Protein Alignment mth and mthl1

DIOPT Version :10

• Sequence 1: NP_728521.1
• Gene: mth / 38058
• FlyBaseID: FBgn0023000
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_573140.1
• Gene: mthl1 / 32637
• FlyBaseID: FBgn0030766
• Length: 676
• Species: Drosophila melanogaster
• Alignment Length: 404
• Identity: 100/404 - (24%)
• Similarity: 171/404 - (42%)
• Gaps: 87/404 - (21%)

  Fly   186 EYCLQHLTFADGN----------ATSIRIAPHNCLI---VPSITGQTV--------VMISSLICM 229
            :|||:| |..:|.          :::.....|:..|   :....||.:        :::|.:...
  Fly   281 QYCLEH-TQREGEVKIIACQHLFSSAAGAGIHDGSIGGTIEQANGQNLQKAVLTGGILVSIVFLS 344

  Fly   230 VLTIAVYLFVKKLQNLHGKCFICYMVCLFMGYLFLLLDLWQISISF------CKPAGFLGYFFVM 288
            ...:|.:|.......||.:|.|||:.||..|.:.|.::  ::|.|.      |........||.:
  Fly   345 ATLVAGFLLPAVHHALHWRCQICYVTCLLFGKILLAIE--ELSSSLQPGSAACHTLAITMQFFFL 407

  Fly   289 AAFFWLSVISLHLWNTFRG---SSHKANRFLFEHRFLAYNTYAWGMAVVLTGITVLADNIVENQD 350
            ||||||:.:..::|.|||.   ||.:.|:... .|:| |:.||||..:::|.:....|.:.|...
  Fly   408 AAFFWLNTMCFNIWWTFRDFRPSSLERNQEAL-RRYL-YSLYAWGGPLLITFVAACVDQLPETTL 470

  Fly   351 WNPRVGHEGHCWIYTQAWSAMLYFYGPMVFLIAFNITMFILTAKRI---LGVKKDIQNFAHRQER 412
            ..|..| :.:||...:..|...|||||:..|:..||.:|:.|..::   |..:.|:
  Fly   471 LRPGFG-QLYCWFDNRNLSIFAYFYGPIGLLLCANIALFVSTTHQLTCGLWKRDDV--------- 525

  Fly   413 KQKLNSDKQTY-TFFLRLFIIMGLSWSLEIGSYFSQSNQTWANVFLVADYLNWSQGIIIFILFVL 476
              |.:|:|... ...|:|.::||::|..:|.|:......   .|:...|.:|..||:.|||:...
  Fly   526 --KSSSEKSALGRVCLKLVVVMGVTWIADILSWLVGGPH---GVWFFTDLINALQGVFIFIVVGC 585

  Fly   477 KRSTW----RLLQER------------NHPKSTRSV--------ISNRSMASRITVGTT----PK 513
            :...|    |:...|            .|..|::.:        |:..:..:..|..||    |.
  Fly   586 QPQVWTACRRIFCPRLRHDITNTTNGVQHSSSSQGLPSMAGGTEITQNTTTTTTTTNTTATHMPS 650

  Fly   514 NKARN-----SPLA 522
            |.|.:     :|:|
  Fly   651 NPAEDEVPEKAPIA 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mth	NP_728521.1	Methuselah_N	29..209	CDD:429053	7/32 (22%)
		7tmB3_Methuselah-like	219..488	CDD:410632	79/305 (26%)
		TM helix 2	247..269	CDD:410632	8/21 (38%)
		TM helix 3	277..304	CDD:410632	9/26 (35%)
		TM helix 4	321..341	CDD:410632	7/19 (37%)
		TM helix 5	367..396	CDD:410632	11/28 (39%)
		TM helix 6	418..445	CDD:410632	9/27 (33%)
		TM helix 7	453..478	CDD:410632	8/24 (33%)
mthl1	NP_573140.1	7tmB3_Methuselah-like	326..598	CDD:410632	78/290 (27%)
		TM helix 1	327..352	CDD:410632	2/24 (8%)
		TM helix 2	362..384	CDD:410632	8/23 (35%)
		TM helix 3	396..423	CDD:410632	9/26 (35%)
		TM helix 4	441..461	CDD:410632	8/20 (40%)
		TM helix 5	485..515	CDD:410632	11/29 (38%)
		TM helix 6	530..557	CDD:410632	8/26 (31%)
		TM helix 7	562..587	CDD:410632	8/27 (30%)