DRSC/TRiP Functional Genomics Resources

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Protein Alignment mth and ADGRG1

DIOPT Version :10

Sequence 1:NP_728521.1 Gene:mth / 38058 FlyBaseID:FBgn0023000 Length:522 Species:Drosophila melanogaster
Sequence 2:XP_005256294.1 Gene:ADGRG1 / 9289 HGNCID:4512 Length:698 Species:Homo sapiens


Alignment Length:391 Identity:85/391 - (21%)
Similarity:149/391 - (38%) Gaps:120/391 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   181 TLRKRE----YCLQHLT-FADGNATSIRI-APHNCLIVPSITGQTVVMISSLICMVLTIAVYLFV 239
            |:|:..    :| .||| ||....:|:.: |.|...:  |:......::|:|.|:| |||.||  
Human   373 TVRRETQTSCFC-NHLTYFAVLMVSSVEVDAVHKHYL--SLLSYVGCVVSALACLV-TIAAYL-- 431

  Fly   240 KKLQNLHGKCFICYMVC-------LFMGYLFLLLDLWQISISF--------------CKPAGFLG 283
                     |....:.|       ....::.|||.::.:..||              |:.:....
Human   432 ---------CSRVPLPCRRKPRDYTIKVHMNLLLAVFLLDTSFLLSEPVALTGSEAGCRASAIFL 487

  Fly   284 YFFVMAAFFWLSVISLHLWNTFRGSSHKANRFLFEHRFLAYNTY-----------AWGMAVVLTG 337
            :|.::....|:.:...:|:           |.:.|    .:.||           .||..:.|..
Human   488 HFSLLTCLSWMGLEGYNLY-----------RLVVE----VFGTYVPGYLLKLSAMGWGFPIFLVT 537

  Fly   338 ITVLADNIVENQDWNP----------RVGHEGHCWIYTQAWSAMLYFYG----PMVFLIAFNITM 388
            :..|.|  |:|  :.|          .|.:...|||..   |.:.|...    .:|||  ||:.|
Human   538 LVALVD--VDN--YGPIILAVHRTPEGVIYPSMCWIRD---SLVSYITNLGLFSLVFL--FNMAM 593

  Fly   389 FILTAKRILGVKKDIQNFAHRQERKQKLNSDKQTYTFFLRLFIIMGLSWSLEIGSYFSQSNQTWA 453
            ......:||.::...|.::|              ....|.|.:::||.|:|   .:||.::.|:.
Human   594 LATMVVQILRLRPHTQKWSH--------------VLTLLGLSLVLGLPWAL---IFFSFASGTFQ 641

  Fly   454 NVFL-VADYLNWSQGIIIFILFVLKRSTWRL-LQERNHPKSTRSVISNRSMASRITVGTTPKNKA 516
            .|.| :...:...||.:|||.:      |.: ||.|..|    |.:.:.|.::|:.:.:...:.:
Human   642 LVVLYLFSIITSFQGFLIFIWY------WSMRLQARGGP----SPLKSNSDSARLPISSGSTSSS 696

  Fly   517 R 517
            |
Human   697 R 697

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthNP_728521.1 Methuselah_N 29..209 CDD:429053 11/33 (33%)
7tmB3_Methuselah-like 219..488 CDD:410632 67/316 (21%)
TM helix 2 247..269 CDD:410632 5/28 (18%)
TM helix 3 277..304 CDD:410632 3/26 (12%)
TM helix 4 321..341 CDD:410632 5/30 (17%)
TM helix 5 367..396 CDD:410632 8/32 (25%)
TM helix 6 418..445 CDD:410632 6/26 (23%)
TM helix 7 453..478 CDD:410632 7/25 (28%)
ADGRG1XP_005256294.1 PLL 34..167 CDD:436599
GAIN_A 178..225 CDD:436625
GPS 350..393 CDD:460350 8/20 (40%)
7tm_GPCRs 405..679 CDD:475119 71/338 (21%)
TM helix 1 408..432 CDD:320661 10/37 (27%)
TM helix 2 448..469 CDD:320661 5/20 (25%)
TM helix 3 481..503 CDD:320661 2/21 (10%)
TM helix 4 523..539 CDD:320661 3/15 (20%)
TM helix 5 572..595 CDD:320661 8/24 (33%)
TM helix 6 614..636 CDD:320661 8/24 (33%)
TM helix 7 642..667 CDD:320661 8/30 (27%)
Blue background indicates that the domain is not in the aligned region.

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