Protein Alignment mth and LOC1276880

DIOPT Version :10

• Sequence 1: NP_728521.1
• Gene: mth / 38058
• FlyBaseID: FBgn0023000
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: XP_061496511.1
• Gene: LOC1276880 / 1276880
• VectorBaseID: AGAMI1_002326
• Length: 1064
• Species: Anopheles gambiae
• Alignment Length: 543
• Identity: 150/543 - (27%)
• Similarity: 272/543 - (50%)
• Gaps: 71/543 - (13%)

  Fly     8 RISTVILVVLVIQKSYADILECDYFDTVDISAAQKLQNGSYLFEGLLVPAILTGEYDFRILPDD- 71
            ||...:||:..::.|... |.||:.|:|:|:..::|.|......|     ::..:..:|::..|
Mosquito     5 RIVACLLVLFGVRSSVCS-LPCDFIDSVNITDGERLPNDEIRHNG-----VIYNKTYYRVIDYDY 63

  Fly    72 ----SKQKVARHIRGCVCKLKPCVRFCC-PHDHIMDNGVCYDNMSDEELAELDPFLNVTLDDGSV 131
                :|:.|..::|||:|.::.|||.|| .|:::           .:.....|.:|.:.::..:.
Mosquito    64 QDFATKRYVPNYVRGCLCAVRICVRLCCGEHEYL-----------GKRCTHTDDYLPILVNVSAT 117

  Fly   132 SRRHFKNELIVQWDLPMPCDGMF-YLDNREEQDKYTLFENGTFFRHFDRVTLRKREYCL---QHL 192
            .....:|..:..:....||:.:: .|......|::::..||:.. ..|.:.:::.:|||   |:.
Mosquito   118 EAVDLRNHSLYGFLYGKPCEQVYELLPEESPADEWSIARNGSLI-IADELLIQRNQYCLAPRQNN 181

  Fly   193 TFADGNATSIRIAPHNCLIVPSITGQ-------TVVMISSLICMVLTIAVYLFVKKLQNLHGKCF 250
            .||.|             :|...|.:       .|.|:.|:..::||..||..:..|:|:|||..
Mosquito   182 GFASG-------------LVCFTTNEEFKYNLYPVGMLLSVPFLLLTFFVYACIPDLRNMHGKSL 233

  Fly   251 ICYMVCLFMGYLFLLLDLWQISI-----SFCKPAGFLGYFFVMAAFFWLSVISLHLWNTFRGSSH 310
            :||::.|.:||  .:|.:.|:.:     :.|..:|::.||..|.:||||:|:|..::.||:|.:
Mosquito   234 MCYVLGLSVGY--TVLSMVQLRVFPGLSASCVISGYIVYFSFMVSFFWLNVMSFDIYWTFKGVT- 295

  Fly   311 KANRFLFEHRFLAYNTYAWGMAVVLTGITVLAD--NIVENQDWNPRVGHEGHCWIYTQAWSAMLY 373
             ..|.....:||.|:.||||..::|....::||  :|:... ..|:.| ...|..........||
Mosquito   296 -GVRSSETKKFLLYSLYAWGCPILLVATAIIADYTDILPIY-LRPQFG-TTRCLFVENKLIEFLY 357

  Fly   374 FYGPMVFLIAFNITMFILTAKRILGVKKDIQNFAHRQERKQ--KLNSDKQTYTFFLRLFIIMGLS 436
            .|.|::.|:..|:..|::||.||..::.: .:...|.:.|:  ||::|:..:..:|||||:||::
Mosquito   358 LYMPLLILVFMNVVFFVITALRIYKIQCE-TSVVRRGDSKRHTKLDNDRDRFGLYLRLFIVMGVT 421

  Fly   437 WSLEIGSYFSQSNQTWANVFLVADYLNWSQGIIIFILFVLKRSTWRLLQERNHPKSTRSVISNRS 501
            |||||.|: :..|..|  :|.|:|..|..||.:||.|||||:...||:.::...:..|......|
Mosquito   422 WSLEIISW-AVDNNAW--IFYVSDVCNCIQGFLIFALFVLKQKIKRLIYKKFGIREIRQEQKTSS 483

  Fly   502 MASRIT---VGTTPKNKARNSPL 521
            .::|.|   |.:..::|:.| ||
Mosquito   484 CSTRTTATMVSSYQESKSDN-PL 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mth	NP_728521.1	Methuselah_N	29..209	CDD:429053	39/189 (21%)
		7tmB3_Methuselah-like	219..488	CDD:410632	94/277 (34%)
		TM helix 2	247..269	CDD:410632	8/21 (38%)
		TM helix 3	277..304	CDD:410632	10/26 (38%)
		TM helix 4	321..341	CDD:410632	8/19 (42%)
		TM helix 5	367..396	CDD:410632	9/28 (32%)
		TM helix 6	418..445	CDD:410632	14/26 (54%)
		TM helix 7	453..478	CDD:410632	12/24 (50%)
LOC1276880	XP_061496511.1	None