Protein Alignment mth and adgrg3

DIOPT Version :10

• Sequence 1: NP_728521.1
• Gene: mth / 38058
• FlyBaseID: FBgn0023000
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: XP_073763566.1
• Gene: adgrg3 / 799479
• ZFINID: ZDB-GENE-140106-110
• Length: 518
• Species: Danio rerio
• Alignment Length: 568
• Identity: 117/568 - (20%)
• Similarity: 192/568 - (33%)
• Gaps: 171/568 - (30%)

  Fly    25 DILECDYFDTVDISAAQKLQNGSYLFEGLLVPAILTGEYDFRILPDDSKQKVARHIRGCV----- 84
            |:|:|         ..||::|.|     .:.|.|.|..|..:.:  ||..|.....:|.|
Zfish    39 DVLQC---------MEQKMKNCS-----AIRPRIPTPNYFVKSI--DSLVKSLDTEKGYVINISD 87

  Fly    85 -----------------CKLKPCVRFCCPHDHIMDNGVCYDNMSDE-----ELAELDP------F 121
                             .|||.         :::|..:.....|.|     :|...||      .
Zfish    88 EALQRSRDGLENSSSEDVKLKV---------YLLDESLFKITSSSEIKEGNDLNGSDPVLLKQSV 143

  Fly   122 LNVTLDDGSV-------------SRRHFKNELIVQWDLPMPCDGMFYLDNREEQDKYTLFENGTF 173
            |.|.|....|             :....:|.:.|.|.|.....|.:..|..:     |..:||.|
Zfish   144 LGVWLGTTEVNNLSQPVQLKFRNTHNQTENGICVYWHLEKNGGGNWSTDGCK-----TNIDNGDF 203

  Fly   174 FRHFDRVTLRKREYC-LQHLTFADGNATSIRIAPHNCLIVPSITGQTVVMISSLICMV------- 230
                         .| ..||:|            ...||.|.|..::.::..:.|..|
Zfish   204 -------------VCSCNHLSF------------FAVLISPQIPEKSHIVHLNYISYVGSALSIA 243

  Fly   231 ---LTIAVYLFVKKLQNLHGKCF-ICYMVCLFMGYLFLLLDLW----QISISFCKPAGFLGYFFV 287
               |.|.::|..:|.|..|.... :....|||:.::..|..:|    ..|.|.|:..|.|.::.:
Zfish   244 FTSLVIVLFLCQRKKQCEHSLVIHVQLSSCLFLLHISFLCSVWFSGHSDSDSVCQTIGLLLHWCL 308

  Fly   288 MAAFFWLSVISLHLW-------NTFRGSSHKANRFLFEHRFLAYNTYAWGMAVV---LTGITVLA 342
            :|.|.|.::...||:       |.:      ..|::     |..:...||:..|   :.|:|.:.
Zfish   309 LATFTWTAIEGFHLYLLLVRVFNIY------IKRYM-----LKLSLMGWGVPTVTAMICGMTKVY 362

  Fly   343 DNIVENQDWNPRVGHEGHCWIYTQAWSAMLYF--YGPMVFLIAFNITMFILTAKRILGVKKDIQN 405
            .......|...... ...||:.|   :.::|.  .|.:..::.||:.|..:...::
Zfish   363 GKYTLYTDQENSTA-TSLCWVTT---NTVIYITVNGYLGLVMLFNMAMLAVVVVKM--------- 414

  Fly   406 FAHRQERKQKLNSDKQTYTF-----FLRLFIIMGLSWSLEIGSYFSQSNQTWANVFLVADYLNWS 465
               ||.|:|.:..|.|...:     .|.|..::|:.|.|.    ||...........|...||..
Zfish   415 ---RQLRQQNVQIDHQKRAWKDCVSLLGLCFVLGVPWGLA----FSTHGPLSLPALYVFTILNSF 472

  Fly   466 QGIIIFILFVLKRSTWRLLQERNHPKSTRSV--ISNRSMASRITVGTT 511
            ||:.|| |::|..:.....:::...|.|..|  :||...   :|..||
Zfish   473 QGVFIF-LWILTLTCKARKEKQTSSKGTIQVSYLSNEEY---VTSKTT 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mth	NP_728521.1	Methuselah_N	29..209	CDD:429053	41/226 (18%)
		7tmB3_Methuselah-like	219..488	CDD:410632	62/300 (21%)
		TM helix 2	247..269	CDD:410632	4/22 (18%)
		TM helix 3	277..304	CDD:410632	7/33 (21%)
		TM helix 4	321..341	CDD:410632	6/22 (27%)
		TM helix 5	367..396	CDD:410632	5/30 (17%)
		TM helix 6	418..445	CDD:410632	7/31 (23%)
		TM helix 7	453..478	CDD:410632	9/24 (38%)
adgrg3	XP_073763566.1	None