DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptpmeg and PTPN21

DIOPT Version :9

Sequence 1:NP_001163309.2 Gene:Ptpmeg / 38059 FlyBaseID:FBgn0261985 Length:974 Species:Drosophila melanogaster
Sequence 2:NP_008970.2 Gene:PTPN21 / 11099 HGNCID:9651 Length:1174 Species:Homo sapiens


Alignment Length:1268 Identity:300/1268 - (23%)
Similarity:459/1268 - (36%) Gaps:424/1268 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 GPELARDKK-TPQRQQCVT--VLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQ 81
            |.:|.|.:: |...:.|:.  :..|::....|.:...:.|.|.|:.|.|.|||.|..||.|.:..
Human     6 GLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYN 70

  Fly    82 KPGDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILL 146
            |... .||||.:|..|||....:|:    |.:.|.|.|:|...|:||:|.||||:|||:|::||.
Human    71 KQNQ-RRWVDLEKPLKKQLDKYALE----PTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILE 130

  Fly   147 GKLPCSSNTQCLLASYTVQSELGDFNALEHQP----------GYLSGMQLLCDQTTEAERKVGEL 201
            |.:||:......||...||::.|||:..|.|.          |:|...::|    .||.:||..|
Human   131 GSIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKVL----EEATQKVALL 191

  Fly   202 HKLHRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLV-FQHSLRVNTFSW 265
            |:.:||....|||..|::..:|::.||.:.:.|.||.|.::.:|....|:.| .::......|.|
Human   192 HQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRW 256

  Fly   266 SKMVKVSFKRKDFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKR-------- 322
            ..:..:|..:..|.::|     .|.:..:.|.....:.||.:|:.||..|.|:||.:        
Human   257 HDIANMSHNKSFFALEL-----ANKEETIQFQTEDMETAKYIWRLCVARHKFYRLNQCNLQTQTV 316

  Fly   323 ---PHRLSRFLNISLGS----------KFYYSGR-TELQAVQESKQRGRIHKVFVRSP------S 367
               |.|......:||..          :.:|:|. ||..|..:.       .:||.:.      |
Human   317 TVNPIRRRSSSRMSLPKPQPYVMPPPPQLHYNGHYTEPYASSQD-------NLFVPNQNGYYCHS 374

  Fly   368 KRLLGAAGGVGTSGS-SGGTPMQQHSGSESANSHNNGK------PAGAGTILTITKTSRP----- 420
            :..|..| .:..:|. ..|:....|    |.||.||.:      |..:...:|.:...||     
Human   375 QTSLDRA-QIDLNGRIRNGSVYSAH----STNSLNNPQPYLQPSPMSSNPSITGSDVMRPDYLPS 434

  Fly   421 -----------------------------HDNK---------VTSKEADSMPRK-AWEQQSDEYD 446
                                         |..:         :.|..|.|.|.. .:.|......
Human   435 HRHSAVIPPSYRPTPDYETVMKQLNRGLVHAERQSHSLRNLNIGSSYAYSRPAALVYSQPEIREH 499

  Fly   447 IQLDVGFIEQC----TRRFESASPSPMP------------PAYSSGQ------HSPILLPTTI-- 487
            .||.......|    :..|.|.||.|.|            |..::.|      .||.::.|.:  
Human   500 AQLPSPAAAHCPFSLSYSFHSPSPYPYPAERRPVVGAVSVPELTNAQLQAQDYPSPNIMRTQVYR 564

  Fly   488 --------------ADAVGHQQ-PESGSDLITIRLQADEQ------------------------- 512
                          .|...|.. ..|..||||.|:....|                         
Human   565 PPPPYPPPRPANSTPDLSRHLYISSSNPDLITRRVHHSVQTFQEDSLPVAHSLQEVSEPLTAARH 629

  Fly   513 ----------------GRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPRVC------EGDEVLM 555
                            |..|..:|   :.:|....::|.|...:....|.|.      ||.|   
Human   630 AQLHKRNSIEVAGLSHGLEGLRLK---ERTLSASAAEVAPRAVSVGSQPSVFTERTQREGPE--- 688

  Fly   556 INGRDVHGLRH------EQVVAMIRDCR-------HQASGELLLTVRPQRSAPLLLEEE------ 601
                :..|||:      .....:|....       .:.||......|.:...|.|.::.      
Human   689 ----EAEGLRYGHKKSLSDATMLIHSSEEEEDEDFEEESGARAPPARAREPRPGLAQDPPGCPRV 749

  Fly   602 ----PLY-----QYVPE------------------------------------------------ 609
                ||:     .:||:                                                
Human   750 LLAGPLHILEPKAHVPDAEKRMMDSSPVRTTAEAQRPWRDGLLMPSMSESDLTTSGRYRARRDSL 814

  Fly   610 -----SDEIGSHSNLLDG----------------------DALFTQSL----------------- 630
                 ||.:....|:::|                      .||...||                 
Human   815 KKRPVSDLLSGKKNIVEGLPPLGGMKKTRVDAKKIGPLKLAALNGLSLSRVPLPDEGKEVATRAT 879

  Fly   631 -----LLLSDGLASGALLAQYELMYRKN-PDLAITEARKPANAPKNRYRDISPYDCTRVSLV--- 686
                 .:|...|..|.:..:||.:.:|. .|...:.||.|.||.:||::|:.|||..||.||   
Human   880 NDERCKILEQRLEQGMVFTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTK 944

  Fly   687 NSLTGDYINANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKC 751
            .:.|| ||||:::.:.:.|...: ||||||||.:|..|||:||.::...::.|:|...|.||:|.
Human   945 ENNTG-YINASHIKVSVSGIEWD-YIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKS 1007

  Fly   752 HQYWP--------VTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLKDKH----EQRHIHHMQY 804
            .:|||        ||....::...|          .|.|..:....||.||    ::|.:.|:||
Human  1008 FRYWPRLGSRHNTVTYGRFKITTRF----------RTDSGCYATTGLKMKHLLTGQERTVWHLQY 1062

  Fly   805 LAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGLMRERKCAAS 869
            ..||:|..|.|...||.:.|.:::.|..|                                    
Human  1063 TDWPEHGCPEDLKGFLSYLEEIQSVRRHT------------------------------------ 1091

  Fly   870 NGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRT- 933
             .:|.:.::|            |||::||||||:|||||:||.:..:|.:|..|   .|||.|. 
Human  1092 -NSTSDPQSP------------NPPLLVHCSAGVGRTGVVILSEIMIACLEHNE---VLDIPRVL 1140

  Fly   934 --MRDQRACMVQNVSQYRFVCECICAAYMKISR 964
              :|.||..:||.:.||.||.. :...::|.||
Human  1141 DMLRQQRMMLVQTLCQYTFVYR-VLIQFLKSSR 1172

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PtpmegNP_001163309.2 B41 35..232 CDD:214604 74/208 (36%)
FERM_N 38..102 CDD:286467 23/63 (37%)
FERM_M 125..232 CDD:278785 44/116 (38%)
FERM_C_PTPN4_PTPN3_like 226..320 CDD:270010 23/94 (24%)
FA 333..369 CDD:285894 10/52 (19%)
PDZ_signaling 502..589 CDD:238492 22/146 (15%)
Y_phosphatase 666..955 CDD:278528 99/306 (32%)
PTPc 668..955 CDD:238006 97/304 (32%)
PTPN21NP_008970.2 B41 24..222 CDD:214604 73/206 (35%)
FERM_N 27..90 CDD:286467 23/63 (37%)
FERM_M 109..220 CDD:278785 44/114 (39%)
FERM_C_PTPN14_PTPN21 217..307 CDD:270009 24/94 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 396..445 10/52 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..692 5/25 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 711..745 5/33 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 769..806 0/36 (0%)
PTPc 896..1166 CDD:214550 106/334 (32%)
PTPc 923..1166 CDD:238006 97/307 (32%)
Substrate binding. /evidence=ECO:0000250 1108..1114 4/5 (80%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0792
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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