Protein Alignment mth and mthl2

DIOPT Version :10

• Sequence 1: NP_728521.1
• Gene: mth / 38058
• FlyBaseID: FBgn0023000
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_788462.2
• Gene: mthl2 / 38636
• FlyBaseID: FBgn0035623
• Length: 518
• Species: Drosophila melanogaster
• Alignment Length: 508
• Identity: 316/508 - (62%)
• Similarity: 384/508 - (75%)
• Gaps: 8/508 - (1%)

  Fly     5 LVLRISTVILVVLVIQKSYADILECDYFDTVDISAAQKLQNGSYLFEGLLVPAILTGEYDFRILP 69
            ::|..|.:|..:|.:|.|.|:|.:|.::||||||..|:|.|||||:||||:||.||.:|:|::|.
  Fly     7 MLLSASILIYFLLNLQSSSAEIADCSFYDTVDISEGQRLSNGSYLYEGLLIPAHLTAKYEFKLLA 71

  Fly    70 DDSKQKVARHIRGCVCKLKPCVRFCCPHDHIMDNGVCYDNMSDEELAELDPFLNVTLDDGSVSRR 134
            :..|::|..|:|||||||:.|||||||||||||.|.||.||:.||...|||.||||||||||.:|
  Fly    72 NGDKEQVPSHVRGCVCKLRTCVRFCCPHDHIMDMGECYANMTTEENELLDPMLNVTLDDGSVVQR 136

  Fly   135 HFKNELIVQWDLPMPCDGMFYLDNREEQDKYTLFENGTFFRHFDRVTLRKREYCLQHLTFADGNA 199
            |:|.||:||||||.|||.|||||||:..|:|||||||...||:|:|.|.|.||||||.||.:||.
  Fly   137 HYKKELMVQWDLPKPCDDMFYLDNRDIMDEYTLFENGRLLRHYDQVYLDKSEYCLQHRTFGEGNN 201

  Fly   200 TSIRIAPHNCLIVPSITGQTVVMISSLICMVLTIAVYLFVKKLQNLHGKCFICYMVCLFMGYLFL 264
            .||||.||||||:||.||||||||:||||:||||||||.||||.||.||||||||:|||.|||||
  Fly   202 NSIRIIPHNCLILPSRTGQTVVMITSLICLVLTIAVYLCVKKLMNLEGKCFICYMMCLFFGYLFL 266

  Fly   265 LLDLWQISISFCKPAGFLGYFFVMAAFFWLSVISLHLWNTFRGSSHKANRFLFEHRFLAYNTYAW 329
            |||||::|:.|||.|||||||||||||||||:||.|.|..........| ...|..||.|:.:||
  Fly   267 LLDLWELSLDFCKAAGFLGYFFVMAAFFWLSIISRHYWKCLTNPCASMN-IRSERAFLLYSCFAW 330

  Fly   330 GMAVVLTGITVLADNIVENQDWNPRVGHEGHCWIYTQAWSAMLYFYGPMVFLIAFNITMFILTAK 394
            .|.:.|||:|.||||:|.|::|.||||.||||||||::||||:|||||||.||.||||||:||||
  Fly   331 AMPLALTGVTYLADNVVNNEEWQPRVGDEGHCWIYTKSWSAMVYFYGPMVLLILFNITMFVLTAK 395

  Fly   395 RILGVKKDIQNFAHRQERKQKLNSDKQTYTFFLRLFIIMGLSWSLEIGSYFSQSNQTWANVFLVA 459
            .|:..|:.::..|..:.|.||||||||.||.||.||.:||:|||.||.||..|..:.|.|:||||
  Fly   396 HIIDSKRTLRKIARNEGRIQKLNSDKQNYTQFLLLFTVMGMSWSFEIFSYLVQREKLWVNIFLVA 460

  Fly   460 DYLNWSQGIIIFILFVLKRSTWRLLQERNHPK-------STRSVISNRSMASR 505
            ||.|||||:|||:||:|:|.|..|.:::..||       :|:|.|.:.|...|
  Fly   461 DYFNWSQGVIIFVLFILRRKTLVLFKKQIFPKQRAFSRSATQSTIESISQTKR 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mth	NP_728521.1	Methuselah_N	29..209	CDD:429053	119/179 (66%)
		7tmB3_Methuselah-like	219..488	CDD:410632	173/268 (65%)
		TM helix 2	247..269	CDD:410632	19/21 (90%)
		TM helix 3	277..304	CDD:410632	22/26 (85%)
		TM helix 4	321..341	CDD:410632	10/19 (53%)
		TM helix 5	367..396	CDD:410632	23/28 (82%)
		TM helix 6	418..445	CDD:410632	18/26 (69%)
		TM helix 7	453..478	CDD:410632	18/24 (75%)
mthl2	NP_788462.2	Methuselah_N	31..211	CDD:429053	119/179 (66%)
		7tmB3_Methuselah-like	215..489	CDD:410632	178/274 (65%)
		TM helix 1	215..240	CDD:410632	21/24 (88%)
		TM helix 2	249..269	CDD:410632	17/19 (89%)
		TM helix 3	279..306	CDD:410632	22/26 (85%)
		TM helix 4	322..342	CDD:410632	10/19 (53%)
		TM helix 5	367..397	CDD:410632	23/29 (79%)
		TM helix 6	419..446	CDD:410632	18/26 (69%)
		TM helix 7	454..479	CDD:410632	18/24 (75%)