DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and PTPRU

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_016855481.1	Gene:	PTPRU / 10076	HGNCID:	9683	Length:	1452	Species:	Homo sapiens

Alignment Length:	525	Identity:	129/525 - (24%)
Similarity:	194/525 - (36%)	Gaps:	157/525 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   499 GSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSK--------------VVPHTPADRCTPRVCE 549
            |:.::.||...|... |.:..|       ||.::|              .|..:..|:.|   .:
Human   764 GAIIVIIRKGRDHYA-YSYYPK-------PVNMTKATVNYRQEKTHMMSAVDRSFTDQST---LQ 817

  Fly   550 GDEVLMINGRDVHG--LRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLLLEEEP-----LYQYV 607
            .||.|.::..|.||  .|.:|....:.:......|.      |:|  |...:..|     |:..|
Human   818 EDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGS------PRR--PCGRKGSPYHTGQLHPAV 874

  Fly   608 PESDEIGSHSNLLDGDALFTQSLLLLSDGLASG-ALLAQYELMYRKNPDLAITEARKPANAPK-N 670
            ..:|.: .|.|.:.               .|.| ....:||..:..      .:|.|..:..| :
Human   875 RVADLL-QHINQMK---------------TAEGYGFKQEYESFFEG------WDATKKKDKVKGS 917

  Fly   671 RYRDISPYDCTRVSL---VNSLTGDYINANYVNMEIPGGAV---NRYIATQGPLASTTTDFWRMV 729
            |...:..||..||.|   :.....|||||||:::.|.....   |.:||||||......||||||
Human   918 RQEPMPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMV 982

  Fly   730 QQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLK--- 791
            .||....:||:|.::|.||.||.:|||...:...     .::.:..|.:....:|.|.|.|:
Human   983 WQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYG-----DIKIMLVKTETLAEYVVRTFALERRG 1042

  Fly   792 --DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADA 854
              .:||.|..|   :.|||:|.||......|.|..||:|
Human  1043 YSARHEVRQFH---FTAWPEHGVPYHATGLLAFIRRVKA-------------------------- 1078

  Fly   855 DENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALM 919
                             :||.|.               .|:::|||||.||||..|::|..|.:.
Human  1079 -----------------STPPDA---------------GPIVIHCSAGTGRTGCYIVLDVMLDMA 1111

  Fly   920 EAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCE-----CIC-----------AAYMKISRSSAA 968
            |....|...:.|:|:..:|..|:|...||.|:.:     |:|           |.|.::.|....
Human  1112 ECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQ 1176

  Fly   969 INDDE 973
            .|..:
Human  1177 SNSSQ 1181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894
		PDZ_signaling	502..589	CDD:238492	20/102 (20%)
		Y_phosphatase	666..955	CDD:278528	87/305 (29%)
		PTPc	668..955	CDD:238006	87/303 (29%)
PTPRU	XP_016855481.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910