DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and frmd3

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_002663277.2	Gene:	frmd3 / 100331256	ZFINID:	ZDB-GENE-070523-1	Length:	603	Species:	Danio rerio

Alignment Length:	607	Identity:	173/607 - (28%)
Similarity:	267/607 - (43%)	Gaps:	115/607 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 QCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKK 98
            || ||..|||...:..|::..||..|:|.|..:..|.|:||||:.:.. |.....|:|..|...|
Zfish    19 QC-TVRLLDDSEISCSIQRDTKGQFLVDHVCNHYSLLEKDYFGIRYVD-PDKQRHWLDPSKPVVK 81

  Fly    99 Q--CSSVSLDNDAVP-LLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLA 160
            |  |..        | .:.|||||:..:|.:::||.|||..|||:||::..|:|.|.......|.
Zfish    82 QMKCQQ--------PYTMCFRVKFYPQEPIKIKEELTRYLLYLQLKRDVYHGRLLCPFADAAYLG 138

  Fly   161 SYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEAERKVGELHKLH-RGQLPADAEYNYLEHAKRL 224
            :..||:||||::..||...|:|..:|...|:.:.|||:.|:|:.. |||.|:.||.|.|:.|..|
Zfish   139 ACIVQAELGDYDPEEHPADYISDFKLFPKQSLKLERKIMEIHQNELRGQCPSLAELNLLQRAHTL 203

  Fly   225 ELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSFKRKDFF-IQLRREPSE 288
            :.||:|.|...|..|....||.:|.|.:|||.:.|::...|:.:.|..|:.|.|: |.::||..
Zfish   204 DTYGVDPHPCKDFTGSTAFLGFTARGFVVFQGNKRIHLLKWADVSKFKFEGKTFYVIGVQREKK- 267

  Fly   289 NYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSRFLNISL---GSKFYYSGRTELQAVQ 350
               .:|.|..|:....|.|||..||:.:|::..:..::....:.|:   ||:|.||||...:.::
Zfish   268 ---LVLTFHTSTPAACKHLWKCGVENQAFYKCAKSSQIKTVSSSSIFFKGSRFRYSGRVAKEVIE 329

  Fly   351 ESKQRGR----IHKV-FVRSPSKRLLGAAGGVGTSGSSGGTPMQQHSGSESANSHNNGKPAGAGT 410
            .|.:..|    :|:. |.:|.|          .||.|.....|.......:.:|....:.:.|..
Zfish   330 ASSKIQRDPPVVHRCQFGQSRS----------FTSLSHKQLIMNMEPLLPALSSSRESRDSSADN 384

  Fly   411 ILTITKTS---RPHDNKVTSKEA--DSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMP 470
            .|:..|..   .|....||.:||  :.|...:.|::.||...:..|   ::..|.....|....
Zfish   385 GLSALKDCVHLSPLKPSVTPEEAEMEEMLNFSQERREDEASQRTRV---DEDRREIHVDSEDDT- 445

  Fly   471 PAYSSGQH-------SPI--LLPTTIADAVG-----HQQPESGSDLITIRLQADEQGRYGFNVKG 521
               |.|.|       ||.  |:||.:.:|.|     .|.|..    :...|.||.
Zfish   446 ---SGGAHTISDTAYSPCASLVPTPVEEAQGGLELLFQSPAR----LLKELHADP---------- 493

  Fly   522 GVDLSLPVQVSKVVPHTPADR-------CTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRH- 578
              |:...:|..:   ...|:|       |:|.          :||       :|:.|.:|....
Zfish   494 --DMQRELQAER---QREAEREAFRQSLCSPS----------SGR-------QQMQACLRSAARL 536

  Fly   579 --QASGELLLTVRPQRSAPLLL 598
              .|:|.|::.:      ||||
Zfish   537 VLMATGLLMILL------PLLL 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	76/200 (38%)
		FERM_N	38..102	CDD:286467	23/65 (35%)
		FERM_M	125..232	CDD:278785	44/107 (41%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	32/94 (34%)
		FA	333..369	CDD:285894	14/43 (33%)
		PDZ_signaling	502..589	CDD:238492	17/96 (18%)
		Y_phosphatase	666..955	CDD:278528
		PTPc	668..955	CDD:238006
frmd3	XP_002663277.2	B41	20..211	CDD:214604	76/200 (38%)
		FERM_N	22..85	CDD:286467	22/63 (35%)
		FERM_M	104..211	CDD:278785	44/106 (42%)
		PH-like	192..295	CDD:302622	38/106 (36%)
		FA	310..356	CDD:285894	15/55 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910