Protein Alignment mth and mthl5

DIOPT Version :10

• Sequence 1: NP_728521.1
• Gene: mth / 38058
• FlyBaseID: FBgn0023000
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: XP_061501242.1
• Gene: mthl5 / 1278843
• VectorBaseID: AGAMI1_000140
• Length: 493
• Species: Anopheles gambiae
• Alignment Length: 272
• Identity: 66/272 - (24%)
• Similarity: 110/272 - (40%)
• Gaps: 60/272 - (22%)

  Fly   223 ISSLICMVLTIAVYLFVKKLQNLHGKCFICYMVCLFMGYLFLLLDLWQISISFCKPAGFL---GY 284
            |:.:|.:|:.| :|..:..|::|.|.......:||.:..   ..||.:|...|.....||   .:
Mosquito   211 IAMIILLVVAI-IYFVLPTLRDLVGNMVTTITMCLIVSQ---AADLVRIFTEFSNHVSFLIADLF 271

  Fly   285 FFV--MAAFFWLSVISLHLWNTFRGSSHKANRFL---FEHRFLAYNTYAWGMAVVLTGITVLADN 344
            |:|  :.|||||:.:..::|..||    ..|.||   ...::..|:.||||....:..|.|.|..
Mosquito   272 FYVSLLGAFFWLNAMGYYIWKMFR----TRNVFLRVSDGRKYCWYSGYAWGCTGTMAAIAVFAHY 332

  Fly   345 IVENQDWNPRVG------------HEGHCWIYTQAWSAMLYFYGPMVFLIAFNITMFILTAKRIL 397
            .::....|..|.            .||...|   :|..:..|:.|:.|:|..||..|:.|.:.|
Mosquito   333 FLDLPGSNRSVAGADTHQSARESFFEGQDNI---SWLGIAVFFTPIAFIIIVNIFFFVTTLRFI- 393

  Fly   398 GVKKDIQNFAHRQER-KQKLNSDKQTYTFFLRLFIIMGLSWSLEIGSYFSQSNQTWANVFLVADY 461
                   |..|...| ..||   :.::..|..:|..|.:||                 :||:..:
Mosquito   394 -------NRMHTYGRIHHKL---RCSFVMFTLIFATMSVSW-----------------LFLILSW 431

  Fly   462 LNWSQGIIIFIL 473
            |::...:.:.|:
Mosquito   432 LHFDGLLYMHII 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mth	NP_728521.1	Methuselah_N	29..209	CDD:429053
		7tmB3_Methuselah-like	219..488	CDD:410632	66/272 (24%)
		TM helix 2	247..269	CDD:410632	4/21 (19%)
		TM helix 3	277..304	CDD:410632	10/31 (32%)
		TM helix 4	321..341	CDD:410632	6/19 (32%)
		TM helix 5	367..396	CDD:410632	9/28 (32%)
		TM helix 6	418..445	CDD:410632	5/26 (19%)
		TM helix 7	453..478	CDD:410632	4/21 (19%)
mthl5	XP_061501242.1	None