Protein Alignment mth and adgrg11

DIOPT Version :10

• Sequence 1: NP_728521.1
• Gene: mth / 38058
• FlyBaseID: FBgn0023000
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: XP_021329059.2
• Gene: adgrg11 / 563883
• ZFINID: ZDB-GENE-041210-320
• Length: 793
• Species: Danio rerio
• Alignment Length: 466
• Identity: 99/466 - (21%)
• Similarity: 165/466 - (35%)
• Gaps: 130/466 - (27%)

  Fly   104 GVCYDNMSDEELAE----LDPFLNVTLDDGSVSRRHFKNELIV-----QWDLPMPCD---GMFYL 156
            |:.....|:.|:.|    ..|...|.|.|.....:::.|.|||     |..|....:   |:|..
Zfish   346 GILKKIQSESEVTETAFIYSPATGVRLIDDPTVLKNYPNALIVPKEAAQQALNQSSNAFLGVFRF 410

  Fly   157 DNREE---------QDKYTLFENGTFFRHFDRVTLRKREYCLQHLTFA--------------DGN 198
            .|..:         .:.|.: |.||..::.....         :|:|.              |||
Zfish   411 PNMSKDANNSDVLNNEVYAI-EMGTKIKNLSNTI---------NLSFNMSQSTSGTPTCYSWDGN 465

  Fly   199 ATSIRIAPHNCLIVPSITGQTVVMISSLICMV--LTIAVYLFVK-----KLQNLHGKCFICYMVC 256
            .:........|        :|||..|.:.|..  ||....|...     :..:|....:|.|:.|
Zfish   466 GSKPDWTTEGC--------RTVVNGSGITCKCEHLTFFAVLMAPPDITLRESDLTALTYITYIGC 522

  Fly   257 ----------LFMGYLF--------------LLLDLWQISISF--------------CK-PAGFL 282
                      |||.:|.              |.|.|:.::::|              |: .|.||
Zfish   523 GLSMFFLGVGLFMHFLMRKAKATNSVHVLINLFLALFMLNVAFLTNEYVVQAQNSILCRVMAAFL 587

  Fly   283 GYFFVMAAFFWLSVISLHLWNTFRGSSHKANRFLFEHRFLAYNTYAWG-MAVVLTGITVLA---- 342
             ::.::::|.|.:|.:|||      ..........:|..|......|. .|.|::.|..|.
Zfish   588 -HYCLLSSFTWFAVEALHL------CLQMTKTATLKHYLLKITVAGWAPPAFVVSVIFSLGKYGE 645

  Fly   343 DNIVENQDWNPRVGHEGHCWIYTQAWSAMLYF--YGPMVFLIAFNITMFILTAKRILGVKKDIQN 405
            |||: .:..|..:     |||..   |.:.|.  .|...|:..|.:..||:..:.:..::....:
Zfish   646 DNIM-TESRNVTM-----CWIVD---STVHYVVNIGYYCFVFTFTLGTFIVVVRWLSMLRMSKWS 701

  Fly   406 FAHRQERKQKLNSDKQTYTFFLRLFIIMGLSWSLEIGSYFSQSNQTWANVFLVADYLNWSQGIII 470
            ...:.:|.....||..|   .|.|..::||:|.:   |:||.......:.::.. .||..||..:
Zfish   702 KDGKVKRSGTATSDIST---MLGLCCLLGLTWGI---SFFSYGALRMPSYYIFT-ILNSLQGFFL 759

  Fly   471 FILFVLKRSTW 481
            |: :.||.||:
Zfish   760 FV-YYLKTSTF 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mth	NP_728521.1	Methuselah_N	29..209	CDD:429053	26/139 (19%)
		7tmB3_Methuselah-like	219..488	CDD:410632	72/316 (23%)
		TM helix 2	247..269	CDD:410632	9/45 (20%)
		TM helix 3	277..304	CDD:410632	9/27 (33%)
		TM helix 4	321..341	CDD:410632	5/20 (25%)
		TM helix 5	367..396	CDD:410632	7/30 (23%)
		TM helix 6	418..445	CDD:410632	9/26 (35%)
		TM helix 7	453..478	CDD:410632	6/24 (25%)
adgrg11	XP_021329059.2	None