DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and fgd1

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_004914246.1	Gene:	fgd1 / 100489369	XenbaseID:	XB-GENE-6453246	Length:	913	Species:	Xenopus tropicalis

Alignment Length:	419	Identity:	88/419 - (21%)
Similarity:	151/419 - (36%)	Gaps:	115/419 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 PSRLQE-EFT-RYQFY------LQ-----IKRNILLGKLPCS-----SNTQCLLASYTVQSELGD 170
            |.||.. ||| |.:.|      ||     :.|..||.::.|:     :.|:   ||:.|:..:|.
Frog   326 PERLDPCEFTARQKVYKIANELLQTEKAYVSRLHLLDQVFCARLMDEARTR---ASFPVEVVMGI 387

  Fly   171 FNAL-----EHQPGYLSGMQLLCDQTTEAERKVGE-LHKLHRGQLPADAEYNYLEHAKR----LE 225
            |:.:     .||...|..::... |..::..::|: |.||      |.....|.|:.|.    :|
Frog   388 FSNICSIYCFHQQFLLPELEKRM-QEWDSNPRIGDILQKL------APFLKMYGEYVKNFDRAME 445

  Fly   226 LYGIDLHRATDSNG--KELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSFKRKDFFIQLRREPSE 288
            |..:...|::....  :|:| ...|.|.|..||.:....   .::.:.....||:.::|..:..:
Frog   446 LLNVWTERSSQFKSVIQEVQ-REEACGNLTLQHHMLEPV---QRIPRYELLLKDYLLKLPEDSKD 506

  Fly   289 NYDTLLGFGMSSHKHAKALWKSCVEHH--SFFRLKRPHRLSRFLNISLGSKFYYSGRTELQAVQE 351
            ..|.         :.:..|..:..||.  :..:::|.|:|.:...:..|.:...|...||  ::|
Frog   507 RCDA---------EKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTNEL--IKE 560

  Fly   352 SKQRGRIHKVFVRS-------------------PSKRLLGAAGGVGTSGSSGGTPMQQHSGSESA 397
                |.|.|:..::                   |..||:|....|.......|..: :||.|.:
Frog   561 ----GHILKLSAKNGTTQDRYLILFNDRLLYCVPKLRLIGQKYSVRARIDVEGMEL-KHSSSPN- 619

  Fly   398 NSHNNGKPAGAGTILTITKTSRPHDNKVTSKEADSM---PRKAWEQQSDEYDIQLDVGFIEQ--- 456
                            :|:|.|. ..|..|.|..:.   .:|.|.|.     |:..:...||
Frog   620 ----------------LTRTFRV-SGKQRSLELQARTEEEKKDWIQA-----IEATINRHEQAME 662

  Fly   457 -----CTRRFESASPSPMPPAYSSGQHSP 480
                 ||...|.....|..|....|:.:|
Frog   663 SCKLLCTSIREDEETPPNSPNTDLGKRAP 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	34/135 (25%)
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785	33/134 (25%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	16/97 (16%)
		FA	333..369	CDD:285894	9/54 (17%)
		PDZ_signaling	502..589	CDD:238492
		Y_phosphatase	666..955	CDD:278528
		PTPc	668..955	CDD:238006
fgd1	XP_004914246.1	PHA03247	<6..207	CDD:223021
		RhoGEF	341..525	CDD:238091	42/206 (20%)
		PH1_FGD1	557..664	CDD:275392	26/136 (19%)
		FYVE_FGD1_2_4	691..755	CDD:277280	1/1 (100%)
		PH2_FGD1-4	780..885	CDD:270056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910