DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mth and Adgre4

DIOPT Version :10

Sequence 1:NP_728521.1 Gene:mth / 38058 FlyBaseID:FBgn0023000 Length:522 Species:Drosophila melanogaster
Sequence 2:NP_001007559.1 Gene:Adgre4 / 450235 RGDID:1359641 Length:683 Species:Rattus norvegicus


Alignment Length:576 Identity:118/576 - (20%)
Similarity:199/576 - (34%) Gaps:207/576 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 KQKVARHIRGCVCKLKPCVRFCC---PHDH---------------IMDNGVCYDNMSDEELAELD 119
            :.|:..:|..||.|. |.:.:..   ..||               ...:||.||..|.|::|:  
  Rat    93 RNKIGTYICSCVVKY-PIINWVAAIFDIDHPDCYVNKSNEIGSKAACTSGVLYDCNSKEDVAK-- 154

  Fly   120 PFLNVTLDDGSVSRRHFKNELIVQWDLPMP-----------------------------CDGMFY 155
             ...|.|.:   :.||..||   ..|.|:.                             |..:  
  Rat   155 -GATVYLQN---TERHILNE---NSDTPIKSSTRDIVYETNKCKKTTILEAGNNTMKINCTSV-- 210

  Fly   156 LDNREEQDKYTL----------FENGTFFRH---FDRVTL------------------------- 182
            |...:.:|:.|:          ..||:|||:   |..|.|                         
  Rat   211 LKENKNRDETTVAFIAYKSLGNLLNGSFFRNKEGFQEVKLNSHIVSGAIRSEIKPVLSEPVILTL 275

  Fly   183 --------RKREYCLQHLTFADGNATSIRIAPH----------NCL-----------------IV 212
                    |....|:......:|.:.|.:...|          .|.                 ::
  Rat   276 QNTQPIDSRAEHLCVYWEGSEEGGSWSTKGCSHVYTNKSYTICKCFHLSSFAVLVGLSNEENAVL 340

  Fly   213 PSITGQTVVMIS-SLICMVLTIAVYLFVKKLQNLHGKCFICYMVCLFMGYLFLLLDLWQISISFC 276
            .:::..|.|.:| ||:|:.|....:|..:.:||......:...:|||:..|..|     |.|:..
  Rat   341 SALSVITYVGLSLSLLCLFLAAITFLLCRPIQNTSTTLHLQLSICLFLADLLFL-----IGINRT 400

  Fly   277 KP-------AGFLGYFFVMAAFFWLSVISLHLWNTFRGSSHKANRFLFEHRFLAYNTY--AWGMA 332
            ||       ||.|.|.: :|:|.|:.:..|||:.|.|  :.|...:....||.....|  .:|..
  Rat   401 KPKVLCSIIAGMLHYLY-LASFMWMFLEGLHLFLTVR--NLKVANYSHSGRFKKRLMYPVGYGFP 462

  Fly   333 VVLTGITVLADNIVENQDWNPRVGHE-----GHCWIYTQ---AWSAMLYFYGPMVFLIAFNI--- 386
            .::..::.:|             ||:     .|||:...   .||    |.||:..:|..|:   
  Rat   463 ALIVAVSAIA-------------GHKNYGTYNHCWLSLHRGFIWS----FLGPVAAIILINLVFY 510

  Fly   387 --TMFILTAKRILGVKKDIQNFAHRQERKQKLNSDKQTYTFFLRLFIIMGLSWSLEIGSYFSQSN 449
              .::||.:| :..:.|::...   |:.|      ..|:...::|| ::|.||.:.:..:|    
  Rat   511 FQVLWILRSK-LSSLNKEVSTL---QDTK------IMTFKAIVQLF-VLGCSWGIGLFIFF---- 560

  Fly   450 QTWANVFLVADYL----NWSQGIIIFILFVLKRSTWRL--------LQERNHPKST 493
            :....|.|:..||    |..||::||::..|.....|:        ||.....:||
  Rat   561 EVGKTVRLIFAYLFTIINVLQGVLIFLVHCLLNRQVRMEYKKWFHRLQRETESEST 616

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthNP_728521.1 Methuselah_N 29..209 CDD:429053 40/238 (17%)
7tmB3_Methuselah-like 219..488 CDD:410632 75/303 (25%)
TM helix 2 247..269 CDD:410632 5/21 (24%)
TM helix 3 277..304 CDD:410632 12/33 (36%)
TM helix 4 321..341 CDD:410632 3/21 (14%)
TM helix 5 367..396 CDD:410632 10/33 (30%)
TM helix 6 418..445 CDD:410632 6/26 (23%)
TM helix 7 453..478 CDD:410632 10/28 (36%)
Adgre4NP_001007559.1 EGF_CA 75..>103 CDD:214542 2/9 (22%)
GAIN <209..261 CDD:465137 11/53 (21%)
GPS 287..329 CDD:460350 5/41 (12%)
7tm_GPCRs 342..606 CDD:475119 73/303 (24%)
TM helix 1 343..367 CDD:410628 7/23 (30%)
TM helix 2 376..397 CDD:410628 6/25 (24%)
TM helix 3 407..429 CDD:410628 7/22 (32%)
TM helix 4 453..469 CDD:410628 2/15 (13%)
TM helix 5 488..511 CDD:410628 7/26 (27%)
TM helix 6 538..563 CDD:410628 7/29 (24%)
TM helix 7 568..593 CDD:410628 9/24 (38%)

Return to query results.
Submit another query.