Protein Alignment mth and Adgrg7

DIOPT Version :10

• Sequence 1: NP_728521.1
• Gene: mth / 38058
• FlyBaseID: FBgn0023000
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_766413.2
• Gene: Adgrg7 / 239853
• MGIID: 2441732
• Length: 785
• Species: Mus musculus
• Alignment Length: 414
• Identity: 82/414 - (19%)
• Similarity: 154/414 - (37%)
• Gaps: 123/414 - (29%)

  Fly   156 LDNREEQDKYTLFENGTFFRHFDRVTLRKREYCLQHLTF-----------ADGNATS-IRIAPHN 208
            ::..|:|.:..:.....|...:|:..||...|...:..|           ..||.|. :|.   |
Mouse   347 INESEQQRQNKVSVEMVFNPTYDKRELRLHSYACVYWNFLINDWDTQGCQKTGNTTEFLRC---N 408

  Fly   209 CLIVPSITGQTVVMIS---------------------SLICMVLTIAVYLFVKKLQNLHGKCFIC 252
            |    |.|....|::|                     |:..:.|||...:..:|::.. ...::.
Mouse   409 C----SHTTNFAVLMSFKKDYKYPKSLDILSNIGCALSIAGLALTILFQILTRKIRKT-SVTWVL 468

  Fly   253 YMVCLFMGYLFLLLDLWQISIS-------------------------------FCKPAGFLGYFF 286
            ..:|..| .:|.||.::.|..|                               .|.....|.::|
Mouse   469 VSLCSSM-LIFNLLFVFGIENSNKNLKTSDSDINVKPENNKIPESDTIETPNPSCTAIAALLHYF 532

  Fly   287 VMAAFFW--LSVISLH--LWNTFRGSSHKANRFLFEHRFLAYNTYAWGMAVVLTGITV-----LA 342
            ::..|.|  ||...|:  |..|.:.        |..|..:..:...||:..::.|:|:     |:
Mouse   533 LLVTFTWNGLSATQLYFLLIRTMKP--------LPRHFIIFISLVGWGVPAIIVGVTIGSIYALS 589

  Fly   343 DNIVENQDWNPRVGHEGHCWI-------YTQA---WSAMLYFYGPMVFLIAFNITMFILTAKRIL 397
            .|   .:.|......|..||:       |.::   ||    |..|:..::..|||:|::...::|
Mouse   590 GN---KRYWELDYRQEEICWLAVPKDNDYARSPLLWS----FIIPVTIILITNITIFVIITVKVL 647

  Fly   398 GVKKDIQNFAHRQERKQKLNSDKQTYTFFLRLFIIMGLSWSLEIGSYFSQSNQTWANVFLVADYL 462
            .  |:.||..    ..:|::|.|:.:: .|.:.::.|::|.|......|..     ::.:|..|:
Mouse   648 W--KNNQNLT----STKKVSSLKKVFS-TLSIAVVFGVTWILAYAMLISND-----DIRIVFSYI 700

  Fly   463 ----NWSQGIIIFILFVLKRSTWR 482
                |.:||:.||||:.::...::
Mouse   701 FCLFNTTQGLQIFILYTVRTKVFQ 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mth	NP_728521.1	Methuselah_N	29..209	CDD:429053	12/64 (19%)
		7tmB3_Methuselah-like	219..488	CDD:410632	66/339 (19%)
		TM helix 2	247..269	CDD:410632	5/21 (24%)
		TM helix 3	277..304	CDD:410632	8/30 (27%)
		TM helix 4	321..341	CDD:410632	4/24 (17%)
		TM helix 5	367..396	CDD:410632	8/31 (26%)
		TM helix 6	418..445	CDD:410632	6/26 (23%)
		TM helix 7	453..478	CDD:410632	9/28 (32%)
Adgrg7	NP_766413.2	GPS	378..418	CDD:460350	10/46 (22%)
		GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098	380..425		11/51 (22%)
		7tmB2_GPR128	428..727	CDD:320385	64/326 (20%)
		TM helix 1	430..455	CDD:320385	4/24 (17%)
		TM helix 2	465..487	CDD:320385	5/22 (23%)
		TM helix 3	523..550	CDD:320385	7/26 (27%)
		TM helix 4	563..583	CDD:320385	4/19 (21%)
		TM helix 5	617..647	CDD:320385	8/33 (24%)
		TM helix 6	661..688	CDD:320385	6/27 (22%)
		TM helix 7	695..720	CDD:320385	9/24 (38%)