DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and Ptprn

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_017451718.1	Gene:	Ptprn / 116660	RGDID:	620777	Length:	1064	Species:	Rattus norvegicus

Alignment Length:	929	Identity:	192/929 - (20%)
Similarity:	290/929 - (31%)	Gaps:	374/929 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 LRREPSENYDTLLGFGMSSHKHAKALWKSCVEH--------HSFFRLKRPHRLSRFLNISLGSKF 338
            |.|.|.:.....:|..:||.:  ..|....:||        |.....: |..|..:|....||:.
  Rat   242 LSRPPGDGNGAGVGSPLSSLQ--AELLPPLLEHLLMPPQPPHPSLTYE-PALLQPYLFQQFGSRD 303

  Fly   339 YYSGRTELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQ-------------- 389
            ...|......|.....:.....:|.||.||.:||...|......:|.:|.|
  Rat   304 GSRGSESASGVVGHLAKAEDPVLFSRSLSKAILGTHSGHSFGDLTGPSPAQLFQDSGLLYMAQEL 368

  Fly   390 ------------QHSGSESANSHNNGKPAGAGTILTITKTSRPHDNKVTSKEADSMPRKAWEQQS 442
                        :..||..|...:.|                 |:.:|.....:..|.:| .|.:
  Rat   369 PVPGRARAPRLPEEGGSSRAEDSSEG-----------------HEEEVLGGHGEKSPPQA-VQAA 415

  Fly   443 D-----------EYDIQL----------------------------------DV-GFIEQCTRRF 461
            |           .|.::|                                  || ..||:..:|.
  Rat   416 DVSLQRLAAVLAGYGVELRQLTPEQLSTLLTLLQLLPKGTGRHLGGAVNGGADVKKTIEEQMQRG 480

  Fly   462 ESAS---PSPMPPAYSSGQHSPILLPTTIADAVGHQQPESGSDLITI------------------ 505
            ::|.   |:|:.|.:.:...:.|.:...::.  |..:|...|..:.|
  Rat   481 DTADARPPTPLLPGHPTASSTSIKVRQVLSP--GFPEPPKTSSPLGISAVLLEKKSPLGQSQPTV 543

  Fly   506 ------RLQADEQGRYGFNVKGGVDLSLP--------------------VQVSKVVPHTPADRCT 544
                  |..|:|   ||:.|.....|||.                    :.:|.|.|     ..|
  Rat   544 VGQPSARPSAEE---YGYIVTDQKPLSLVAGVKLLEILAEHVHMTSGSFINISVVGP-----AVT 600

  Fly   545 PRVCEGDEVLMINGRDVH-----------------------GLRHEQVVAMIRDCRHQASGELLL 586
            .|:...::.|.:  .||.                       |.|.|....:.|    ||.|
  Rat   601 FRIRHNEQNLSL--ADVTQQAGLVKSELEAQTGLQILQTGVGQREESAAVLPR----QAHG---- 655

  Fly   587 TVRPQRSAPLLL--------------------------EEEPLYQYVPESDEIGSHSNLLDGDAL 625
             :.|.||..|.|                          ::|.|....||    |:|     ||..
  Rat   656 -ISPMRSLLLTLVALAGVAGLLVALAVALCMRHHSKQRDKERLAALGPE----GAH-----GDTT 710

  Fly   626 F-----------TQSLLLLSDG-----------------------------------------LA 638
            |           |:||...::|                                         ::
  Rat   711 FEYQDLCRQHMATKSLFNRAEGQPEPSRVSSVSSQFSDAAQASPSSHSSTPSWCEEPAQANMDIS 775

  Fly   639 SGALLAQYELMYRKNPDLAITE----------------ARKPANAPKNRYRDISPYDCTRVSL-V 686
            :|.::..|...:.:|.|....|                |:...|..|||:.|..|||..|:.| |
  Rat   776 TGHMILAYMEDHLRNRDRLAKEWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKV 840

  Fly   687 NS--LTGDYINANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQ 749
            .|  ...|||||:.:....|  .:..||||||||:.|..|||:||.:....::||||.::|.|.:
  Rat   841 ESSPSRSDYINASPIIEHDP--RMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVK 903

  Fly   750 KCHQYWPVTGEELQLAEGFSVRCLSEK---PDETGSFVFREFVLKD--KHEQRHIHHMQYLAWPD 809
            :|.:|||..|..|.  ..:.|..:||.   .|    |:.|.|.||:  ..|.|.:....:|:||.
  Rat   904 QCDRYWPDEGSSLY--HVYEVNLVSEHIWCED----FLVRSFYLKNVQTQETRTLTQFHFLSWPA 962

  Fly   810 HCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGLMRERKCAASNGATP 874
            ...|:.....|:|..:
  Rat   963 EGTPASTRPLLDFRRK------------------------------------------------- 978

  Fly   875 EDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTM---RD 936
                     |::|....:.|:|||||.|.||||..||:|..|..|  .:.|..:||..|:   ||
  Rat   979 ---------VNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRM--AKGVKEIDIAATLEHVRD 1032

  Fly   937 QRACMVQNVSQYRFVCECI 955
            ||..:|::..|:.|....:
  Rat  1033 QRPGLVRSKDQFEFALTAV 1051

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	10/45 (22%)
		FA	333..369	CDD:285894	8/35 (23%)
		PDZ_signaling	502..589	CDD:238492	25/153 (16%)
		Y_phosphatase	666..955	CDD:278528	90/299 (30%)
		PTPc	668..955	CDD:238006	89/297 (30%)
Ptprn	XP_017451718.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910