Protein Alignment mth and mthl5

DIOPT Version :10

• Sequence 1: NP_728521.1
• Gene: mth / 38058
• FlyBaseID: FBgn0023000
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_001287291.1
• Gene: mthl5 / 41438
• FlyBaseID: FBgn0037960
• Length: 497
• Species: Drosophila melanogaster
• Alignment Length: 461
• Identity: 94/461 - (20%)
• Similarity: 169/461 - (36%)
• Gaps: 101/461 - (21%)

  Fly    91 VRFCCPHDHIMDNGVCYDNMSDEELAELDPFLNVTLDDGSVSRRHFKNELIVQWDLPMPCDGM-- 153
            |..||....|..:..|      :::.|.|.|..:....|....|..|.:.::  .:| .|..|
  Fly    63 VNKCCEKFEIHVDHEC------QQVNETDYFQPMFTSYGGEQNRPVKFKFVI--GIP-NCGSMQM 118

  Fly   154 ----FYLDNREEQDKYTLFENGTFFRHFDRVTLRKRE---------------------------Y 187
                .|..:   .||..|.::|. .||:........|                           |
  Fly   119 WPIYHYAGS---SDKLVLLDDGR-LRHYTNAENEAEERHGIQSDYEEDIAGSLEPLYHDYDKGLY 179

  Fly   188 CLQHLTFADGNAT-----------SIRIAPHNCL----IVPSITGQTVVMISSLICMVLTIAVYL 237
            |:...|.:.|...           .|:.:..|.|    :.|...|     ||.:|.:|:.|..::
  Fly   180 CIDKATSSTGEENVLFANICLARKEIKWSDSNFLLRKILNPIFHG-----ISLVILLVIAIIYFI 239

  Fly   238 FVKKLQNLHGKCFICYMVCLFMGYLFLLLDLWQI------SISFCKPAGFLGYFFVMAAFFWLSV 296
            .....::|.|.......:||.:..   ..||.:|      .:||. .|..:..|.::||||||:.
  Fly   240 LPTLSRDLVGNIVTTIAMCLMVSQ---AADLVRIFTELTSHVSFI-VADIILCFSLLAAFFWLNS 300

  Fly   297 ISLHLWNTFRGSSHKANRFLFEHRFLAYNTYAWGMAVVLTGITVLADNIVENQDWNPR--VGHEG 359
            ...::|.||| |.:...|.....::..|:.||||....:..:.|.|...::.:.:...  ||.:
  Fly   301 FGFYIWKTFR-SRNVFLRVTDGRKYCYYSAYAWGCTATMAALAVFAHFFLDAESYKQEHMVGEQ- 363

  Fly   360 HCWIYTQAWSAMLYFYGPMVFLIAFNITMFILTAKRILGVKKDIQNFAHRQERKQKLNSDKQTYT 424
                .|..|..:..|:.|:...|..|| .|.:|.::::..:......||:.         |..:.
  Fly   364 ----ETIGWLGICIFFAPIACTILVNI-FFYVTTRKLINRRTVYGRIAHKL---------KANFI 414

  Fly   425 FFLRLFIIMGLSWSLEIGSYFSQSNQTWANVFLVADYLNWSQGIIIFILFVLKRSTWRLLQER-- 487
            .|..:.::|.::|...|.|:.......:|::.:.|    ....::::|..:.:|....||::.
  Fly   415 MFSLMLLVMSIAWLFLIMSWLQMEGLLYAHIVVNA----LQTPLLLYICVLRQRHVTFLLKKTCC 475

  Fly   488 -NHPKS 492
             |.|.|
  Fly   476 YNEPPS 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mth	NP_728521.1	Methuselah_N	29..209	CDD:429053	27/161 (17%)
		7tmB3_Methuselah-like	219..488	CDD:410632	60/279 (22%)
		TM helix 2	247..269	CDD:410632	4/21 (19%)
		TM helix 3	277..304	CDD:410632	9/26 (35%)
		TM helix 4	321..341	CDD:410632	5/19 (26%)
		TM helix 5	367..396	CDD:410632	8/28 (29%)
		TM helix 6	418..445	CDD:410632	6/26 (23%)
		TM helix 7	453..478	CDD:410632	3/24 (13%)
mthl5	NP_001287291.1	7tmB3_Methuselah-like	215..474	CDD:410632	62/287 (22%)
		TM helix 1	215..239	CDD:410632	7/28 (25%)
		TM helix 2	249..271	CDD:410632	5/24 (21%)
		TM helix 3	281..308	CDD:410632	9/27 (33%)
		TM helix 4	324..344	CDD:410632	5/19 (26%)
		TM helix 5	371..396	CDD:410632	7/25 (28%)
		TM helix 6	409..435	CDD:410632	6/34 (18%)
		TM helix 7	438..463	CDD:410632	3/28 (11%)