DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and snta1

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_002662604.4	Gene:	snta1 / 100332905	ZFINID:	ZDB-GENE-120919-5	Length:	479	Species:	Danio rerio

Alignment Length:	536	Identity:	111/536 - (20%)
Similarity:	185/536 - (34%)	Gaps:	189/536 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   462 ESASPSPMPPAYSSG-----QHSPILLPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVKG 521
            ||||.||.|.|..:|     ..||:  |.||.:...           |:|:...|.|..|.::||
Zfish    44 ESASNSPAPGAAVNGDPANLSASPV--PDTITNVKR-----------TVRVTKQEVGGLGISIKG 95

  Fly   522 GVDLSLPVQVSKVVPHTPADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLL 586
            |.:..:|:.:||:.....||: |..:..||.:|.:||.|:....|::.|..::    :...|::|
Zfish    96 GKENKMPILISKIFKGLAADQ-TEALYVGDAILSVNGNDLREATHDEAVQALK----KTGKEVIL 155

  Fly   587 TVRPQRSAPLLLEEEPLYQYVPESDEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYR 651
            .|:                |:.|.            .|.|       ..|.....:|.......:
Zfish   156 EVK----------------YIKEM------------SAFF-------KGGSTGPPVLDSPPATPQ 185

  Fly   652 KNPDLAITEARK-------------PANAPKNRYRDISPYD-----------------------C 680
            |..|.|:.|.|.             |.: |::||.::...|                       .
Zfish   186 KQTDPALKETRTIPLRMCHVTRKQCPPD-PEDRYFEVVSSDRKTSVFLRAKDHAMAQAWYNSIQS 249

  Fly   681 TRVSLVNSLTGDY------INANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMV---------- 729
            :..:|:|:...:.      :|..::...|..|       ::.|:.:..||...::
Zfish   250 SSAALLNTAKDELKTLQPSLNIKHIGWIIEQG-------SERPILAVLTDRDLLLYGALPDSKET 307

  Fly   730 --QQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLKD 792
              ..:.|:.|: .|.::.||..|...   |...||.    |.:|..:::..||  .:||....||
Zfish   308 LNSPDKSYPLI-TTRLVHSGPGKSSS---VHDSELT----FGLRLGTKQGVET--HLFRVDSAKD 362

  Fly   793 KHEQRHI-----HHMQYL--------AW-PDHCVPS-----DPNLFLEFTERVRAARNRTLLQEI 838
            .....|:     |....|        :| ...|:.|     ..:||:|..    ..:...|||:.
Zfish   363 LSCWTHLLVDGCHSAAELVQEVITACSWNGKSCMLSVHIDRGFSLFMEDC----GVKKSVLLQQP 423

  Fly   839 EESLKQ-----VRLMDADADADENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANPPV--- 895
            .|.|:.     ||::..|.     ||              |:.|  :...:|.|     |..
Zfish   424 FERLRMSSDDGVRMIFLDF-----GG--------------PDAE--IQLDLHSC-----PKTMVF 462

  Fly   896 IVH--CSAGIGRTGVL 909
            |:|  .||.:.|.|:|
Zfish   463 IIHSFLSAKVKRLGLL 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894
		PDZ_signaling	502..589	CDD:238492	24/86 (28%)
		Y_phosphatase	666..955	CDD:278528	60/314 (19%)
		PTPc	668..955	CDD:238006	60/312 (19%)
snta1	XP_002662604.4	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910