DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and Patj

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_766284.2	Gene:	Patj / 12695	MGIID:	1277960	Length:	1834	Species:	Mus musculus

Alignment Length:	956	Identity:	175/956 - (18%)
Similarity:	326/956 - (34%)	Gaps:	270/956 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 WVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDP---------SRLQEEFTRYQFYLQIKRNI 144
            ::|..|..:.|...|...::|..:.|     |:|.|         ..:.||:..||.:|:...:
Mouse   830 FLDLGKSLQFQQKDVDSSSEAWEMHE-----FLSPPLDGRGEEREMLVDEEYELYQDHLRAMES- 888

  Fly   145 LLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEAERKVGELHKLHRGQL 209
               ..|.....:...||..::.:.|                   .|...|....||..:.|..:.
Mouse   889 ---NPPPPHIREAAPASPVLELQAG-------------------TQWLHANLSGGERLECHDAES 931

  Fly   210 PADA------EYNYLEHAKRLELYGIDLHR---ATDSNGKELQLGVSAVGLLVFQHSLRVNTFSW 265
            ...|      :|:|.......|.:|:|...   :::.||:..:.  ..:|.|   |||..::...
Mouse   932 MMSAYPQEMQQYSYSTADMMEETFGLDSRAPIPSSEGNGQHGRF--DDMGHL---HSLTSSSLDL 991

  Fly   266 SKMV--------------KVSFKRKDFFIQLRREPSENYDTLLG--FGMSSHKHAKALWKSC--- 311
            ..|:              .|:.:|:...:.|.|.||....|...  .|:.|.:||.|   :|
Mouse   992 GMMIPSDLQGPGVLVDLPAVAQRREQEDLPLYRLPSARVVTKPSSHMGLVSSRHANA---ACELP 1053

  Fly   312 ---------VEHHSFFRLKRPHRLSRFLNISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPS 367
                     ..:.|.:...|...:.|..|:|||... ..|:|.::.::..::   :..:|:
Mouse  1054 EREEGEGEETPNFSHWGPPRIVEIFREPNVSLGISI-VGGQTVIKRLKNGEE---LKGIFI---- 1110

  Fly   368 KRLLGAAGGVGTSGSSGGTPMQQHSGSESAN-SHNNG----KPAGAGTILTITKTSRPHDNKVTS 427
            |::|..:....|:....|..:.:.||.:..| ||...    |.||...:..:...|.......|.
Mouse  1111 KQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHAEAVEAIKSAGNPVVFVVQSLSSTPRVIPTV 1175

  Fly   428 KEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSGQHSPILLPTTIADAVG 492
            ......|....:|.:.|          .:..|...:..|..:||.|.:        |:  ||..|
Mouse  1176 NNKGKTPAPNQDQNTQE----------RKAKRHGTAPPPMKLPPPYRA--------PS--ADMEG 1220

  Fly   493 HQQ-------------PESGSDLITIRLQADEQGRYGFNVKGGVDLS-LPVQVSKVVPHTPADRC 543
            .::             .:...:|..|.|:.|:.| .|.::.|..|.| :.:.|..:.|..|| ..
Mouse  1221 SEEDCALTDKKIRQRYADLPGELHIIELEKDKNG-LGLSLAGNKDRSRMSIFVVGINPEGPA-AA 1283

  Fly   544 TPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDC----------RHQASGELLLTVRPQRS-APLL 597
            ..|:..|||:|.||.:.::|..|:...|:|:..          ...|..::.:...|:.| :|..
Mouse  1284 DGRMRIGDELLEINNQILYGRSHQNASAIIKTAPTRVKLVFIRNEDAVSQMAVAPFPELSHSPSP 1348

  Fly   598 LEE---------------EPLYQYVPESDEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYE 647
            :|:               :..:...|||.:....|.::|.:.:..|                |.|
Mouse  1349 VEDLGGTELVSSEEESSVDAKHLPEPESSKPEDLSQVVDDNMVAEQ----------------QKE 1397

  Fly   648 LMYRKNPDLAITEARK-----------------PANAPKNRYRDIS---------PYDCTRVSLV 686
               .::||.|..:.::                 ||...::.:.|::         |.|...:| |
Mouse  1398 ---SESPDSAACQIKQQTYSTQVSSSSQDSPSSPAPLCQSAHADVTGSGNFQAPLPVDPAPLS-V 1458

  Fly   687 NSLTGDYINANYVNMEIPGGAVNRYIATQG----PLASTTTDFWRMVQQESSHLLVMLTTVMESG 747
            :..|...:....:.:||..|.....::..|    ||.:                 :::..|.|.|
Mouse  1459 DPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLDA-----------------IVIHEVYEEG 1506

  Fly   748 -RQKCHQYWPVTGEELQLAEGFSVR---------CLSEKPDETGSFVFREFVLKDKHEQRHIHHM 802
             ..:..:.|  .|:::....|..:|         .|.:.|.:....|:|     |:.:.|...::
Mouse  1507 AAARDGRLW--AGDQILEVNGVDLRSSSHEEAITALRQTPQKVRLVVYR-----DEAQYRDEENL 1564

  Fly   803 QYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMD--ADADADENGGLMRERK 865
            :              :||...:: :..|...|....:.|...|.:.|  ....||.:|.|:|..:
Mouse  1565 E--------------VFLVDLQK-KTGRGLGLSIVGKRSGSGVFISDIVKGGAADLDGRLIRGDQ 1614

  Fly   866 CAASNGATPEDETPVS----TSVHQCISAANPPVIVHCSAGIGRTG 907
            ..:.||   ||....|    .::.:|:..     :|....|..|.|
Mouse  1615 ILSVNG---EDMRHASQETVATILKCVQG-----LVQLEIGRLRAG 1652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	29/157 (18%)
		FERM_N	38..102	CDD:286467	3/12 (25%)
		FERM_M	125..232	CDD:278785	20/112 (18%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	24/124 (19%)
		FA	333..369	CDD:285894	6/35 (17%)
		PDZ_signaling	502..589	CDD:238492	25/97 (26%)
		Y_phosphatase	666..955	CDD:278528	47/271 (17%)
		PTPc	668..955	CDD:238006	47/269 (17%)
Patj	NP_766284.2	L27_2	8..65	CDD:312549
		PDZ_signaling	135..218	CDD:238492
		PDZ_signaling	248..325	CDD:238492
		PDZ_signaling	363..450	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	456..488
		PDZ_signaling	572..636	CDD:238492
		PDZ	685..774	CDD:214570
		PDZ_signaling	1072..1163	CDD:238492	21/98 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1171..1219		12/67 (18%)
		PDZ	1242..1327	CDD:214570	24/86 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1340..1453		19/131 (15%)
		MPDZ_u10	<1453..1468	CDD:374710	3/15 (20%)
		PDZ	1469..1554	CDD:214570	17/108 (16%)
		PDZ_signaling	1566..1646	CDD:238492	19/88 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1657..1676
		PDZ_signaling	1707..1792	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1811..1834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910