Protein Alignment mth and adgrl4

DIOPT Version :10

• Sequence 1: NP_728521.1
• Gene: mth / 38058
• FlyBaseID: FBgn0023000
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_998532.3
• Gene: adgrl4 / 406676
• ZFINID: ZDB-GENE-040426-2689
• Length: 738
• Species: Danio rerio
• Alignment Length: 460
• Identity: 113/460 - (24%)
• Similarity: 177/460 - (38%)
• Gaps: 133/460 - (28%)

  Fly    99 HIMDNG------VCYDNMSDEELAELDPFLNVTLDDGSV---SRRHFKNELIV-----------Q 143
            |..:||      :.|.::.|         |....||..|   ||.....|:.|           |
Zfish   337 HANNNGSTSVVFLIYHSIGD---------LLKPADDPGVADYSRYAAAGEITVNSPVIAAAISNQ 392

  Fly   144 WDLPMPCDGMFYLDNREEQD------KYTLFE-NGTFFRHFD-------RVTLRKREYCLQHLT- 193
            ..||:. |..|.|.:.:|.|      |...:| :.:...|:.       ||..........|||
Zfish   393 KTLPLN-DVTFTLKHTQEIDPARDETKCAFWEYSPSMMGHWSLDGCIRTRVNTTHTSCSCNHLTH 456

  Fly   194 FA--DGNATSIRIAPHNCLIVPSITGQTVVMISSLICMVLTIAVYLFVKKLQN----LHGKCFIC 252
            ||  ..:|.:..:|.:|.|...:..|    |:.||||:.:.|..:.|.:.:||    :| |...|
Zfish   457 FAILMSSARANLLAHYNVLTRITQLG----MVISLICLSMCIFTFWFFRDIQNTRTTIH-KNLCC 516

  Fly   253 YMVCLFMGYLFLLLDL------WQISISFCK-PAGFLGYFFVMAAFFWLSVISLHLWNTFRGSSH 310
               .|||.....|:.:      |     ||. .||.|.||| :|||.|:.:..:||:....|
Zfish   517 ---SLFMAQFIFLIGINKSAHKW-----FCSLIAGLLHYFF-LAAFAWMCIEGIHLYLIVVG--- 569

  Fly   311 KANRFLFEHRFLAYNTYAWGM---AVVLTGITVLADNIVENQDWNPRVGHEGHCWIYTQ---AWS 369
                .::...||..|.||:|.   |||:.....|....         .|....||:.|:   .||
Zfish   570 ----VIYNKGFLHRNFYAFGYGSPAVVVAISATLGYKY---------YGTSSVCWLSTENNFIWS 621

  Fly   370 AMLYFYGPMVFLIAFNITMFILTAKRILGVKKDIQNFAHRQERKQKLN---SDKQTYTFFLRLFI 431
                |.||.:.:|..|:..|.:...::         :.|...:|.:::   :.:......:.|..
Zfish   622 ----FIGPAILIILVNLLAFAVIIYKV---------YRHTAVKKPEISHYENIRSCARGAIALLF 673

  Fly   432 IMGLSWSLEIGSYFSQSNQ-----TWANVFLVADYLNWSQGIIIFI-LFVLKRSTWRLLQE---- 486
            ::|::|:..:.....::..     |:||||         ||:.||| |.||.|   |:.:|
Zfish   674 VLGVTWAFGVMYILYETTLTAYLFTFANVF---------QGMFIFIFLCVLSR---RIQEEYYRL 726

  Fly   487 -RNHP 490
             :|.|
Zfish   727 FKNMP 731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mth	NP_728521.1	Methuselah_N	29..209	CDD:429053	33/146 (23%)
		7tmB3_Methuselah-like	219..488	CDD:410632	75/299 (25%)
		TM helix 2	247..269	CDD:410632	6/27 (22%)
		TM helix 3	277..304	CDD:410632	12/27 (44%)
		TM helix 4	321..341	CDD:410632	9/22 (41%)
		TM helix 5	367..396	CDD:410632	8/28 (29%)
		TM helix 6	418..445	CDD:410632	3/26 (12%)
		TM helix 7	453..478	CDD:410632	12/25 (48%)
adgrl4	NP_998532.3	None