DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and epb41l4b

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_005158090.1	Gene:	epb41l4b / 100332627	ZFINID:	ZDB-GENE-100921-92	Length:	729	Species:	Danio rerio

Alignment Length:	620	Identity:	182/620 - (29%)
Similarity:	263/620 - (42%)	Gaps:	125/620 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 VLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSS 102
            ||.||.......:.|.|||.:|.||:..:|:|.|.|||||.| ..|..|..|:||.|..|||
Zfish    72 VLLLDGSDVNVELPKHAKGQDLFDQIMYHLDLVEADYFGLQF-MDPEQVAHWLDAAKPIKKQ--- 132

  Fly   103 VSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSE 167
              :.:.....|.|||||:.|:|:.|.||||||.|.||::::||.|||.|..:....|.:|.:|||
Zfish   133 --IRHGPPYRLFFRVKFYSSEPNNLHEEFTRYLFVLQLRQDILSGKLKCPYDVSVELGAYCLQSE 195

  Fly   168 LGDFNALEHQPGYLSGMQLLCDQTTEAERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLH 232
            |||.:.|||....:|..:....||...|..:.......||.:|:.||.|:|...|.||:||:|:|
Zfish   196 LGDCDPLEHSILLVSEFRFSPKQTEIMEADIYRKWVECRGMIPSQAELNFLNKCKWLEMYGVDMH 260

  Fly   233 RATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSFKRKDFFIQLRR--EPSENYDTLLG 295
            .....:|.|..||::..|:|||:.|.::..|.|.|:.::.|||....:.:..  |.....:....
Zfish   261 FVKGRDGGEYALGLTPTGILVFEGSSKIGLFFWPKITRLDFKRNRLTLVVVEDDEKGREQEHTFV 325

  Fly   296 FGMSSHKHAKALWKSCVEHHSFFRLKRP--HRLSRFLNISLGSKFYYSGRTELQAVQESKQRGRI 358
            |.:||....|.|||..||.|:||||::|  ::.||.....|||:|.:|||||.||....|.|..
Zfish   326 FQLSSSHECKHLWKCAVESHAFFRLRQPTHNKTSRSDFTRLGSRFRFSGRTEYQATHSGKVRRA- 389

  Fly   359 HKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQHSGSESANSHNNGKPAGAGTILTITKTSRPHDN 423
             ..|.|.||||.                |.:..|                 .:..:|....||.:
Zfish   390 -STFERRPSKRY----------------PSRAQS-----------------MVKAMTPAKHPHLS 420

  Fly   424 KVTSKEADSMPRK--------AWEQQSDEYDIQLDVGFIEQCTRRFESASP---SPMPPAYSSGQ 477
            ..||.|....|.|        .|::......:                .||   .||...::...
Zfish   421 AQTSPEPSLKPYKHNIPIAQDPWQRSHPPPSL----------------TSPLYIQPMELGHTPPP 469

  Fly   478 HSPILLPTTIADAVGHQQPESGSDLITIRLQADEQGR-------YGFNVKGGVDLSLPVQVSKVV 535
            ||   .|.:.||.......|:         :|...|:       :|:..:..:.|:.....:.||
Zfish   470 HS---FPLSAADTRRFSVEEN---------EAPHSGKIHRCYHHHGYEKQEPLCLTTAKPKAWVV 522

  Fly   536 PHTPA-----DRCTPRVCEGD----EVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQ 591
              :||     ||......|.:    ..|.||            :.|        :.|..|:.:..
Zfish   523 --SPALSDELDRALQNQLEAEPAAWPALHIN------------IDM--------AEEKPLSEKSL 565

  Fly   592 RSAPLLLEEE---PLYQYVPESDEIGSHSNLLDGD 623
            .|:|.:|:|:   .:.:...:||...|..|...||
Zfish   566 PSSPAVLQEQLKSNISKRATQSDSGNSKGNSSSGD 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	81/193 (42%)
		FERM_N	38..102	CDD:286467	29/63 (46%)
		FERM_M	125..232	CDD:278785	44/106 (42%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	32/95 (34%)
		FA	333..369	CDD:285894	17/35 (49%)
		PDZ_signaling	502..589	CDD:238492	17/102 (17%)
		Y_phosphatase	666..955	CDD:278528
		PTPc	668..955	CDD:238006
epb41l4b	XP_005158090.1	B41	69..260	CDD:214604	81/193 (42%)
		FERM_N	72..134	CDD:286467	29/67 (43%)
		FERM_M	153..260	CDD:278785	44/106 (42%)
		FERM_C_NBL4_NBL5	256..349	CDD:270007	30/92 (33%)
		FA	362..402	CDD:285894	19/57 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910