Protein Alignment Ptpmeg and ptpn14

DIOPT Version :9

• Sequence 1: NP_001163309.2
• Gene: Ptpmeg / 38059
• FlyBaseID: FBgn0261985
• Length: 974
• Species: Drosophila melanogaster
• Sequence 2: XP_031758936.1
• Gene: ptpn14 / 100379917
• XenbaseID: XB-GENE-985641
• Length: 1176
• Species: Xenopus tropicalis
• Alignment Length: 1272
• Identity: 271/1272 - (21%)
• Similarity: 452/1272 - (35%)
• Gaps: 428/1272 - (33%)

  Fly    20 GPELARDKK-TPQRQQC--VTVLFLD--DITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLF 79
            |.:|.|.|: ....:.|  |.:..||  ::.:|..::  :.|.|.|:.|.|.|||.|...|||.:
 Frog     4 GLKLRRTKRYNVLSKNCFVVRIQLLDNSEVEYTRTVD--STGLECLEAVAQRLELCEIHCFGLQY 66

  Fly    80 PQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVP-LLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRN 143
            ..| .:.:|||:.:|..|||     ||..|.. |:.|.:.::|.:.|.|::..||.|:|||:|::
 Frog    67 VGK-NNQMRWVELEKSLKKQ-----LDKFANKFLVFFGIMYYVPNVSYLKQPTTRTQYYLQLKKD 125

  Fly   144 ILLGKLPCSSNTQCLLASYTVQSELGDFNAL--EHQPGYLSGMQLLCDQTTEAE-------RKVG 199
            :..|:|..|:.....||...:::|:.||:.|  .|   :|....|.....|:.|       .||.
 Frog   126 VYEGRLCGSAEQYFRLAGLALRAEIKDFDLLGTYH---FLKDYTLFPQAWTKDEAMLEGLCHKVA 187

  Fly   200 ELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVN-TF 263
            ..:|...|...|:||..||:.|:.::.||.:.....|::|.::.|.:|.:|:.:..:..:.. |:
 Frog   188 LEYKALSGIPSAEAEILYLKEAEHMDGYGQESFHMKDNHGNDINLCISFMGIFIRNNCRQATATY 252

  Fly   264 SWSKMVKVSFKRKDFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKR------ 322
            .||.:..::..:....::|.|:     :.::.|.....:::|.:.:.....|.|::..:
 Frog   253 RWSDIGNITHNKSAIVLELNRK-----EEVVVFSTDDIENSKYITRLFAARHKFYKDNKICTEQS 312

  Fly   323 --PHRLSRFLNISLGS-------------------------------KFYYSGRTELQA------ 348
              |..:.|..|.:..|                               .|.|..:|.|..
 Frog   313 SSPPAVRRQPNWNRSSMSRQQTILPPRHIHGGETYISEDNIFHMNEDAFNYRSQTSLDRYLDPNF 377

  Fly   349 -------------------------VQESKQRGRI-----------------HKVFVRSPSKRLL 371
                                     :|.|.....:                 |...: :||.|..
 Frog   378 INGTLVNGSDSSAHSINSLNRSQNFIQASPMSSSLSIQSNDIMRADYIPSYRHSAII-APSYRPT 441

  Fly   372 GAAGGVGTSGSSGGTPMQQHS--------GSESANSHNNG------------------KPAGAGT 410
            .....|....:.|..||...|        |:..|..|...                  .|..|.|
 Frog   442 PDYETVMRQMNRGIIPMDCQSQSLRNLNIGNTHAYRHRENLVYSQPEIQERHAYVPPYVPQTAYT 506

  Fly   411 ILTITKTSRPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSS 475
            .:.|....:.:..||||.:|.::.......:......|. |.......:.|.|..|.|.||...:
 Frog   507 NVLINPIEQINPTKVTSNQAKAISHTVSTPELANVPPQA-VQSAALMLKNFLSRPPPPYPPTRPA 570

  Fly   476 GQHSPILLPTTIADAVGHQQPE-SGS--DLITIRLQADEQGRYGFNVKGGVDLSLPV------QV 531
                     ::..|...|:|.. |||  ||:|.::|.        :||...:.|.||      :|
 Frog   571 ---------SSTPDLASHRQKRVSGSSPDLVTRKVQQ--------SVKTFQEDSAPVVHQSLQEV 618

  Fly   532 SK----VVPHTPADRC-----TPRVCEGDEVLMINGRDVHGLR----HEQV-------------- 569
            |:    |.||...::|     ...:..|.|.:.:...:.|..|    .|||
 Frog   619 SEPLMMVKPHPSVNKCHSFEVITNMVRGMEAMALKTMNAHLPRRNTLREQVPTEESMQKAHEVQQ 683

  Fly   570 ------------------------------------------------VAMIR------------ 574
                                                            .|:.|
 Frog   684 LPMYHHKKNISDATMLILSSESEEEEEPHKSVSPTSPLQGMAYSAQLQAALARIPKKPPPEYPGP 748

  Fly   575 -------DCRHQASGELLLTVR----------------------------PQRSAPLL------L 598
                   ..||::|....:..|                            |..|.|.|      :
 Frog   749 RKSISNGALRHESSNISSVIARAKAMSQRPCQAACISKTEPAAMNGSSLGPSISEPDLTCVKERI 813

  Fly   599 EEEPLYQYVPESDEIGSHSNLLDGD------------ALFTQS---LLLLSDGLA---------- 638
            ::||:.:. |.|:.......:::.:            ||..|.   ::...:||:
 Frog   814 KKEPVKER-PVSEMFSIEDVIVEREIMMRNLEKQEMAALEAQKRPLMMAALNGLSVSRIARPEDR 877

  Fly   639 ---------------------SGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTR 682
                                 .|.:..:||.:.::.|:...|.|..|.|..:||..:..||:..|
 Frog   878 QDDTALIQMDERCKTLRWRLEEGMVFTEYEQIPKRKPEGVFTTAVLPENLERNRICEDIPYEENR 942

  Fly   683 VSLV---NSLTGDYINANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVM 744
            |.||   .:.|| ||||:::.:.:.|...: ||||||||..|..|||:||.::..:::.|:....
 Frog   943 VELVPTKENPTG-YINASHIKVTVSGKDWH-YIATQGPLPHTFHDFWQMVWEQGVNVIAMVNADE 1005

  Fly   745 ESGRQKCHQYWPVTGE--------ELQLAEGFSVRCLSEKPDETGSFVFREFVLKDKH----EQR 797
            |.||.|.|:|||..|.        :.::...|          .|.|..:....||.||    ::|
 Frog  1006 EEGRAKSHRYWPKLGTKHNSETYGKFKVTTNF----------RTDSGCYATTGLKVKHLLTGQER 1060

  Fly   798 HIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGLMR 862
            .:.|:|:..||||..|.:...||.:.|.:|:.|..
 Frog  1061 TVWHLQFTDWPDHGCPDEMQGFLSYLEEIRSVRRH------------------------------ 1095

  Fly   863 ERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYP 927
                     |.|.             |..||||:||||||:|||||::|.:..:..:|..|.:..
 Frog  1096 ---------ANPS-------------SLCNPPVVVHCSAGVGRTGVVVLTELMIRCLENNENIEI 1138

  Fly   928 LDIVRTMRDQRACMVQNVSQYRFVCECICAAYMKISR 964
            ..::|.:|:||..|:|.::||.||.: :...::|.||
 Frog  1139 PAMLRHLREQRMFMIQTIAQYTFVYQ-VLIYFLKSSR 1174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	66/210 (31%)
		FERM_N	38..102	CDD:286467	23/65 (35%)
		FERM_M	125..232	CDD:278785	35/115 (30%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	16/94 (17%)
		FA	333..369	CDD:285894	10/114 (9%)
		PDZ_signaling	502..589	CDD:238492	26/186 (14%)
		Y_phosphatase	666..955	CDD:278528	91/303 (30%)
		PTPc	668..955	CDD:238006	90/301 (30%)
ptpn14	XP_031758936.1	FERM_F1_PTPN14_like	18..102	CDD:340619	30/91 (33%)
		B41	22..220	CDD:214604	65/208 (31%)
		FERM_C_PTPN14_PTPN21	215..305	CDD:270009	16/94 (17%)
		PTPc-N14	889..1171	CDD:350447	98/346 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910