DRSC/TRiP Functional Genomics Resources

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Protein Alignment mth and Adgrg4

DIOPT Version :10

Sequence 1:NP_728521.1 Gene:mth / 38058 FlyBaseID:FBgn0023000 Length:522 Species:Drosophila melanogaster
Sequence 2:NP_001349814.1 Gene:Adgrg4 / 236798 MGIID:2685213 Length:3025 Species:Mus musculus


Alignment Length:374 Identity:83/374 - (22%)
Similarity:143/374 - (38%) Gaps:95/374 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   191 HLT----FADGNATSIRIAPHNCLIVPSITGQTVVMISSLICMVLTIAVYLFVKKLQNLHGKCFI 251
            |||    ..|.:.:::.......|::.:.||..:..|...|.||..||   |.|..::...|..|
Mouse  2622 HLTHFGVLMDLSRSTVDAVNERILVIITYTGCGISSIFLGIAMVTYIA---FHKLRKDYPSKILI 2683

  Fly   252 CYMVCLFMGYLFLLLDLWQIS---ISFCKPAGFLGYFFVMAAFFWLSVISLHLW-------NTFR 306
            .....|.|..|..|::.|..|   :..|..|....::|::.:..|:.:.::|::       ||: 
Mouse  2684 NLCTALLMLNLAFLVNSWLTSFQKVGLCITAAVALHYFLLVSLTWMGLEAVHMYFALVKVFNTY- 2747

  Fly   307 GSSHKANRFLFEHRFLAYNTYAWGMAVVLTGI--TVLADNIVENQDWNPRVGHEGHCWI------ 363
                      ..:..|.:....||:..:...|  :|..|.........|      .|||      
Mouse  2748 ----------IPNYILKFCLAGWGIPAITVAIILSVRKDLYGTLSPTTP------FCWIKDDHIF 2796

  Fly   364 YTQAWSAMLYFYGPMVFLIAFNITMFILTAKRILGVKKDIQNFAHRQERKQKLNSDKQTYTFFLR 428
            |.   |.:.||.  ::||:  |::||.....::..||...|    :..:|..||..|.|    :.
Mouse  2797 YI---SVVAYFC--LIFLM--NLSMFCTVLVQLTSVKSQSQ----KTRKKMILNDLKGT----IS 2846

  Fly   429 LFIIMGLSWSLEIGSYFSQSNQTWANVFLVADYL----NWSQGIIIFILF-VLKRST-------- 480
            |..::||:|..   ::|:     |..|.:...||    |..||.:||:.: |:|.|.        
Mouse  2847 LTFLLGLTWGF---AFFA-----WGPVRIFFLYLFAICNTLQGFLIFVFYCVMKESVREQWHMPL 2903

  Fly   481 ---WRLLQ-----------ERNHPKSTRSVISNRSMASRIT---VGTTP 512
               |..|:           ::...|:..|.:...|:.|..|   :|:.|
Mouse  2904 HCRWLRLENFAGWINVRHKQKRLKKNNESKLLTPSLMSTTTFKSIGSVP 2952

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthNP_728521.1 Methuselah_N 29..209 CDD:429053 4/21 (19%)
7tmB3_Methuselah-like 219..488 CDD:410632 69/313 (22%)
TM helix 2 247..269 CDD:410632 6/21 (29%)
TM helix 3 277..304 CDD:410632 4/33 (12%)
TM helix 4 321..341 CDD:410632 4/21 (19%)
TM helix 5 367..396 CDD:410632 8/28 (29%)
TM helix 6 418..445 CDD:410632 6/26 (23%)
TM helix 7 453..478 CDD:410632 9/29 (31%)
Adgrg4NP_001349814.1 TM helix 2 2679..2701 CDD:320663 6/21 (29%)
TM helix 3 2712..2739 CDD:320663 4/26 (15%)
TM helix 4 2754..2770 CDD:320663 2/15 (13%)
TM helix 5 2793..2816 CDD:320663 8/29 (28%)
TM helix 6 2838..2863 CDD:320663 9/36 (25%)
TM helix 7 2867..2892 CDD:320663 8/24 (33%)
LamG <54..162 CDD:473984
DUF5585 201..581 CDD:465521
GPS 2587..2629 CDD:460350 3/6 (50%)
7tmB2_GPR112 2642..2903 CDD:320663 70/303 (23%)
TM helix 1 2644..2669 CDD:320663 7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

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