Protein Alignment mth and ADGRG4

DIOPT Version :10

• Sequence 1: NP_728521.1
• Gene: mth / 38058
• FlyBaseID: FBgn0023000
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_722576.3
• Gene: ADGRG4 / 139378
• HGNCID: 18992
• Length: 3080
• Species: Homo sapiens
• Alignment Length: 296
• Identity: 71/296 - (23%)
• Similarity: 121/296 - (40%)
• Gaps: 55/296 - (18%)

  Fly   212 VPSITGQTVVM-------ISSLICMVLTIAVYLFVKKLQNLHGKCFICYMVCLFMGYLFLLLDLW 269
            |.|:..|.:.:       |||:...|..:....|.|..::...|..|.....|.|..|..|::.|
Human  2735 VDSVNEQILALITYTGCGISSIFLGVAVVTYIAFHKLRKDYPAKILINLCTALLMLNLVFLINSW 2799

  Fly   270 QIS---ISFCKPAGFLGYFFVMAAFFWLSVISLHLWNTFRGSSHKANRFLFEHRFLAYNTYAWGM 331
            ..|   :..|..|....::|::.:|.|:.:.::|::...    .|.......:..|.:....||:
Human  2800 LSSFQKVGVCITAAVALHYFLLVSFTWMGLEAVHMYLAL----VKVFNIYIPNYILKFCLVGWGI 2860

  Fly   332 AVVLTGITVLADNIVENQDWNPRVGHEGHCWIYTQA---WSAMLYFYGPMVFLIAFNITMFILTA 393
            ..::..|||    .|:...:.........|||...:   .|.:.||.  ::||:  |::||....
Human  2861 PAIMVAITV----SVKKDLYGTLSPTTPFCWIKDDSIFYISVVAYFC--LIFLM--NLSMFCTVL 2917

  Fly   394 KRILGVKKDIQNFAHRQERKQKLNSDKQTYTFFLRLFIIMGLSWSLEIGSYFSQSNQTWA---NV 455
            .::..||..||    :..||..|:..|.|    :.|..::||:|..   ::|:     |.   |.
Human  2918 VQLNSVKSQIQ----KTRRKMILHDLKGT----MSLTFLLGLTWGF---AFFA-----WGPMRNF 2966

  Fly   456 FLVADYL----NWSQGIIIFILF-VLK---RSTWRL 483
            ||   ||    |..||..||:.. |:|   |..|::
Human  2967 FL---YLFAIFNTLQGFFIFVFHCVMKESVREQWQI 2999

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mth	NP_728521.1	Methuselah_N	29..209	CDD:429053
		7tmB3_Methuselah-like	219..488	CDD:410632	68/289 (24%)
		TM helix 2	247..269	CDD:410632	6/21 (29%)
		TM helix 3	277..304	CDD:410632	5/26 (19%)
		TM helix 4	321..341	CDD:410632	5/19 (26%)
		TM helix 5	367..396	CDD:410632	8/31 (26%)
		TM helix 6	418..445	CDD:410632	6/26 (23%)
		TM helix 7	453..478	CDD:410632	12/35 (34%)
ADGRG4	NP_722576.3	LamG	28..210	CDD:473984
		Herpes_BLLF1	<290..742	CDD:282904
		DUF5585	916..>1280	CDD:465521
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	946..965
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1274..1348
		2A1904	1768..>2089	CDD:273344
		DUF5585	1960..>2240	CDD:465521
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2109..2141
		GPS	2683..2727	CDD:460350
		GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098	2685..2734
		Stachel. /evidence=ECO:0000269|PubMed:35418677	2723..2734
		7tmB2_GPR112	2740..3001	CDD:320663	69/291 (24%)
		TM helix 1	2742..2767	CDD:320663	4/24 (17%)
		TM helix 2	2777..2799	CDD:320663	6/21 (29%)
		TM helix 3	2810..2837	CDD:320663	5/26 (19%)
		TM helix 4	2852..2868	CDD:320663	2/15 (13%)
		TM helix 5	2891..2914	CDD:320663	7/26 (27%)
		TM helix 6	2936..2961	CDD:320663	8/36 (22%)
		TM helix 7	2965..2990	CDD:320663	11/27 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3051..3080