Protein Alignment mth and mthl9

DIOPT Version :10

• Sequence 1: NP_728521.1
• Gene: mth / 38058
• FlyBaseID: FBgn0023000
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_612029.1
• Gene: mthl9 / 38056
• FlyBaseID: FBgn0035131
• Length: 513
• Species: Drosophila melanogaster
• Alignment Length: 530
• Identity: 141/530 - (26%)
• Similarity: 240/530 - (45%)
• Gaps: 80/530 - (15%)

  Fly     9 ISTVILVVLVIQKSYADILE-------CDYFDTVDISAAQKLQNGSYLFEGLLVPAILTGEYDFR 66
            :|.:|:::::.....|..:|       |.|..||:|:...::::|||.:.|::||..|..||.|:
  Fly     2 VSPLIILLIIWLSVGAKSVEIASINHPCAYAHTVNITDGLRMKDGSYSYAGVVVPPHLMAEYSFK 66

  Fly    67 ILPDDSKQKVARHIRGCVCKLKPCVRFCCPHDHIMD----NGVCYDNMSDEELAELDPFLNVTLD 127
            :: |..:.:..:|:|||||.||||:.||||.:.:.|    |......:.:....|| .:.|.|:|
  Fly    67 VI-DGVEYRAKKHLRGCVCLLKPCISFCCPENLVFDAKHWNCTMPHQVRESTHVEL-TYANRTVD 129

  Fly   128 DGSVSRRHFKNELIVQWDLPMPCDGMFYLDNREEQDKYTLFENGTFFRHFDRVTLRKREYCLQHL 192
            ...:     ::..:|:.:|  .|...|.....:...::.||||||..|  |.......|||...|
  Fly   130 QVRI-----RDRFVVRTEL--GCRNKFVDKKHDNFWQWDLFENGTLRR--DNRLWSTDEYCFSPL 185

  Fly   193 TFADGNATSIRIAPHNCLIVPSITGQTVVMISSLICMVLTIAVYLFVKKL--------QNLHGKC 249
               :.|.....:.|.||....  ||..|.:.:  ||.::.|.:.:|:..|        ::.:|:.
  Fly   186 ---EHNPEQWELTPLNCERFQ--TGYRVWIYA--ICSIIAIIINIFILSLLGSVRDARKSHYGQL 243

  Fly   250 FICYMVCLFMGYLFL----LLDLWQISISFCKPAGFLGYFFVMAAFFWLSVISLHLWNTFRGSSH 310
            .|.|::.:.:||..|    |.:..::|...|:..|||.||.:|.:|.:|::.||.....|:   .
  Fly   244 IIYYLLSMIVGYSLLVYLALKNPMKLSHVACRNIGFLAYFCIMLSFVFLAICSLDFLLKFK---Q 305

  Fly   311 KANRFLFEHRFLAYNTYAWGMAVVLTGITVLADNIVENQDWNPRVGHEGHCWIYTQAWSAMLYFY 375
            ||.|.......||....|   .:.|..:..||.:....:.:.|.:| |.:||...:.|..::|:|
  Fly   306 KAVRSSVRRLSLALAVLA---VIGLRFLVSLAQDSKLPKHFKPGMG-EDYCWFDVRTWGILIYYY 366

  Fly   376 GPMVFLIAFNITMFILTAKRILGVKKDIQNFAHRQERKQKLNSDKQTYTFFLRLFII-MGLSWSL 439
            ||:..|:.|:|...:.....|..:..|.|.....|.:..|      |:.:....:|: :...|..
  Fly   367 GPIALLLIFSIVCCLKAYFSIYELPPDTQYILGTQLKIVK------THFYAFSAYIVGVFAVWIR 425

  Fly   440 EIGSYFSQSNQTWANV---FLVADYLNWSQGIII-------FILFVLK----RSTWRLLQERNHP 490
            ||..|.      .|.|   |.:.|:  || ||.|       |||.:.|    :|.|.:..|.:
  Fly   426 EIVVYI------MARVREHFFIIDF--WS-GICILGLAIAGFILLLGKNLHVKSWWAINVESS-- 479

  Fly   491 KSTRSVISNR 500
            ::..|:|:.|
  Fly   480 QTDLSIINAR 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mth	NP_728521.1	Methuselah_N	29..209	CDD:429053	55/183 (30%)
		7tmB3_Methuselah-like	219..488	CDD:410632	75/295 (25%)
		TM helix 2	247..269	CDD:410632	7/25 (28%)
		TM helix 3	277..304	CDD:410632	10/26 (38%)
		TM helix 4	321..341	CDD:410632	4/19 (21%)
		TM helix 5	367..396	CDD:410632	8/28 (29%)
		TM helix 6	418..445	CDD:410632	5/27 (19%)
		TM helix 7	453..478	CDD:410632	13/38 (34%)
mthl9	NP_612029.1	Methuselah_N	29..199	CDD:429053	55/183 (30%)
		7tmB3_Methuselah-like	232..473	CDD:410632	67/262 (26%)
		TM helix 2	241..263	CDD:410632	6/21 (29%)
		TM helix 3	275..302	CDD:410632	10/26 (38%)
		TM helix 4	314..334	CDD:410632	4/22 (18%)
		TM helix 5	358..387	CDD:410632	8/28 (29%)
		TM helix 6	404..431	CDD:410632	6/32 (19%)
		TM helix 7	440..465	CDD:410632	9/27 (33%)