Protein Alignment mth and mthl12

DIOPT Version :10

• Sequence 1: NP_728521.1
• Gene: mth / 38058
• FlyBaseID: FBgn0023000
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_731791.2
• Gene: mthl12 / 261599
• FlyBaseID: FBgn0045442
• Length: 488
• Species: Drosophila melanogaster
• Alignment Length: 502
• Identity: 177/502 - (35%)
• Similarity: 288/502 - (57%)
• Gaps: 35/502 - (6%)

  Fly     5 LVLRISTVILVVLVIQKSYADILECDYFDTVDISAAQKLQNGSYLFEGLLVPAILTGEYDFRILP 69
            |.|:....:::|.:.:.|.|.|..|.|.:|::||..::| |.:|::|...:||.||||:|::.|.
  Fly     3 LWLKCFCTLIIVTIAKNSSAKIPHCKYDETINISHFKRL-NDAYIYEHFEIPANLTGEFDYKELM 66

  Fly    70 DDSKQKVA-RHIRGCVCKLKPCVRFCCPHDHIMDNGVCYDNMSDE-ELAELD-PFLNVTLDDGSV 131
            |.||.... .::|||:||::||:|.||...:|:.||.|.|.:.:| :|..|| ...::.|.|.::
  Fly    67 DGSKVPTEFPNLRGCICKVRPCIRICCARKNILSNGECSDGVKNEIKLTMLDLTMQDILLTDPTL 131

  Fly   132 SR-----RHFKNELIVQWDLPMPCDGMFYLDNREEQDKYTLFENGTFFRHFDRVTLRKREYCLQH 191
            :.     ::...||::..:...|||.:..|    ::|:||:.::|:...|.....|...:|||..
  Fly   132 AELNMIPQYNSTELLILREQFQPCDEIVSL----KRDEYTILKDGSILLHTSAEILSNDQYCLYP 192

  Fly   192 LTFADGNATSIRIAPHNCL--IVPSITGQTVVMISSLICMVLTIAVYLFVKKLQNLHGKCFICYM 254
            ..::|...| |||....|.  ::|.|...:|:   |::..:||:||||.|:||:||.|||.||.:
  Fly   193 EIYSDFPET-IRIINRRCYRNVMPGIAQLSVI---SVVGFILTLAVYLSVEKLRNLLGKCLICSL 253

  Fly   255 VCLFMGYLFLLLDLWQISISFCKPAGFLGYFFVMAAFFWLSVISLHLWNTFRGSSHKANRFLFEH 319
            ..:||.|....:|.:::..|.|..||::.|||.|:::.|.||:|.|||..|.    ..||...::
  Fly   254 FSMFMEYFIWTMDYFRLLQSICSAAGYMKYFFSMSSYLWFSVVSFHLWELFT----SLNRHEPQY 314

  Fly   320 RFLAYNTYAWGMAVVLTGITVLADNIVEN----QDWNPRVGHEGHCWIYTQAWSAMLYFYG--PM 378
            |||.|||:.|..|.:.|.:....:.:.||    .:|.|.||:.| |.:  :.|::..:||.  |:
  Fly   315 RFLIYNTFVWCTAAIPTVVIFSMNQMWENDPGKSEWLPLVGYFG-CSV--KDWNSSSWFYSHIPI 376

  Fly   379 VFLIAFNITMFILTAKRILGVKKDIQNFAHRQERKQK-LNSDKQTYTFFLRLFIIMGLSWSLEIG 442
            |.|.:||:.||:|||..|..|||.:::||...||... |..:.|||..|:|||:|||.||.|:..
  Fly   377 VILNSFNVIMFVLTAIYIWKVKKGVKSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQL 441

  Fly   443 SYFSQSNQTWAN--VFLVADYLNWSQGIIIFILFVLKRSTWRLLQER 487
            :..::.:....:  |..:..|||.:.||:||:|.:||.||::::.||
  Fly   442 TRLAEDSHLLLDTIVLNLTVYLNAAFGILIFVLLILKGSTFKMIMER 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mth	NP_728521.1	Methuselah_N	29..209	CDD:429053	61/187 (33%)
		7tmB3_Methuselah-like	219..488	CDD:410632	107/278 (38%)
		TM helix 2	247..269	CDD:410632	9/21 (43%)
		TM helix 3	277..304	CDD:410632	13/26 (50%)
		TM helix 4	321..341	CDD:410632	8/19 (42%)
		TM helix 5	367..396	CDD:410632	13/30 (43%)
		TM helix 6	418..445	CDD:410632	13/26 (50%)
		TM helix 7	453..478	CDD:410632	10/26 (38%)
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:429053	61/187 (33%)
		7tmB3_Methuselah-like	220..488	CDD:410632	105/277 (38%)
		TM helix 2	246..268	CDD:410632	9/21 (43%)
		TM helix 3	276..303	CDD:410632	13/26 (50%)
		TM helix 4	316..336	CDD:410632	8/19 (42%)
		TM helix 5	364..394	CDD:410632	13/29 (45%)
		TM helix 6	410..444	CDD:410632	15/33 (45%)
		TM helix 7	449..479	CDD:410632	10/29 (34%)