DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and USH1C

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_016872564.1	Gene:	USH1C / 10083	HGNCID:	12597	Length:	956	Species:	Homo sapiens

Alignment Length:	437	Identity:	86/437 - (19%)
Similarity:	147/437 - (33%)	Gaps:	170/437 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   478 HSPILLPTTIADAV------GHQ------QPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQ 530
            :.|..||  :.||:      .||      .|.....|..:||........|.:|:||::....:.
Human    51 NEPSRLP--LFDAIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLF 113

  Fly   531 VSKVVPHTPADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIR-------DCRHQASGELLLTV 588
            :|.::....||....:|  |||::.|||..:....||:|:.:||       ..||       :.:
Human   114 ISHLIKGGQADSVGLQV--GDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRH-------IGL 169

  Fly   589 RPQRSAPLLLEEEPL-YQYVPE--------SDEIGSHSNLLDGDALFTQSLL---LLSDGLASGA 641
            .|.:|:|    :||| :|||.:        ...:||..|..:.:.....||:   .|...::||.
Human   170 IPVKSSP----DEPLTWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGP 230

  Fly   642 LLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEIPGG 706
            :         :.|.:.|:.. ||.:....               |....||.|      :|:.|
Human   231 I---------QKPGIFISHV-KPGSLSAE---------------VGLEIGDQI------VEVNG- 263

  Fly   707 AVNRYIATQGPLASTTTDFWRMVQQESSHLL-----VMLTTVMESGRQKCHQYWPVTGEELQLAE 766
                            .||..:..:|:.::|     :.::.|..:||:
Human   264 ----------------VDFSNLDHKEAVNVLKSSRSLTISIVAAAGRE----------------- 295

  Fly   767 GFSVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARN 831
                                                               ||:...||:..||.
Human   296 ---------------------------------------------------LFMTDRERLAEARQ 309

  Fly   832 RTLLQEIEESLKQVRL-MDADADADENGGLMRERKCAASNGATPEDE 877
            |.|  :.:|.|.|.|| |:::....|...:.|:|:...:..|..|:|
Human   310 REL--QRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENE 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894
		PDZ_signaling	502..589	CDD:238492	24/93 (26%)
		Y_phosphatase	666..955	CDD:278528	33/218 (15%)
		PTPc	668..955	CDD:238006	33/216 (15%)
USH1C	XP_016872564.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910