Protein Alignment mth and mthl3

DIOPT Version :10

• Sequence 1: NP_728521.1
• Gene: mth / 38058
• FlyBaseID: FBgn0023000
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_663308.1
• Gene: mthl3 / 36961
• FlyBaseID: FBgn0028956
• Length: 511
• Species: Drosophila melanogaster
• Alignment Length: 481
• Identity: 287/481 - (59%)
• Similarity: 367/481 - (76%)
• Gaps: 6/481 - (1%)

  Fly    10 STVILVVLVIQKSYADILECDYFDTVDISAAQKLQNGSYLFEGLLVPAILTGEYDFRILPDDSKQ 74
            |....::|::|.|.|:|..||:|||||||.|.:..|||||:||||:||.||.|||:::|.||||:
  Fly     7 SFTAFLLLLLQNSNAEIPGCDFFDTVDISKAPRFSNGSYLYEGLLIPAHLTAEYDYKLLADDSKE 71

  Fly    75 KVARHIRGCVCKLKPCVRFCCPHDHIMDNGVCYDNMSDEELAELDPFLNVTLDDGSVSRRHFKNE 139
            |||.|:|||.|.|:||:|||||....|....||.:||::||.:.|||:||||.||||.|||||.:
  Fly    72 KVASHVRGCACHLRPCIRFCCPQYQKMQKSKCYGDMSEDELNKHDPFVNVTLSDGSVVRRHFKED 136

  Fly   140 LIVQWDLPMP-CDGMFYLDNREEQDKYTLFENGTFFRHFDRVTLRKREYCLQHLTFADGNATSIR 203
            ||||.||..| |..|::|::....:::||||||:..||:|:|.|.|||||:|||:|.|   .|||
  Fly   137 LIVQSDLAKPGCPRMYFLNHELPGNEFTLFENGSLLRHWDKVELSKREYCVQHLSFKD---DSIR 198

  Fly   204 IAPHNCLIVP--SITGQTVVMISSLICMVLTIAVYLFVKKLQNLHGKCFICYMVCLFMGYLFLLL 266
            ||||.|.:..  |.|.:||.::.||||::|||:|||:|:||:||||||||||:..||:||.||:|
  Fly   199 IAPHFCPLSSEHSRTWKTVAIVISLICIILTISVYLYVEKLRNLHGKCFICYLASLFLGYFFLVL 263

  Fly   267 DLWQISISFCKPAGFLGYFFVMAAFFWLSVISLHLWNTFRGSSHKANRFLFEHRFLAYNTYAWGM 331
            ::|:.|..||..|||||||.|:|||||||||||.|||:|.|:|...||||.::|||:||.|||||
  Fly   264 NVWKYSSGFCVTAGFLGYFSVIAAFFWLSVISLTLWNSFSGNSSWLNRFLPQNRFLSYNLYAWGM 328

  Fly   332 AVVLTGITVLADNIVENQDWNPRVGHEGHCWIYTQAWSAMLYFYGPMVFLIAFNITMFILTAKRI 396
            |::||.||.:||.:|:|:...||||...:|||||...:.|:||||||:.:|.||||||:|||.||
  Fly   329 ALLLTAITYIADQVVKNEKLRPRVGVGKNCWIYTGDMTVMIYFYGPMLLIIVFNITMFVLTAFRI 393

  Fly   397 LGVKKDIQNFAHRQERKQKLNSDKQTYTFFLRLFIIMGLSWSLEIGSYFSQSNQTWANVFLVADY 461
            :.|||:.|||..:|:...:||||||||..||||||||||||||||.|:....||.||..|:||||
  Fly   394 MKVKKEAQNFTQQQKTTNRLNSDKQTYALFLRLFIIMGLSWSLEIISFLLSKNQAWAKAFMVADY 458

  Fly   462 LNWSQGIIIFILFVLKRSTWRLLQER 487
            .|||||.:||:||||:.||.:||:||
  Fly   459 FNWSQGTVIFLLFVLRPSTLKLLKER 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mth	NP_728521.1	Methuselah_N	29..209	CDD:429053	108/180 (60%)
		7tmB3_Methuselah-like	219..488	CDD:410632	170/269 (63%)
		TM helix 2	247..269	CDD:410632	14/21 (67%)
		TM helix 3	277..304	CDD:410632	21/26 (81%)
		TM helix 4	321..341	CDD:410632	14/19 (74%)
		TM helix 5	367..396	CDD:410632	17/28 (61%)
		TM helix 6	418..445	CDD:410632	23/26 (88%)
		TM helix 7	453..478	CDD:410632	17/24 (71%)
mthl3	NP_663308.1	Methuselah_N	26..204	CDD:429053	108/180 (60%)
		7tmB3_Methuselah-like	208..486	CDD:410632	172/277 (62%)
		TM helix 1	210..235	CDD:410632	13/24 (54%)
		TM helix 2	244..266	CDD:410632	14/21 (67%)
		TM helix 3	274..301	CDD:410632	21/26 (81%)
		TM helix 4	318..338	CDD:410632	14/19 (74%)
		TM helix 5	364..393	CDD:410632	17/28 (61%)
		TM helix 6	415..442	CDD:410632	23/26 (88%)
		TM helix 7	450..475	CDD:410632	17/24 (71%)