DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and ptprz1

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_001362251.1	Gene:	ptprz1 / 100125091	XenbaseID:	XB-GENE-1011831	Length:	2281	Species:	Xenopus tropicalis

Alignment Length:	656	Identity:	158/656 - (24%)
Similarity:	229/656 - (34%)	Gaps:	246/656 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   423 NKVTSKEAD-SMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSGQHSPILLPTT 486
            ||..|:.:: |....|:...:.:.:|..|:        ..||...:.||.:.:..:|.|...|.|
Frog  1433 NKTFSEHSEQSEDGSAFSTAAADNNIDSDM--------EGESYLSTTMPMSSTGQKHIPFTAPET 1489

  Fly   487 IADAVGHQQ--------------------PESGSDLITIRLQADEQGRYGFNVKG----GVDLSL 527
                  |.|                    .||||...|....:|.:....||...    ..|..:
Frog  1490 ------HIQTLNTLLENTSESRSWAVLTDEESGSGPSTSDSLSDNETSTDFNFSDINDRDKDYEV 1548

  Fly   528 PVQVSKVVPHTPADRCT--PRV-CEGDEVLMINGRDV-----------------HGLRHEQ--VV 570
            .:|..| ...||....|  |.| .|...|:.::..||                 .||..|:  |:
Frog  1549 AIQPGK-ADLTPGSEMTSPPSVTSERSPVVNVSEADVVNQEASNSSHESRVGLAEGLESEEKTVI 1612

  Fly   571 AMI--------------------RDC--------RHQASGELLLTVRPQRSAPLL--------LE 599
            .::                    |.|        ...||..::       |:|.:        :|
Frog  1613 PLVVVSSLTFICLVVLVGILIYWRKCFQTAHFYLEDNASSRVI-------SSPPIPVFPVADDVE 1670

  Fly   600 EEPLYQYVPESDEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAIT--EAR 662
            ..||.|:....:|:.|.:...|                       ::|.:.....||.||  .:.
Frog  1671 AIPLKQFPKHVEELHSRNGFTD-----------------------EFEEIQNCTADLGITSDNSN 1712

  Fly   663 KPANAPKNRYRDISPYDCTRVSLVNSLTG-------DYINANYVNMEIPGGAVNR---YIATQGP 717
            .|.|..||||.:|..||.:||.|  |..|       ||||||:|:      ..|:   |||.|||
Frog  1713 HPDNKNKNRYVNIVAYDHSRVKL--SQLGEKEGKATDYINANFVD------GYNKQKAYIAAQGP 1769

  Fly   718 LASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGS 782
            |.||..|||||:.:.:..::||:|.::|.||:||.||||..|.|                 |.||
Frog  1770 LKSTAEDFWRMLWEHNVEVIVMITNLVEKGRRKCDQYWPSDGSE-----------------EYGS 1817

  Fly   783 FV-------------FREFVL----------KDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTE 824
            |:             .|.|:|          |.:|.:|.:....|..|||..||......|.|..
Frog  1818 FLVTHKNTKVLAYYTVRTFILRNNKIKKGSQKGRHNERTVVQYHYTQWPDMGVPEYTLPVLTFVR 1882

  Fly   825 RVRAARNRTLLQEIEESLKQVRLMDADADADENGGLMRERKCAASNGATPEDETPVSTSVHQCIS 889
            :..|.                                   ||   ||
Frog  1883 KASAT-----------------------------------KC---NG------------------ 1891

  Fly   890 AANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCEC 954
              |.||:||||||:||||..|::|:.|..::....|.....::.:|.||..:||...||.|:.:.
Frog  1892 --NGPVVVHCSAGVGRTGTYIVLDSMLKQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYIFIHDA 1954

  Fly   955 ICAAYM 960
            :..|.:
Frog  1955 LVEAIL 1960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894
		PDZ_signaling	502..589	CDD:238492	24/140 (17%)
		Y_phosphatase	666..955	CDD:278528	97/321 (30%)
		PTPc	668..955	CDD:238006	96/319 (30%)
ptprz1	NP_001362251.1	alpha_CARP_receptor_like	45..298	CDD:239396
		fn3	313..395	CDD:365830
		PTP_DSP_cys	1690..1960	CDD:391942	105/375 (28%)
		R-PTP-Z-2	2043..2246	CDD:350507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910