Protein Alignment Ptpmeg and Ect2l

DIOPT Version :9

• Sequence 1: NP_001163309.2
• Gene: Ptpmeg / 38059
• FlyBaseID: FBgn0261985
• Length: 974
• Species: Drosophila melanogaster
• Sequence 2: XP_038949113.1
• Gene: Ect2l / 103689991
• RGDID: 9246970
• Length: 986
• Species: Rattus norvegicus
• Alignment Length: 1053
• Identity: 197/1053 - (18%)
• Similarity: 346/1053 - (32%)
• Gaps: 343/1053 - (32%)

  Fly    23 LARDKKTPQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQ-----VFQYLE-------------- 68
            |:|..|:..|       |:.|.....:...|...|.:|.:     :|.:|.
  Rat    63 LSRSSKSQLR-------FIQDWLSERKQVARVDFSTVLPRCISLYIFSFLNPKDLCAAAQVSWPW 120

  Fly    69 --LSERD--------YFGLLFPQKP--GDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFV 121
              |:|:|        .||...|..|  .:...|    ||....|.| ||| ...|.....|...:
  Rat   121 KFLTEQDCLWMPKCTRFGWFLPYAPTRNEYGAW----KQHYIACVS-SLD-WLTPREAAAVYGTL 179

  Fly   122 SDP--------SRLQEEFTRYQFYLQI---KRNILLGKLPCSSNTQCLLASYTVQSELGDFNALE 175
            ::|        .|.:|:..|...:.:|   |:.:...:.|..:.|:|   |.:::        ..
  Rat   180 NEPKTEDEELQERQREKCLRKTIWEKIALRKKELFKARPPWLTGTRC---SRSLK--------CT 233

  Fly   176 HQPGYLSGMQLLCDQTTEAERKVGELHKLHRGQLP----ADAEYNYLEHAKRLELYGIDLHRATD 236
            ..||   |.||..|:|...|....:..:.....||    ....::||...|:..   .:|.|..|
  Rat   234 SLPG---GPQLWRDRTGFCEALERQFLRASLDALPQRSNISGSHSYLSLLKKSH---PELGRTDD 292

  Fly   237 SN----------------GKELQLGVSAVGLLVFQ---HSLRVNTFSWSKMVKVSFKRKDFFIQL 282
            |:                ..|:.||..|..|.|||   .:|...|:.|..:       |...:.:
  Rat   293 SSSCESPLHVILISSRIPAYEVPLGEGATPLTVFQLHGQNLLAATWCWIGV-------KAGVVAV 350

  Fly   283 RREP-SENYDTLL-------------GFGMSSHKHAKAL-----WKSCVEHHSFFRLKRPHRLSR 328
            ..|| ...::.||             |.|:.|..:::.:     :|.|:::     |..| .:..
  Rat   351 LYEPRGVTFEGLLHLLGRAQQGRKAQGLGIFSSGNSREIDLLQGYKICIKN-----LLWP-EVRD 409

  Fly   329 FLNISLGSKF---YYSGRTELQAVQESKQRGRIHKVFVRSPSKRLLG----AAGGVGTSGSSGGT 386
            |....|||..   ...|..:|.....:.:.|    :.|.|...:|.|    |..||.|     |:
  Rat   410 FWEKKLGSCLTTEEEGGHVDLFVPLGASETG----IEVLSLLSQLTGTSFSAPAGVAT-----GS 465

  Fly   387 PMQQHSGSESANSHNNGKPAGAGTILTITKTSRPHDNKVTSKEADSMPRKAWEQQSD--EYDIQL 449
            .:.||..|:....|.:|.|.....|          ::|:          :||...::  |..::.
  Rat   466 YLTQHILSDWLGPHRDGTPLSNYFI----------ESKL----------QAWSSFTEFLEDTLKS 510

  Fly   450 DVGFIEQCTRRFESASPSPM--PPAYSSGQHSPIL----LPTTIADAVGHQQPESGSD------- 501
            ... :.:.:|....||.:.|  ...:.:.....||    :...:||.:...|.:.. |
  Rat   511 VRKXLSRSSRTCRRASVARMIGSSCFDTLGMDSILNNQGVAQALADGLMSCQKKGLXDKPLEFLS 575

  Fly   502 --LI--TIRLQADEQGRYGFNVKGGVDL--SLPVQVSKVVPHTPADRCTPRV------------- 547
              |:  :.:...|.:|.|....:|..:.   |..:.|.:..::...:.:||.
  Rat   576 YFLLKKSSKKNEDFEGDYVLTERGLKETQDXLMKERSSIEDNSQDTKSSPRQSNLNMEALTTLER 640

  Fly   548 -CEGDEV---------LMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLLLEEEP 602
             .:.|.|         |:.:.|     |:.|.:.::||          :..||.|:|
  Rat   641 RLQMDSVEKRTRVVKELVQSER-----RYVQTLGIVRD----------VYARPLRAA-------- 682

  Fly   603 LYQYVPESDEIGSHSNLLDGDALFTQSLLLLS------DGLAS------------------GALL 643
                :..:..|.|.:|:   ..:|:.:|.:|:      |.|..                  |:.|
  Rat   683 ----LSSNRAILSAANI---HIIFSDTLHILNLNREFLDNLRDRLQEWSPAHCVGEIFIKFGSQL 740

  Fly   644 AQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLT----------GDYINANY 698
            ..|...:...|.:..|..:....||..| ..:..:|.|.|:.:.||.          .:||:..|
  Rat   741 NVYTNFFNNYPVVLKTIEKCREMAPAFR-AFLKRHDRTIVTKMLSLPELLLYPSRRFEEYIHLLY 804

  Fly   699 -VNMEIPGGAVNR---------------YI-------ATQGPLASTTTDFWRM-VQQESSHLLVM 739
             :.:..|.|.|:|               ||       ..:..|:...|..|.. ...|::..|:.
  Rat   805 ALRLHTPAGHVDRGNLTTAIEQIKKYKDYIDQIKENFKMREQLSDIQTLIWGCPTLSEANRYLIR 869

  Fly   740 LTTVMESGRQKCHQYWPVTGEELQLAE---GFSVRCLSEKPDETGSFVFREFVLKDKHEQRHIHH 801
            :..|:                :||..|   .|.:| |.|:..:...|:|.:.:|.......|
  Rat   870 IQDVV----------------QLQCCEEKTEFYLR-LYEQTQDLSLFLFSDVLLVTSRSTSH--- 914

  Fly   802 MQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEES--LKQVRLMDADADADENGGLMRER 864
                      .|.:......:......|..|.|:::|.:|  :|...::         .||.|:.
  Rat   915 ----------TPFEKTCKTTYRFSASVALPRVLIEDIPDSRYIKNAFVL---------RGLKRDW 960

  Fly   865 KCAASNGATPEDE 877
            .||..   :|:|:
  Rat   961 ICATE---SPDDK 970

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	47/242 (19%)
		FERM_N	38..102	CDD:286467	18/94 (19%)
		FERM_M	125..232	CDD:278785	22/113 (19%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	25/131 (19%)
		FA	333..369	CDD:285894	8/38 (21%)
		PDZ_signaling	502..589	CDD:238492	17/113 (15%)
		Y_phosphatase	666..955	CDD:278528	48/251 (19%)
		PTPc	668..955	CDD:238006	47/249 (19%)
Ect2l	XP_038949113.1	F-box-like	93..130	CDD:403981	6/36 (17%)
		DUF4347	302..499	CDD:405015	49/238 (21%)
		RhoGEF	653..835	CDD:395496	39/212 (18%)
		PH-like	<894..982	CDD:418428	18/102 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910