.
Zfish  1354 VSEAGFDYESMMNHPPIPIS-ELAEHTELLKA-----------NDNL---KLSQEYESI---DPG 1400

  Fly   656 LAIT--EARKPANAPKNRYRDISPYDCTRVSL--VNSLTG-DYINANYVNMEIPGG--AVNRYIA 713
            ...|  .:....|.|||||.::..||.:||.|  :..:|| ||||:||::     |  ..|.|||
Zfish  1401 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILAPIEGITGSDYINSNYID-----GYRKQNAYIA 1460

  Fly   714 TQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEE----LQLAEGFSVRCLS 774
            |||||..|..||||||.::.:..:||:|.:.|..|.||.||||..|.|    :|:....::
Zfish  1461 TQGPLPETFGDFWRMVWEQRAATVVMMTRLEEKSRIKCDQYWPSRGTETYGMIQVTLLDTI---- 1521

  Fly   775 EKPDETGSFVFREFVL--KDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQE 837
                |..:|..|.|.|  ....|:|.:...|:.|||||.||..|..||.|..||:.
Zfish  1522 ----ELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKT--------- 1573

  Fly   838 IEESLKQVRLMDADADADENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAG 902
                                              ..|.|.               .|:|.|||||
Zfish  1574 ----------------------------------CNPPDA---------------GPIIAHCSAG 1589

  Fly   903 IGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA 958
            :||||..|::|..|..::..:.|.....|..||.||..|||...||.|:.:.:..|
Zfish  1590 VGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRSQRNYMVQTEDQYSFIHDALLEA 1645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	34/187 (18%)
		FERM_N	38..102	CDD:286467	5/27 (19%)
		FERM_M	125..232	CDD:278785	21/118 (18%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	13/98 (13%)
		FA	333..369	CDD:285894	10/63 (16%)
		PDZ_signaling	502..589	CDD:238492	16/88 (18%)
		Y_phosphatase	666..955	CDD:278528	99/299 (33%)
		PTPc	668..955	CDD:238006	98/297 (33%)
ptprsa	XP_021325154.1	I-set	31..122	CDD:254352
		Ig2_RPTP_IIa_LAR_like	150..233	CDD:319301
		Ig3_RPTP_IIa_LAR_like	257..325	CDD:143216
		FN3	330..419	CDD:238020
		FN3	426..518	CDD:238020
		FN3	523..612	CDD:238020
		FN3	620..713	CDD:238020
		fn3	721..819	CDD:306538
		FN3	831..919	CDD:238020	17/82 (21%)
		fn3	931..1015	CDD:306538	18/115 (16%)
		FN3	1028..1101	CDD:238020	17/95 (18%)
		PTPc	1415..1644	CDD:238006	98/299 (33%)
		PTPc	1676..1935	CDD:214550

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910