DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and AgaP_AGAP012354

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_320202.4	Gene:	AgaP_AGAP012354 / 1280355	VectorBaseID:	AGAP012354	Length:	478	Species:	Anopheles gambiae

Alignment Length:	518	Identity:	106/518 - (20%)
Similarity:	165/518 - (31%)	Gaps:	167/518 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   487 IADAVGHQQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPRVCEGD 551
            :.|:|.:|:..       :|:...:....|.::|||.:..:|:.:||:.....||. ...:..||
Mosquito     8 VPDSVANQKRH-------VRVIKSDNNGLGISIKGGRENRMPILISKIFRGMAADN-AKGLYVGD 64

  Fly   552 EVLMINGRDVHGLRHEQVV---------------------------AMIRDCRHQASGELLLTVR 589
            .:|.:||.|:....||:.|                           ::|.:...:.....|..:.
Mosquito    65 AILSVNGEDLRDATHEEAVRALKRAGRVVDLEVKFLREVTPYFRKASIISEVGWELQRAFLCPLG 129

  Fly   590 PQRSAP-------------------LLLEEEPLYQYVPESDEIGSHSNLLDGDALFTQSLLLLSD 635
            |..|:|                   |......|..:.||:..|..||                .|
Mosquito   130 PNASSPPGVAPRSPPRADTRYIPLQLTHLARNLKYHDPENRCIELHS----------------PD 178

  Fly   636 GLASGALLA---QYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLTGDYINAN 697
            |:.|..|.|   |....:......||.::.:.|....||            :|| |:.|:..:..
Mosquito   179 GIHSCILRAMDPQEATTWFNALHSAIGKSTQKALLDANR------------ALV-SIIGELKHIG 230

  Fly   698 YVNMEIPGGA-----VNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYW-- 755
            :::....||.     .:|..|..||.:.......|:..:.||          ||..:.  ..|
Mosquito   231 WLSRRSGGGEYTHTHTHRSTAETGPNSQALAALVRLNGRSSS----------ESSDEL--DKWQS 283

  Fly   756 ---PVTGEELQLAEG--FSVRCLSEKPDE-----------------------TGSFVF------- 785
               .||..||:|.|.  :||...| :|.|                       |.|.||
Mosquito   284 IFVAVTDRELRLYESAPWSVEAWS-RPFESCPLVATRLAGAGNTSTVGSNSSTHSSVFCIRCGTT 347

  Fly   786 REFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFL---EFTER-----------VRAARNRTLLQ 836
            |..|   .|..|...:....||....|....|..:   ||:.|           |...|..|||.
Mosquito   348 RGVV---SHWLRSETNRDMAAWARVLVQGCHNAIICQREFSFRCLFQGRPCQLIVHLDRGFTLLD 409

  Fly   837 E-IEESLKQVRLMDAD---ADADENGGLMRERKCAASNGATPEDE-----TPVSTSVHQCISA 890
            . :..:.|.:.....|   ..||:...|:........:||..|.:     .||...:|.|:||
Mosquito   410 SGLGPASKALWTFPFDKLKGSADDGNKLLYLDFSGTEDGAELELDMECCPKPVVFVLHNCLSA 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894
		PDZ_signaling	502..589	CDD:238492	21/113 (19%)
		Y_phosphatase	666..955	CDD:278528	63/290 (22%)
		PTPc	668..955	CDD:238006	63/288 (22%)
AgaP_AGAP012354	XP_320202.4	PDZ_signaling	17..98	CDD:238492	19/88 (22%)
		PHsplit_syntrophin	<148..205	CDD:269960	14/72 (19%)
		PH	280..375	CDD:278594	23/98 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910