DRSC/TRiP Functional Genomics Resources

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Protein Alignment mth and Adgrg1

DIOPT Version :10

Sequence 1:NP_728521.1 Gene:mth / 38058 FlyBaseID:FBgn0023000 Length:522 Species:Drosophila melanogaster
Sequence 2:XP_017168066.1 Gene:Adgrg1 / 14766 MGIID:1340051 Length:700 Species:Mus musculus


Alignment Length:375 Identity:82/375 - (21%)
Similarity:148/375 - (39%) Gaps:110/375 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   188 CL-QHLTF---ADGNATSIRIAPHNCLIVPSITGQTVVMISSLICMVLTIAVYLFVKKLQNLHGK 248
            || .|||:   ...::|.:.....:.|.:.|..|   .:||:|.| |.|||.||..::...    
Mouse   390 CLCNHLTYFAVLMVSSTEVEATHKHYLTLLSYVG---CVISALAC-VFTIAAYLCSRRKSR---- 446

  Fly   249 CFICYMVCLFMGYLFLLLDLWQISISF--------------CKPAGFLGYFFVMAAFFWLSVISL 299
               .|.:.:.|.   ||..::.:.:||              |:.:....:|.::|...|:.:...
Mouse   447 ---DYTIKVHMN---LLSAVFLLDVSFLLSEPVALTGSEAACRTSAMFLHFSLLACLSWMGLEGY 505

  Fly   300 HLWNTFRGSSHKANRFLFEHRFLAYNTY-----------AWGMAVVLTGITVLADNIVENQDWNP 353
            :|:           |.:.|    .:.||           .||..|.|  :|::|  :|:..::.|
Mouse   506 NLY-----------RLVVE----VFGTYVPGYLLKLSIVGWGFPVFL--VTLVA--LVDVNNYGP 551

  Fly   354 ----------RVGHEGHCWIYTQAWSAMLYFYG----PMVFLIAFNITMFILTAKRILGVKKDIQ 404
                      ||.:...|||..   |.:.|...    .:|||  ||:.|......:||.::...|
Mouse   552 IILAVRRTPERVTYPSMCWIRD---SLVSYVTNLGLFSLVFL--FNLAMLATMVVQILRLRPHSQ 611

  Fly   405 NFAHRQERKQKLNSDKQTYTFFLRLFIIMGLSWSLEIGSYFSQSNQTWANVFL-VADYLNWSQGI 468
            |:.|              ....|.|.:::||.|:|   .:||.::.|:..|.| :...:...||.
Mouse   612 NWPH--------------VLTLLGLSLVLGLPWAL---VFFSFASGTFQLVILYLFSIITSFQGF 659

  Fly   469 IIFILFVLKRSTWRL-LQERNHPKSTRSVISNRSMASRITVGTTPKNKAR 517
            :||:.:      |.: .|.:..|    |.:.|.|.::::.:.:...:.:|
Mouse   660 LIFLWY------WSMRFQAQGGP----SPLKNNSDSAKLPISSGSTSSSR 699

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthNP_728521.1 Methuselah_N 29..209 CDD:429053 6/24 (25%)
7tmB3_Methuselah-like 219..488 CDD:410632 68/309 (22%)
TM helix 2 247..269 CDD:410632 4/21 (19%)
TM helix 3 277..304 CDD:410632 4/26 (15%)
TM helix 4 321..341 CDD:410632 7/30 (23%)
TM helix 5 367..396 CDD:410632 8/32 (25%)
TM helix 6 418..445 CDD:410632 6/26 (23%)
TM helix 7 453..478 CDD:410632 6/25 (24%)
Adgrg1XP_017168066.1 PLL 42..175 CDD:436599
GAIN_A 186..233 CDD:436625
GPS 358..401 CDD:460350 5/10 (50%)
7tm_GPCRs 413..680 CDD:475119 73/331 (22%)
TM helix 1 416..440 CDD:410628 12/27 (44%)
TM helix 2 450..471 CDD:410628 5/23 (22%)
TM helix 3 483..505 CDD:410628 3/21 (14%)
TM helix 4 525..541 CDD:410628 5/17 (29%)
TM helix 5 574..597 CDD:410628 8/24 (33%)
TM helix 6 616..638 CDD:410628 8/24 (33%)
TM helix 7 644..669 CDD:410628 7/30 (23%)
Blue background indicates that the domain is not in the aligned region.

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