DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and ptprfa

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_021332435.1	Gene:	ptprfa / 140819	ZFINID:	ZDB-GENE-020107-2	Length:	1918	Species:	Danio rerio

Alignment Length:	1163	Identity:	240/1163 - (20%)
Similarity:	380/1163 - (32%)	Gaps:	478/1163 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 GDVVRW------VDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKR 142
            |.:||:      |..:.|.:.:...:..|          |..:|.:.   .|::|.|..:  :|.
Zfish   646 GSIVRYSLAYQAVSGEDQERHEVKDIPAD----------VSSYVLEG---LEKWTEYTVW--VKA 695

  Fly   143 NILLGKLPCSSNTQC-----LLASYTVQSELGDFNAL-----------EHQPGYLSGMQLLCDQT 191
            :..:|..|.|.:|:.     :..:...:.|:.:.|:.           :.|.|::.|.|::..:.
Zfish   696 HTDVGPGPESGSTRIRTQEDVPGAPPRRVEVDNINSTALRVSWKPPLQQKQHGHIRGYQVVYSRL 760

  Fly   192 TEAERKVGELHKLHRGQ-------LPADAEYNYLEHAKRLELYGIDLHRAT---DSNGKELQLGV 246
            ...|         .|||       || :|:...:........|.:.:...|   |....:.:: |
Zfish   761 ENGE---------PRGQPIILDVALP-EAQEAVISGLLPETTYSVTVAAYTTKGDGARSKAKV-V 814

  Fly   247 SAVGLLVFQHSLRVNT-------FSW---SKMV------KVSFKRKDFFIQLRRE--PSENYDTL 293
            :..|.:..:.::.::|       ..|   .:||      ::.:||::..|...|:  .::::.|:
Zfish   815 TTTGAVPGKPTMIISTTIGNTALIQWQPPKEMVGELMGYRLRYKREEEDIYTVRDFRRTDDHFTV 879

  Fly   294 LGFGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSRFLNISLGSKFYYSGRTELQAVQESKQRGRI 358
            .|.    ||.|..::|.|.::.:                  |:...||  .|:...::
Zfish   880 TGL----HKGATYIFKLCAKNRA------------------GNGEEYS--KEISTPED------- 913

  Fly   359 HKVFVRSPSKRLLGAAGGVGTSGSSG--GTPMQQHSGS--------ESANSHNNGKPAGAGTILT 413
                |.|...:.|...|...|:....  ..|:.:.:|.        ...|||.|.....|.|.:|
Zfish   914 ----VPSSYPQNLKVVGLTTTTTKLAWDPPPLPERNGKIVRYVVVYRDINSHQNQTNGTADTEMT 974

  Fly   414 ITKTSRPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSGQH 478
            | :..:|                     ...|||::         |.|......|:.|:..|...
Zfish   975 I-QGLKP---------------------DTTYDIRV---------RAFTGKGGGPISPSIQSRTM 1008

  Fly   479 S------------------PILLPTTIADAVGHQQP----------ESGSDL---ITIRLQADEQ 512
            |                  .:||...:.:....|.|          |...||   :..|||.|..
Zfish  1009 STSMPEFTKNFGVKAVMKTSVLLTWEVPETYKSQVPFKILYNQQSVEVQGDLKRKLITRLQPDTD 1073

  Fly   513 GRYGF------NVKGGVDLSLPVQVSK-------------------------------------- 533
              |.|      |..||:...:.::.:.
Zfish  1074 --YSFVLMSRGNSAGGLQQQVSIRTAPDLFTTKPAHQKLDPEEGGKLAITLPEVHNSALVRWFYI 1136

  Fly   534 -VVPHTPADRCTPRVCEGDE-----VLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQR 592
             |||.||:   |.|..|..|     .||.|.||          |.:|..|.|....|    ||..
Zfish  1137 VVVPVTPS---TLRHWENPEDIDLDELMGNNRD----------AAVRRRRRQTQDFL----RPYI 1184

  Fly   593 SAPLLLEEEPLYQYVPESDEIG---SHSN-------------------LLDGDALFTQS------ 629
            :|.|        :.:||...:|   ::||                   |.|.|:.||.|
Zfish  1185 AAKL--------ESLPERFVLGDEKTYSNYYNKPLPGQQQYRTFILAALKDRDSTFTVSPFSEPM 1241

  Fly   630 LLLLSDGLA-----------SGALLA--------------------------------------- 644
            ::.|..|::           .|.:||
Zfish  1242 MVKLHSGMSRHVEDPEMLWVMGPVLAVVLIIIIVIAILLFKSKQERKRTSPSAKDEHSAGVKDHL 1306

  Fly   645 -------------QYELM------------YRKNPDLAIT---------------------EARK 663
                         .|:..            .|::|.:::.                     |:..
Zfish  1307 LAHSSDPVEMRRLNYQTQGSSAFNCPSTSRMREHPPVSVCALADHIERLRANDSLRFSQEYESVD 1371

  Fly   664 P------------ANAPKNRYRDISPYDCTRVSL--VNSLTG-DYINANYVNMEIPGG--AVNRY 711
            |            .|.|||||.::..||.:||.|  |:.:.| ||||.||::     |  ..|.|
Zfish  1372 PGQQFTWENSNLEVNKPKNRYANVIAYDHSRVVLTPVDGVPGSDYINGNYID-----GYRKQNAY 1431

  Fly   712 IATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEE----LQLAEGFSVRC 772
            |||||||..|.:||||||.::.:..:||:|.:.|..|.||.||||..|.|    :|::...:|
Zfish  1432 IATQGPLPETLSDFWRMVWEQRTSTIVMMTRLEEKSRVKCDQYWPSRGTETYGMIQVSMLDTV-- 1494

  Fly   773 LSEKPDETGSFVFREFVL--KDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLL 835
                  |..::..|.|.|  ....|:|.:...|::|||||.||..|...|.|..||:|
Zfish  1495 ------ELATYSVRTFALYKNGSSEKREVRQFQFMAWPDHGVPEYPTPILAFLRRVKA------- 1546

  Fly   836 QEIEESLKQVRLMDADADADENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCS 900
                                                ..|.|.               .|::||||
Zfish  1547 ------------------------------------CNPPDA---------------GPMVVHCS 1560

  Fly   901 AGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAA 958
            ||:||||..|::|..|..|:..:.|.....|..||.||..|||...||.|:.|.:..|
Zfish  1561 AGVGRTGCFIVIDAMLERMKHEKSVDIYGHVTCMRSQRNYMVQTEDQYIFIHEALLEA 1618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	30/176 (17%)
		FERM_N	38..102	CDD:286467	5/23 (22%)
		FERM_M	125..232	CDD:278785	22/129 (17%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	20/114 (18%)
		FA	333..369	CDD:285894	6/35 (17%)
		PDZ_signaling	502..589	CDD:238492	29/139 (21%)
		Y_phosphatase	666..955	CDD:278528	101/299 (34%)
		PTPc	668..955	CDD:238006	100/297 (34%)
ptprfa	XP_021332435.1	I-set	33..124	CDD:254352
		Ig2_RPTP_IIa_LAR_like	152..232	CDD:319301
		Ig3_RPTP_IIa_LAR_like	256..324	CDD:143216
		FN3	329..418	CDD:238020
		FN3	425..517	CDD:238020
		FN3	522..610	CDD:238020
		fn3	618..705	CDD:306538	14/73 (19%)
		FN3	720..816	CDD:238020	17/106 (16%)
		FN3	821..902	CDD:238020	16/102 (16%)
		FN3	919..1007	CDD:238020	22/118 (19%)
		FN3	1017..1086	CDD:238020	14/70 (20%)
		PTPc	1388..1617	CDD:238006	100/299 (33%)
		PTPc	1678..1908	CDD:238006
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910