DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and AgaP_AGAP001109

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_322055.4	Gene:	AgaP_AGAP001109 / 1282054	VectorBaseID:	AGAP001109	Length:	709	Species:	Anopheles gambiae

Alignment Length:	832	Identity:	200/832 - (24%)
Similarity:	293/832 - (35%)	Gaps:	254/832 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 YLEH---AKRLELYGIDLHRATDSNGKELQLG---------VSAVGLLVFQHSLRVNTFSWSKMV 269
            |.:|   .:|..|||.|  ..|:....||:.|         .|...:.:|..:|.   :..:...
Mosquito    54 YEQHELIRQREGLYGFD--PQTEPLRTELETGKFTILPGRDASGAAIALFTANLH---YPMTVTH 113

  Fly   270 KVSFKRKDFFIQLRREPSENYDTLLGF--GMSSHKHAKALWKSCVEHHSFFRLKRPHRLSRFLNI 332
            |.:.:...:.:.:..:.||.....|.|  .||:.|::...:....:..:..:...|.||.:.|.:
Mosquito   114 KTTLQGVVYQLDVALQSSETQKAGLVFIYDMSTSKYSNFDYDLSQKILTLLKGGYPARLKKVLIV 178

  Fly   333 SLGSKFYYSGRTE-LQAVQESKQRGRIHKVFV-----RSPSKRLLGAAGG--------------- 376
            :  :..::....: |:.....|.|.|:..|.:     ..|.:.|....||
Mosquito   179 T--APLWFKAPFKILRLFVREKLRERVFTVSIPQLSLHVPRESLPVRLGGTLEVDHSSWLLHCYK 241

  Fly   377 ---------VGTSGSSGGTPMQQHSGSESANSHNNGKP----AGAGTILTITKTSRPHDNKVTSK 428
                     :.|:|.....|....|.|...|......|    ||...|...|.|...| :.:|..
Mosquito   242 SMTNREDEIIATAGQQQQQPQTSQSNSTDLNGVIGASPVMGSAGIAAIAAGTGTLDTH-HSLTGV 305

  Fly   429 EADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMP-----------PAYSSGQHSPIL 482
            ....:               :||.|:.....|....:.:.:.           ....:.||
Mosquito   306 VGSEL---------------VDVEFVNSHNHRVSPENGAEVEDHLNVEDISNIAVVGANQH---- 351

  Fly   483 LPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPRV 547
            ||...|..||||...:.|:|.|....:....  ||                      :|..:...
Mosquito   352 LPANHAGHVGHQNHHTTSELWTENPPSSASS--GF----------------------SDDDSLAG 392

  Fly   548 CEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLLLEEEPLYQYVPESDE 612
            .|||...:           ||:|.|:|                                  |..:
Mosquito   393 AEGDPKTI-----------EQIVQMVR----------------------------------ERGK 412

  Fly   613 IGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISP 677
            :|                           |:.:|..:..:.||...|.|:...|..||||.|:..
Mosquito   413 MG---------------------------LIREYTEIKARAPDGTFTHAKLRNNLAKNRYTDVLC 450

  Fly   678 YDCTRVSL---VNSLTGDYINANYVNMEIPGG--AVNRYIATQGPLASTTTDFWRMVQQESSHLL 737
            ||.:||.|   .:....||||||:|:     |  ..|.||:|||||..|:.||||||.::...|:
Mosquito   451 YDHSRVVLSQEEDDPATDYINANFVD-----GYKQKNAYISTQGPLPKTSYDFWRMVWEQHCLLI 510

  Fly   738 VMLTTVMESGRQKCHQYWPVTGEELQLAE--GFSVRCLSEKPDETGSFVFREFVLKDKHEQRHIH 800
            ||.|.|||.||.||.|||..|  |..|||  .|.:|.:|.:.:|..:.|..|.......|.|.:.
Mosquito   511 VMTTRVMERGRAKCGQYWEPT--EGGLAEYGSFRLRTMSIETNEDYTVVELEIRNIKTDEVRCVS 573

  Fly   801 HMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGLMRERK 865
            |.|:.:|||:.|||.....|.|.:|.|           |:..:.||.: .|..|....|
Mosquito   574 HWQFTSWPDYGVPSSAKAMLNFLQRAR-----------EKQAEMVRAL-GDLWAGHPRG------ 620

  Fly   866 CAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDI 930
                                       ||::|||||||||||..|.:|..::.:   |.|...||
Mosquito   621 ---------------------------PPIVVHCSAGIGRTGTFITLDICISRL---EDVGTADI 655

  Fly   931 ---VRTMRDQRACMVQNVSQYRFVCECICAAYMKISRS---SAAIN--DDED 974
               |..:|.|||..:|...||.| |......| .:|||   |..::  ||.|
Mosquito   656 KGTVEKIRSQRAYSIQMPDQYVF-CHLALIEY-ALSRSMLQSVDLSEFDDRD 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	7/17 (41%)
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785	7/17 (41%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	19/104 (18%)
		FA	333..369	CDD:285894	6/41 (15%)
		PDZ_signaling	502..589	CDD:238492	13/86 (15%)
		Y_phosphatase	666..955	CDD:278528	108/298 (36%)
		PTPc	668..955	CDD:238006	107/296 (36%)
AgaP_AGAP001109	XP_322055.4	CRAL_TRIO	83..227	CDD:279044	24/148 (16%)
		PTPc	414..685	CDD:214550	115/353 (33%)
		PTPc	442..685	CDD:238006	107/298 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910