DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptpmeg and FRMD6

DIOPT Version :9

Sequence 1:NP_001163309.2 Gene:Ptpmeg / 38059 FlyBaseID:FBgn0261985 Length:974 Species:Drosophila melanogaster
Sequence 2:NP_001253975.1 Gene:FRMD6 / 122786 HGNCID:19839 Length:622 Species:Homo sapiens


Alignment Length:654 Identity:132/654 - (20%)
Similarity:241/654 - (36%) Gaps:153/654 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 DKKTPQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWV 90
            :.:..|.::.|.:...:|.:....|..:....:||.||...|.|.:...|||...|....|...:
Human     8 NNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMEL 72

  Fly    91 DAQ------KQFKKQCSSV-------SLDNDAVP-LLEFRVKFFVSDPSRLQEEFTRYQFYLQIK 141
            ..:      |::||:.|.|       .:|....| ::.|||:::|.:...:.:...||.:|..::
Human    73 SQKLYKYCPKEWKKEASKVRQYEVTWGIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLR 137

  Fly   142 RNILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEAERK------VGE 200
            :.:|..:.........|||::.:|::||:|...:|...|................|      :..
Human   138 KQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIPN 202

  Fly   201 LHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGK---ELQLGVSAVGLLVFQH----SL 258
            :||.......::|...|::.|.||:...:..:|......:   .|.||::..|:.:||:    ..
Human   203 MHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQNLDEEKQ 267

  Fly   259 RVNTFSWSKMVKVSFKRKDFFIQLRREPSEN---YDTLLGFGMSSHKHAKALWKSCVEHHSFFRL 320
            .:..|.|:.:.|:.|..|.|.|.....||..   |.|  |..|.|             .|....|
Human   268 LLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYT--GCPMRS-------------RHLLQLL 317

  Fly   321 KRPHRLSRFLNISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSP--------SKRLLGAAGGV 377
            ...|||  ::|:....:       .::.::|::::.:..:.::...        .||       .
Human   318 SNSHRL--YMNLQPVLR-------HIRKLEENEEKKQYRESYISDNLDLDMDQLEKR-------S 366

  Fly   378 GTSGSSGGT----PMQQHSGSESANSHNNG-----KPAGAG---------------TILTITKTS 418
            ..||||.|:    .:.:||.:..::||.:|     ||...|               |..::|...
Human   367 RASGSSAGSMKHKRLSRHSTASHSSSHTSGIEADTKPRDTGPEDSYSSSAIHRKLKTCSSMTSHG 431

  Fly   419 RPHDNKVTSKEADSMPRKAWEQQSDEYDIQL-DVGFIEQCTRRFESASPSP---------MPPAY 473
            ..|.:.|.|...|.:..   :.|.||.::.: |...:||...  ||...||         |..:.
Human   432 SSHTSGVESGGKDRLEE---DLQDDEIEMLVDDPRDLEQMNE--ESLEVSPDMCIYITEDMLMSR 491

  Fly   474 SSGQHSPILLPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHT 538
            ....||.:     |...:|.....|...::.:|.|:.:              |||..:.: .|.|
Human   492 KLNGHSGL-----IVKEIGSSTSSSSETVVKLRGQSTD--------------SLPQTICR-KPKT 536

  Fly   539 PADRCTPRVCEGDEVLMINGRD---VHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLLLEE 600
            ..||.:..:   |::.:.. :|   :.||..:...:....|.|:                  |:|
Human   537 STDRHSLSL---DDIRLYQ-KDFLRIAGLCQDTAQSYTFGCGHE------------------LDE 579

  Fly   601 EPLY 604
            |.||
Human   580 EGLY 583

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PtpmegNP_001163309.2 B41 35..232 CDD:214604 46/216 (21%)
FERM_N 38..102 CDD:286467 16/69 (23%)
FERM_M 125..232 CDD:278785 21/112 (19%)
FERM_C_PTPN4_PTPN3_like 226..320 CDD:270010 22/103 (21%)
FA 333..369 CDD:285894 1/43 (2%)
PDZ_signaling 502..589 CDD:238492 15/89 (17%)
Y_phosphatase 666..955 CDD:278528
PTPc 668..955 CDD:238006
FRMD6NP_001253975.1 FERM_F1_FRMD6 15..120 CDD:340718 25/104 (24%)
FERM_B-lobe 128..226 CDD:271216 19/97 (20%)
FERM_C_FRMD1_FRMD6 227..335 CDD:270006 27/131 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 364..445 20/87 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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