DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and AgaP_AGAP008127

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_317333.3	Gene:	AgaP_AGAP008127 / 1277829	VectorBaseID:	AGAP008127	Length:	994	Species:	Anopheles gambiae

Alignment Length:	1065	Identity:	227/1065 - (21%)
Similarity:	350/1065 - (32%)	Gaps:	359/1065 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 LLFPQKPGDVVRWVDAQKQF---------KKQCSSVSLDNDAVPLLEFRV--KFFVSDPSRLQEE 130
            :|.||.|...||:....:::         ||..:...||   :|.:|..|  :....||.....|
Mosquito    99 ILGPQSPLAFVRFTPPNEEYADEVYYPPPKKGFARQQLD---LPPVELDVLPEVVQLDPRGPSAE 160

  Fly   131 FTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEAE 195
            ..|.:.. :::|.|.||:.......|                 .:|.|           ..|:..
Mosquito   161 LERARLQ-ELQRRIALGRAMKQQQQQ-----------------QQHPP-----------DVTDYL 196

  Fly   196 RKVGELHKLHRGQL----PADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQH 256
            ....|::::...||    .|:.|.::...|.:....||...:....|.:|..|
Mosquito   197 DMGAEVNEIEDSQLLPFKAAEGERDWAYGANKRGSTGIFRDQQAGGNDEERAL------------ 249

  Fly   257 SLRVNTFSWSKMVKVSFKRKDFFIQLRREPSE---NYDTLLGFGMSSHKHAKALWKSCVEHH--- 315
                               ||...:|  .|::   .::.:.....|..::||       |||
Mosquito   250 -------------------KDLVDRL--TPADVDPEFEYIYPKTSSFREYAK-------EHHIPK 286

  Fly   316 -SFFRLKRPHRLSRFLNISLGS---------KFYYSGRTEL--QAVQESKQRGRIHKVFVRSPSK 368
             |.|   .|..::|....:.|:         |||......|  .|..|....|.:.:....:|..
Mosquito   287 ISNF---APENVNRLQQEAAGAAKANDPNVDKFYTHPHKALAQHARNEIPAAGNLRESAAYAPGP 348

  Fly   369 RLLGAAGGVGTSG------SSGGTPMQQHSGSESANSHNNGKPAGAGTILTITKTSR-------P 420
            .    |||:.|.|      .|||:|     |.:.|.:.       ...||..|:..|       |
Mosquito   349 E----AGGMYTEGGFVYVPKSGGSP-----GKDEARTL-------LDNILGFTRRERLDVKKPGP 397

  Fly   421 HDNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPP----AYSSGQHSPI 481
            ......|.::.|.|.|......|:              ...|.....|...    |::...|:|.
Mosquito   398 PAAPPPSSQSPSEPPKETAPSQDK--------------AHGEEGEKRPKSKKELFAHTDDDHAPH 448

  Fly   482 LLPTTIADAVGHQQP----ESGSDLITIRLQ-ADEQGRY----------GFNVKGGVDLSLPVQV 531
            .:.|..|..: .:.|    :.||.::....: .:.||.:          .|.|:...|......|
Mosquito   449 SVDTEYAHVI-LKNPIDNWKDGSRIVAALAELLNMQGYFTHPRVDRHEVSFRVEANPDRKTAADV 512

  Fly   532 SK------------------VVPHTPADRC---------TPRVCEGDEV-----LMINGRDVHGL 564
            :|                  |:.....|:.         ..||.:|..|     .|..|.   |.
Mosquito   513 AKQINDSRFKNNLSRRLGVLVIQAGVGDKTKETDVSSQRLKRVEDGPNVTHVMAYMFAGA---GA 574

  Fly   565 RHEQVVAM----IRD----------------------------CRHQASGE-------------- 583
            ....||||    ||.                            ||.:.:|.
Mosquito   575 AAVIVVAMTLFLIRKHDKKKDKLGGLQSGLGGGDSSSKDYQDLCRARMAGGKTGPAGSDSPGGRI 639

  Fly   584 LLLT----VRP--QRSAPLLLEEEPLYQYVPESDEIGSHSNLLDGDALFTQSLLLLSDGLAS-GA 641
            ..||    .||  .||:.....|||..          ::.::..|..:    |..:.|.|.: |.
Mosquito   640 TALTKEAEARPPSSRSSTSSWSEEPAL----------TNMDISTGHMV----LSYMEDHLRNKGR 690

  Fly   642 LLAQYELMYRKNPDLAITEARKPAN-APKNRYRDISPYDCTRV---SLVNSLTGDYINANYVNME 702
            |..::|.:.|...:.:..:|...|. ||.||.....|||.:||   .|.|:...|||||:.:...
Mosquito   691 LQREWEALCRYEAEPSARDAALQAQCAPLNRPGAPLPYDHSRVVLNHLANAEGMDYINASTITDH 755

  Fly   703 IPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEG 767
            .|....  |:|.|||:.||...||:||.::.:.:||.|..:.|:|...|.:|||..|.|:.  ..
Mosquito   756 DPRAPA--YVAAQGPMQSTLAHFWQMVWEQGAVVLVALCRLQENGESACARYWPEEGAEVY--HI 816

  Fly   768 FSVRCLSEK--PDETGSFVFREFVLKDKH--EQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRA 828
            :.|..:||.  .|:   ::.|.|.||:..  |.|.:....:|:||...||:.....|:|..:|..
Mosquito   817 YEVHLVSEHIWCDD---YLVRSFYLKNLRTGETRTVTQFHFLSWPQGGVPTSAKALLDFRRKVNK 878

  Fly   829 ARNRTLLQEIEESLKQVRLMDADADADENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANP 893
            :                               .|.|.|
Mosquito   879 S-------------------------------YRGRSC--------------------------- 885

  Fly   894 PVIVHCSAGIGRTGVLILMDTALALME--AREPVYPLDIVRT---MRDQRACMVQNVSQYRF--- 950
            |::||.|.|.||||..||:|..|..|.  |||    :||..|   :|||||.:|....|:.|
Mosquito   886 PIVVHSSNGSGRTGAYILLDLVLGRMNKGARE----IDIAATLEHLRDQRAGLVATRQQFEFVLM 946

  Fly   951 -VCECICAAYMKISRSSAAINDDED 974
             |.|.:.|....:.:|::.....:|
Mosquito   947 AVAEEVHAILKALPQSTSGSKGSQD 971

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	33/169 (20%)
		FERM_N	38..102	CDD:286467	8/33 (24%)
		FERM_M	125..232	CDD:278785	18/110 (16%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	17/100 (17%)
		FA	333..369	CDD:285894	9/46 (20%)
		PDZ_signaling	502..589	CDD:238492	27/179 (15%)
		Y_phosphatase	666..955	CDD:278528	90/305 (30%)
		PTPc	668..955	CDD:238006	89/302 (29%)
AgaP_AGAP008127	XP_317333.3	Receptor_IA-2	455..541	CDD:288410	12/86 (14%)
		PTPc	691..950	CDD:214550	94/327 (29%)
		PTPc	726..950	CDD:238006	85/292 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910