DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptpmeg and PTPRU

DIOPT Version :9

Sequence 1:NP_001163309.2 Gene:Ptpmeg / 38059 FlyBaseID:FBgn0261985 Length:974 Species:Drosophila melanogaster
Sequence 2:XP_016855481.1 Gene:PTPRU / 10076 HGNCID:9683 Length:1452 Species:Homo sapiens


Alignment Length:525 Identity:129/525 - (24%)
Similarity:194/525 - (36%) Gaps:157/525 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   499 GSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSK--------------VVPHTPADRCTPRVCE 549
            |:.::.||...|... |.:..|       ||.::|              .|..:..|:.|   .:
Human   764 GAIIVIIRKGRDHYA-YSYYPK-------PVNMTKATVNYRQEKTHMMSAVDRSFTDQST---LQ 817

  Fly   550 GDEVLMINGRDVHG--LRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLLLEEEP-----LYQYV 607
            .||.|.::..|.||  .|.:|....:.:......|.      |:|  |...:..|     |:..|
Human   818 EDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGS------PRR--PCGRKGSPYHTGQLHPAV 874

  Fly   608 PESDEIGSHSNLLDGDALFTQSLLLLSDGLASG-ALLAQYELMYRKNPDLAITEARKPANAPK-N 670
            ..:|.: .|.|.:.               .|.| ....:||..:..      .:|.|..:..| :
Human   875 RVADLL-QHINQMK---------------TAEGYGFKQEYESFFEG------WDATKKKDKVKGS 917

  Fly   671 RYRDISPYDCTRVSL---VNSLTGDYINANYVNMEIPGGAV---NRYIATQGPLASTTTDFWRMV 729
            |...:..||..||.|   :.....|||||||:::.|.....   |.:||||||......||||||
Human   918 RQEPMPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMV 982

  Fly   730 QQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLK--- 791
            .||....:||:|.::|.||.||.:|||...:...     .::.:..|.:....:|.|.|.|:   
Human   983 WQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYG-----DIKIMLVKTETLAEYVVRTFALERRG 1042

  Fly   792 --DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADA 854
              .:||.|..|   :.|||:|.||......|.|..||:|                          
Human  1043 YSARHEVRQFH---FTAWPEHGVPYHATGLLAFIRRVKA-------------------------- 1078

  Fly   855 DENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALM 919
                             :||.|.               .|:::|||||.||||..|::|..|.:.
Human  1079 -----------------STPPDA---------------GPIVIHCSAGTGRTGCYIVLDVMLDMA 1111

  Fly   920 EAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCE-----CIC-----------AAYMKISRSSAA 968
            |....|...:.|:|:..:|..|:|...||.|:.:     |:|           |.|.::.|....
Human  1112 ECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQ 1176

  Fly   969 INDDE 973
            .|..:
Human  1177 SNSSQ 1181

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PtpmegNP_001163309.2 B41 35..232 CDD:214604
FERM_N 38..102 CDD:286467
FERM_M 125..232 CDD:278785
FERM_C_PTPN4_PTPN3_like 226..320 CDD:270010
FA 333..369 CDD:285894
PDZ_signaling 502..589 CDD:238492 20/102 (20%)
Y_phosphatase 666..955 CDD:278528 87/305 (29%)
PTPc 668..955 CDD:238006 87/303 (29%)
PTPRUXP_016855481.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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