DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptpmeg and trio

DIOPT Version :9

Sequence 1:NP_001163309.2 Gene:Ptpmeg / 38059 FlyBaseID:FBgn0261985 Length:974 Species:Drosophila melanogaster
Sequence 2:XP_012819807.1 Gene:trio / 100170157 XenbaseID:XB-GENE-922516 Length:3085 Species:Xenopus tropicalis


Alignment Length:1145 Identity:208/1145 - (18%)
Similarity:347/1145 - (30%) Gaps:427/1145 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 PELARDKKTPQRQ--QCVTVLFLDD--ITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQ 81
            |.:....|.|::|  ..:..||..:  :.|.:.:.||.     ||...||          ::|.:
 Frog  1091 PGMVTHVKAPEQQVKNILNELFQRENRVLHYWTLRKRR-----LDHCQQY----------VVFER 1140

  Fly    82 KPGDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQ---------EEF--TRYQ 135
            .....:.|:.              ||.     ||.:....|..|.:|         |||  |..|
 Frog  1141 SAKQALEWIQ--------------DNG-----EFYISTHTSTGSTIQHTQELLKEHEEFQITAKQ 1186

  Fly   136 FYLQIKRNILL-------GKLPCSSNTQCLLASYTVQSELGDFN--------ALEHQPGYLS--- 182
            ...::|..|.|       |....:...:|:.|   |.....||:        :||...|..|   
 Frog  1187 TKERVKLLIQLADGFCEKGHAHAAEIKKCVTA---VDKRYRDFSLRMEKYRTSLEKALGISSDSK 1248

  Fly   183 ---GMQL-------------LCDQTTE--------AERK-------------------------- 197
               .:||             |.|.|.|        |.||                          
 Frog  1249 SSKSLQLDIIPATAPGSEVKLRDATHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYL 1313

  Fly   198 ------------------------VGELHKLHRG----------QLPADAEYNYLEHAKRLELYG 228
                                    :.|:::.|..          |||.|..:.::..|.:.::|.
 Frog  1314 WEMTSGVEEIPPGIVNKEHIIFGNMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYV 1378

  Fly   229 IDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSFKRKDFFIQLRREPSE---NY 290
            .......||....|:...:....:..:|.| ||:.| |.::|               |.:   .|
 Frog  1379 SYCKNKPDSTQLILEQAGTYFDEIQQRHEL-VNSIS-SYLIK---------------PVQRITKY 1426

  Fly   291 DTLLGFGMSSHKHAKALWKSCVEHHSFFR------LKRPHRLSRFLNISLGSKFYYSGRTELQAV 349
            ..||          |.|...|.|.....:      |..|.|.:..:::|:...|..:..::.:.:
 Frog  1427 QLLL----------KELLTCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELI 1481

  Fly   350 -QESKQ---------RGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQHSGSE-SANSHNNG 403
             |||.|         :||...:|:...|  |:.:.....:||.|......:...|| ....|..|
 Frog  1482 LQESFQVWDPKTLIRKGRERHLFLFEMS--LVFSKEVKDSSGRSKYIYKSKLFTSELGVTEHVEG 1544

  Fly   404 KPAGAGTILTITKTSRPHDNKVTSKEADSMPRKAW----EQQSDEYDIQLDVGFIEQCTRRFESA 464
            .|......:..|.||   |||:..|.:....::.|    .:...:..|.|. |.:::.....::|
 Frog  1545 DPCKFALWVGRTPTS---DNKIVLKGSSIENKQDWIKHIREVIQDRTIHLR-GALKEPIHIPKTA 1605

  Fly   465 SPSPMPPAYSSGQHSPILLPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPV 529
            :.:...||...|:...       :...|..||    |.|:|..:..:.......:.||.:|:   
 Frog  1606 AATKQKPAKRDGEDLD-------SQGDGSSQP----DTISIASRTSQNTLDSDKLSGGCELT--- 1656

  Fly   530 QVSKVVPHTPADRCTPRVCEGDEVLMINGRDVHGL-RHEQVV--AMIRDCRHQASGELL-----L 586
                ||.|...      .|..:|:.:..|:.|..| ||....  .::|......:.|.|     |
 Frog  1657 ----VVIHDFT------ACNSNELTIKRGQTVEVLERHHDRPDWCLVRTTDRSPAAEGLVPSSSL 1711

  Fly   587 TVRPQRSAPLLLEEEPLYQY-----VPESDE-------------IGSHSN---LLDGDAL---FT 627
            .:...||:   :|.|.::.:     |..:|.             ||:.|:   ...|:.|   .|
 Frog  1712 CIAHSRSS---MEMEGIFNHKDSLSVSSNDASPPASVISLQPHMIGAQSSPGPKRPGNTLRKWLT 1773

  Fly   628 QSLLLLSDGLASGAL--LAQYELMYRKNPDLAITEARKPANAPKNRYRDIS---PYDCTRVSLVN 687
            ..:..||.|.|.|.:  ||.   .::|:     .|.||..::...:..|.|   |.|.|      
 Frog  1774 SPVRRLSSGKADGHVKKLAH---KHKKS-----REVRKNTDSGSQKDSDDSAATPQDET------ 1824

  Fly   688 SLTGDYINANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCH 752
                                :...:..:| |:|.|                 |:....||.|.| 
 Frog  1825 --------------------IEERVRNEG-LSSGT-----------------LSKSSSSGMQSC- 1850

  Fly   753 QYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPN 817
                  |||    ||      .|.||                                .||..|.
 Frog  1851 ------GEE----EG------EEGPD--------------------------------AVPLPPP 1867

  Fly   818 LFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGLMRERKCAASNGATPEDETPVST 882
            :                      :::|..|:..|:..|:....:..|..::...:..|..:.:..
 Frog  1868 M----------------------AIQQHSLLQPDSQDDKTSSRLLVRPTSSETPSAAELVSAIEE 1910

  Fly   883 SVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPV---------------YPL-DIV 931
            .|...::..:.|..:....|...:......||  :|:.:..|:               |.| ::|
 Frog  1911 LVKSKMALEDRPSSLQVDQGDSSSPSFNPSDT--SLLSSSSPIDEMEEKKSSSLKRRHYVLQELV 1973

  Fly   932 RTMRDQRACMVQNVSQYRFVCECICAAYMKISRSSAAIND 971
            .|.||.       |....:|.|    .||.:.:.....:|
 Frog  1974 ETERDY-------VRDLGYVVE----GYMALMKEDGVPDD 2002

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PtpmegNP_001163309.2 B41 35..232 CDD:214604 53/311 (17%)
FERM_N 38..102 CDD:286467 11/65 (17%)
FERM_M 125..232 CDD:278785 37/219 (17%)
FERM_C_PTPN4_PTPN3_like 226..320 CDD:270010 19/102 (19%)
FA 333..369 CDD:285894 10/45 (22%)
PDZ_signaling 502..589 CDD:238492 19/94 (20%)
Y_phosphatase 666..955 CDD:278528 47/307 (15%)
PTPc 668..955 CDD:238006 47/305 (15%)
trioXP_012819807.1 SEC14 64..199 CDD:214706
SPEC 215..440 CDD:238103
SPEC 336..561 CDD:238103
SPEC 562..778 CDD:238103
SPEC 782..1009 CDD:238103
SPEC 903..1132 CDD:238103 11/45 (24%)
SPEC 1138..1238 CDD:197544 23/121 (19%)
RhoGEF 1289..1459 CDD:238091 29/196 (15%)
PH1_Kalirin_Trio_like 1466..1588 CDD:270060 26/126 (21%)
SH3_Kalirin_1 1654..1713 CDD:212786 15/71 (21%)
SH3-RhoG_link 1710..1967 CDD:293215 62/384 (16%)
RhoGEF 1965..2138 CDD:238091 12/49 (24%)
PH2_Kalirin_Trio_p63RhoGEF 2143..2281 CDD:270061
SH3_Kalirin_2 2543..2601 CDD:212787
I-set 2673..2764 CDD:254352
Ig 2687..2764 CDD:299845
STKc_Trio_C 2776..3038 CDD:271015
S_TKc 2784..3038 CDD:214567
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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