Protein Alignment mth and Adgrg2

DIOPT Version :10

• Sequence 1: NP_728521.1
• Gene: mth / 38058
• FlyBaseID: FBgn0023000
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_852031.1
• Gene: Adgrg2 / 266735
• RGDID: 628618
• Length: 1013
• Species: Rattus norvegicus
• Alignment Length: 430
• Identity: 98/430 - (22%)
• Similarity: 162/430 - (37%)
• Gaps: 136/430 - (31%)

  Fly   109 NMSDEELAELDPFLNVTLDDGSVSRRHF---KNELIVQ---WDL-------PMPCDGMFYLDNRE 160
            ||:.:.|..     |||     |:.:|.   :::|.|:   |||       ....||....:.|.
  Rat   538 NMTIKNLTR-----NVT-----VALKHINPSQDDLTVKCVFWDLNRNGGRGGWSSDGCSVKEKRM 592

  Fly   161 EQDKYTLFENGTFFRHFDRVTLRKREYCLQHLT----FADGNATSIRIAPHNCLIVPSIT----G 217
            .:...|                     | .|||    ..|.:.||  :.|...:.:..||    |
  Rat   593 NETICT---------------------C-SHLTSFGILLDLSRTS--LPPSQMMALTFITYIGCG 633

  Fly   218 QTVVMISSLICMVLTIAVYLFVKKL-QNLHGKCFICYMVCLFMGYLFLLLDLWQISI----SFCK 277
            .:.:.:|      :|:..|:..:|: ::...|..|.....|.:..|..|||.| |::    .||.
  Rat   634 LSSIFLS------VTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLVFLLDSW-IALYNARGFCI 691

  Fly   278 PAGFLGYFFVMAAFFWLSVISLHLWNTFRGSSHKANRFLFEHRFLA----YNTY----------- 327
            ......::|::.:|.|:.:.:.|:                   :||    :|||
  Rat   692 SVAVFLHYFLLVSFTWMGLEAFHM-------------------YLALVKVFNTYIRKYILKFCIV 737

  Fly   328 AWGMAVVLTGI--TVLADNI-VENQDWNPRVGHEGHCWIYTQAWSAMLYF----YGPMVFLIAFN 385
            .||:..|:..|  |:..||. :.:....|....:..|||.:   |.:.|.    |..::||:  |
  Rat   738 GWGIPAVVVSIVLTISPDNYGIGSYGKFPNGTPDDFCWINS---SVVFYITVVGYFCVIFLL--N 797

  Fly   386 ITMFILTAKRILGVKKDIQNFAHRQERKQKLNSDKQTYTFFLRLFIIMGLSWSLEIGSYFSQSNQ 450
            ::|||:...::..:||..|..|.|:...|.|.|       ...|..::|::|..   ::|:
  Rat   798 VSMFIVVLVQLCRIKKKKQLGAQRKTSIQDLRS-------IAGLTFLLGITWGF---AFFA---- 848

  Fly   451 TWANVFLVADYL----NWSQGIIIFILFVLK----RSTWR 482
             |..|.|...||    |..||..|||.:...    |..||
  Rat   849 -WGPVNLTFMYLFAIFNTLQGFFIFIFYCAAKENVRKQWR 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mth	NP_728521.1	Methuselah_N	29..209	CDD:429053	25/116 (22%)
		7tmB3_Methuselah-like	219..488	CDD:410632	70/299 (23%)
		TM helix 2	247..269	CDD:410632	7/21 (33%)
		TM helix 3	277..304	CDD:410632	4/26 (15%)
		TM helix 4	321..341	CDD:410632	10/36 (28%)
		TM helix 5	367..396	CDD:410632	9/32 (28%)
		TM helix 6	418..445	CDD:410632	4/26 (15%)
		TM helix 7	453..478	CDD:410632	10/32 (31%)
Adgrg2	NP_852031.1	GPS	564..608	CDD:460350	12/65 (18%)
		GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098	566..615		12/70 (17%)
		Stachel. /evidence=ECO:0000250|UniProtKB:Q8CJ12	604..615		1/10 (10%)
		7tmB2_GPR64	621..890	CDD:320560	73/313 (23%)
		TM helix 1	623..648	CDD:320560	6/30 (20%)
		TM helix 2	658..680	CDD:320560	7/21 (33%)
		TM helix 3	691..718	CDD:320560	4/45 (9%)
		TM helix 4	733..749	CDD:320560	3/15 (20%)
		TM helix 5	779..802	CDD:320560	7/24 (29%)
		TM helix 6	825..850	CDD:320560	7/39 (18%)
		TM helix 7	854..879	CDD:320560	9/24 (38%)