DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and PTPRT

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_024307588.1	Gene:	PTPRT / 11122	HGNCID:	9682	Length:	1535	Species:	Homo sapiens

Alignment Length:	1013	Identity:	229/1013 - (22%)
Similarity:	364/1013 - (35%)	Gaps:	309/1013 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 RWVDAQKQFKK----QCSSVSLDNDAVPLLEFRVKFFVSDP-SRLQEEFTRYQFYLQIKRNILLG 147
            ::|..|:|::.    |.||........|.:..|::..:|:| .|::.|    :..:|.:.:: .|
Human   427 QYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESE----ELVVQTEEDV-PG 486

  Fly   148 KLPCSS------------------NTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEA 194
            .:|..|                  .|..::..|.:     ::.|:    |.|.....|..|..:.
Human   487 AVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEI-----NYKAV----GSLDPSADLSSQRGKV 542

  Fly   195 ERKVGELHKLHRGQLPADAEYNYLEHAKRLELYG--IDLHRATDSNGKELQLGVSAVGLLVFQHS 257
            .:...|.|.|..|..|. ..|::...|...:.:|  :....||.         :||..:..:...
Human   543 FKLRNETHHLFVGLYPG-TTYSFTIKASTAKGFGPPVTTRIATK---------ISAPSMPEYDTD 597

  Fly   258 LRVN--TFSWSKMVKVSFKR-----------KDFFIQLRREPSENYDTLLGFGMS-SHKHAKALW 308
            ..:|  ..:.:.|:|.:..|           |:..:|..|..:   |.:..|.:. |:::|.:|
Human   598 TPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAA---DIIECFSVPVSYRNASSL- 658

  Fly   309 KSCVEHHSFFRLKRPHRLSRFLNISLGSKFYYSG------------RTELQAVQESKQRGRIHKV 361
               ...|.|....:|..|......::|....|:|            ....||:  ||..|.....
Human   659 ---DSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQAL--SKANGETKIN 718

  Fly   362 FVRSPSKRLLGAAGGVGTSGSSGGTPM-QQHSGSESANSH---------NNGKPAGA-------- 408
            .||..:|..:|:|      ..:.|||: ...:|:.:.||:         |..|.||.
Human   719 CVRLATKAPMGSA------QVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFI 777

  Fly   409 ----GTILTITKTSRPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPM 469
                |.:|||.:.                 |.|:   |..|.::|     .:..:..:|.:...|
Human   778 IILLGVMLTIKRR-----------------RNAY---SYSYYLKL-----AKKQKETQSGAQREM 817

  Fly   470 PPAYSSGQHSPILLPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKV 534
            .|..|:.:      |||...|..:.:..|.|          .|...||......:||.|....:.
Human   818 GPVASADK------PTTKLSASRNDEGFSSS----------SQDVNGFTDGSRGELSQPTLTIQT 866

  Fly   535 VPHTPADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTV-RPQRSAPLLL 598
            .|:        |.|  |.|.|...||       |....||      ..:||..: :.:|......
Human   867 HPY--------RTC--DPVEMSYPRD-------QFQPAIR------VADLLQHITQMKRGQGYGF 908

  Fly   599 EEEPLYQYVPESDEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARK 663
            :||  |:.:||.......:...|.:....:...::|....|.|..|.    .||.|.|....:..
Human   909 KEE--YEALPEGQTASWDTAKEDENRNKNRYGNIISCRGRSPAKRAD----MRKTPQLDKEMSSV 967

  Fly   664 PANAPKNRYRDISPY--DCTRVSLVNSLTG----DYINANYVN-MEIPGGAVNRYIATQGPLAST 721
            ...||..:.|.::..  |.:||.|: .|.|    |||||||:: ...|    ..|||||||:..|
Human   968 FPEAPLIQRRTLAATWDDHSRVRLL-VLDGDPHSDYINANYIDGYHRP----RHYIATQGPMQET 1027

  Fly   722 TTDFWRMVQQESSHLLVMLTTVMESGRQ--------------------KCHQYWPVTGEELQLAE 766
            ..|||||:.||:|..:||:|.::|.||.                    ||.:|||   ::.::..
Human  1028 VKDFWRMIWQENSASIVMVTNLVEVGRHPAEHTVGNATLGRAASPGMVKCVRYWP---DDTEVYG 1089

  Fly   767 GFSVRCLSEKPDETGSFVFREFVLKDK--HEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAA 829
            ...|..:..:|  ...:|.|.|.::.|  ||.|.:....:.:||||.||......|.|
Human  1090 DIKVTLIETEP--LAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGF------- 1145

  Fly   830 RNRTLLQEIEESLKQVRLMDADADADENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANP- 893
                        ::||:.:                                           ||
Human  1146 ------------VRQVKFL-------------------------------------------NPP 1155

  Fly   894 ---PVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCE-- 953
               |::||||||.||||..|.:||.|.:.|....|...:.||.:|.||..:||...||.||.:
Human  1156 EAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI 1220

  Fly   954 ---CIC-----------AAYMKISR-----SSAAINDD 972
               |:|           :.|..|||     :|:.|.|:
Human  1221 LEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDE 1258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	31/168 (18%)
		FERM_N	38..102	CDD:286467	4/17 (24%)
		FERM_M	125..232	CDD:278785	21/126 (17%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	19/109 (17%)
		FA	333..369	CDD:285894	10/47 (21%)
		PDZ_signaling	502..589	CDD:238492	19/87 (22%)
		Y_phosphatase	666..955	CDD:278528	93/326 (29%)
		PTPc	668..955	CDD:238006	92/324 (28%)
PTPRT	XP_024307588.1	MAM	29..189	CDD:214533
		fn3	294..360	CDD:306538
		FN3	390..480	CDD:238020	12/56 (21%)
		fn3	502..577	CDD:306538	15/84 (18%)
		PTPc	985..1222	CDD:238006	90/308 (29%)
		PTPc	1284..1504	CDD:238006
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910