DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and AgaP_AGAP012185

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_320350.4	Gene:	AgaP_AGAP012185 / 1280503	VectorBaseID:	AGAP012185	Length:	1648	Species:	Anopheles gambiae

Alignment Length:	896	Identity:	236/896 - (26%)
Similarity:	349/896 - (38%)	Gaps:	255/896 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PELARDKKTPQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGD 85
            |...:.|.|..:.....|..||.......|:::.:|.:||:.|...|.:.|:|||||.: ....|
Mosquito    22 PSTPKKKPTNSKAALAKVTLLDGSILEVTIDRKCRGRDLLNSVCAGLNILEKDYFGLTY-HTAND 85

  Fly    86 VVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKLP 150
            ...|:|.::...|...|...|      |.|.|||:..:|::|||:.|||...||::.:||.|:||
Mosquito    86 PRTWLDLERPVTKFFRSDPWD------LSFEVKFYPPEPAQLQEDITRYHLCLQVRNDILEGRLP 144

  Fly   151 CSSNTQCLLASYTVQSELGDFNALEHQP-GYLSGMQLLCDQTTEAERKVGELHKLHRGQLPADAE 214
            ||..|..||.||.|||||||::..|.:. .||...::..:||.|...||.:|||.|:.|.||:||
Mosquito   145 CSFVTHALLGSYLVQSELGDYDPAEMKDRSYLKDFKIAPNQTPELLDKVIDLHKTHKSQTPAEAE 209

  Fly   215 YNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSFKRKDFF 279
            .:|||:||:|.:||:|||.|.||.|.::.|||.|.||||::..||:|.|:|.|::|:|:||.:|:
Mosquito   210 LHYLENAKKLAMYGVDLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKRNNFY 274

  Fly   280 IQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSRF-LNISLGSKFYYSGR 343
            |::|....|.|::.:||.:.:|:.||.|||:|||||:||||..|....:. |...||||:.||||
Mosquito   275 IKIRPGEFEQYESTIGFKLENHRAAKKLWKACVEHHTFFRLMTPEPQQKSGLFPRLGSKYRYSGR 339

  Fly   344 TELQA-----------------------------VQESKQR----------GRIHKVF------- 362
            |..:.                             .|:.|:|          .:.|.:.
Mosquito   340 THYETRKTPVERPAPDFKRSLTGKRLSSRSMDALAQQEKERAAAKDAGKDANKRHTMSHPPDHIP 404

  Fly   363 --------VRSP---SKRLLGAAGGVGTSGSSG--GTPMQQHSGSESANSHNNGK---------- 404
                    .|||   .|:....||||.....:|  ..|.|.....|..|. |||:
Mosquito   405 DLDSPTRGSRSPIKKDKKERKPAGGVAVLPVAGKKDKPEQVSQKDEGLNG-NNGQAEALNSSAEE 468

  Fly   405 ---PAG--AGTILTITKTSRPHDNKVTSKEADSMPRK-----------AWEQQSDEYDIQLDVGF 453
               |:|  .|.:.:..:.| |.|.|...||   .|.|           |.::...:..:|....
Mosquito   469 ATSPSGKRKGFLFSSGRKS-PKDKKDAGKE---QPAKLMAAANGDGGSAGKKDPAKEAVQARAQ- 528

  Fly   454 IEQCTRRFESASPS----PMPPAYSSGQHSPILLPTTIADAVGHQ---------------QPESG 499
             :..|.:....:|.    ..|..||..:..|         |..|:               :|...
Mosquito   529 -DTATNKTPQTTPEKPGFTKPYEYSESEQDP---------ATAHKKNVKTRGFRYDEAPLRPNEE 583

  Fly   500 SDLITIRLQADEQGR----YGFNVKGGVDLSLPVQVSK-VVPHTP-------------------A 540
            |:   .:|..:.|.|    ..||...|.|..:...|.| ..|.:|                   |
Mosquito   584 SE---AQLSPNSQSRRATGLAFNYAPGEDQKVRESVEKRKAPGSPVAATATAAGVKTDQLSPKSA 645

  Fly   541 DRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLLLEEEPLYQ 605
            .|..|...|.::.:..:.|.....:..|||                              :||
Mosquito   646 ARGLPGESEAEKGVRTSARSYSPNKGRQVV------------------------------DPL-- 678

  Fly   606 YVPESDEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKN 670
                :...|:...|.|..:.|.|.   ...|.|:.|..|            |...|.:||.....
Mosquito   679 ----ASGAGTFRPLDDTSSAFIQG---EQAGAAAAAAAA------------AAAAAAEPAKKKVK 724

  Fly   671 RYRDISPYDC---------------------------TRVSLVNSLTGDYINAN----------- 697
            ....||.:|.                           ::..|::...|..:|.|
Mosquito   725 IMVIISKFDPKTKKVDTAQGVVEHSTGVLDTKTGQIESKYGLIDPKAGTVVNFNARTGQNETFQG 789

  Fly   698 -----YVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTV 743
                 ...:.|.||.|:   :..|.:..|......:|..|.|  :|.:||:
Mosquito   790 QTDPKTGQLHIVGGVVD---SASGKVDDTLGQAIMVVPDEDS--VVEITTI 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	80/197 (41%)
		FERM_N	38..102	CDD:286467	19/63 (30%)
		FERM_M	125..232	CDD:278785	53/107 (50%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	47/93 (51%)
		FA	333..369	CDD:285894	16/92 (17%)
		PDZ_signaling	502..589	CDD:238492	19/110 (17%)
		Y_phosphatase	666..955	CDD:278528	19/121 (16%)
		PTPc	668..955	CDD:238006	19/119 (16%)
AgaP_AGAP012185	XP_320350.4	B41	37..227	CDD:214604	80/196 (41%)
		FERM_N	39..102	CDD:286467	19/63 (30%)
		FERM_M	121..227	CDD:278785	53/105 (50%)
		FERM_C_4_1_family	222..315	CDD:270005	47/92 (51%)
		FA	327..366	CDD:285894	9/38 (24%)
		4_1_CTD	<1571..1648	CDD:283537
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D29979at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920