Protein Alignment mth and mthl11

DIOPT Version :10

• Sequence 1: NP_728521.1
• Gene: mth / 38058
• FlyBaseID: FBgn0023000
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_731479.3
• Gene: mthl11 / 117467
• FlyBaseID: FBgn0045443
• Length: 532
• Species: Drosophila melanogaster
• Alignment Length: 528
• Identity: 204/528 - (38%)
• Similarity: 290/528 - (54%)
• Gaps: 49/528 - (9%)

  Fly     6 VLRISTVILVVLVIQKSYADILECDYFDTVDISAAQKLQNGSYLFEGLLVPAILTGEYDFRILPD 70
            :.|:..::|.:|||.....||..||:||||.:..::||.||||.:|.:::||.|||:||:.|..|
  Fly     3 MFRVEYLLLGILVIGVRSRDIPNCDFFDTVQLRESEKLCNGSYRYEDVVIPAKLTGKYDYEIDYD 67

  Fly    71 DSKQKVARHIRGCVCKLKPCVRFCCPHDHIMDNGVC----YDNMSDEELAELDPFLNVTLDDGSV 131
            ..:..|.:||||||||||.|:||||.|..:|...:|    |:|::.|..      |::|..:|||
  Fly    68 GDRVSVPKHIRGCVCKLKTCIRFCCHHKKLMAGNLCSQDVYENLTYEYT------LDITQLNGSV 126

  Fly   132 SRRHFKNELIVQWDLPMPCDGMFYLD-NREEQDKYTLFENGTFFRHFDRVTLRKREYCLQHLTFA 195
            .::|..|:::||.|||:||:..:.|| .....|.::|:|||:.|||||:..|.|:|:|||....:
  Fly   127 IKKHVLNDMVVQQDLPLPCERHYSLDAETSTYDMWSLYENGSLFRHFDQRYLSKQEFCLQPNPTS 191

  Fly   196 DGNATSIRIAPHNCLIVPSI----------------TGQTVVMISSLICMVLTIAVYLFVKKLQN 244
            .|...|:.:| .||:..||:                .....|..||:..||:|||.||::.|.::
  Fly   192 TGKNYSLIVA-FNCIQKPSMKMAYGRFECVRKSRLSNASIPVKFSSVFFMVITIAAYLWLPKFRS 255

  Fly   245 LHGKCFICYMVCLFMGYLFLLLDL---WQISISFCKPAGFLGYFFVMAAFFWLSVISLHLWNTFR 306
            |||||...|.:||.:.:|..::.|   :::....|...|:.|||.|||.|.||||||..:|..|
  Fly   256 LHGKCCNLYFICLAITFLLNVISLFGIFELKTPICYLTGYAGYFTVMATFLWLSVISFDVWRRF- 319

  Fly   307 GSSHKANRFLFEHR--FLAYNTYAWGMAVVLTGITVLADNIVE-NQD--WNPRVGHEGHCWIYTQ 366
             :..|...|....|  |..||...|..|.:||.|..|.|..|| |.|  :||.|| ...|||:|.
  Fly   320 -AMRKFQVFYKNKRSSFFNYNIIVWSSAGLLTCIIFLVDQFVETNLDNPYNPAVG-VFSCWIFTN 382

  Fly   367 AWSAMLYFYGPMVFLIAFNITMFILTAKRILGVKKDIQNFAHRQERKQKLNSDKQTYTFFLRLFI 431
            .|||..|||.|:..||..|...|.||.:.|....|..|...:..| .|||:.:...|..:.||||
  Fly   383 GWSATFYFYAPLAILIILNCASFFLTTRYIYVENKQNQKVLNNSE-PQKLSRNHANYRIYFRLFI 446

  Fly   432 IMGLSWSLEIGSYFSQSNQTWANVFLVADYLNWSQGIIIFILFVLKRSTWRLLQERNHPKSTRSV 496
            |||.||.|||.::..:....|..:.::.||:|.|||||||:........:||:::|
  Fly   447 IMGGSWFLEIIAFICEMENMWKPLIILNDYINCSQGIIIFVATFCNHEMFRLIRKR--------- 502

  Fly   497 ISNRSMAS 504
            |.||::.|
  Fly   503 IQNRNITS 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mth	NP_728521.1	Methuselah_N	29..209	CDD:429053	79/184 (43%)
		7tmB3_Methuselah-like	219..488	CDD:410632	109/276 (39%)
		TM helix 2	247..269	CDD:410632	8/24 (33%)
		TM helix 3	277..304	CDD:410632	15/26 (58%)
		TM helix 4	321..341	CDD:410632	8/19 (42%)
		TM helix 5	367..396	CDD:410632	13/28 (46%)
		TM helix 6	418..445	CDD:410632	13/26 (50%)
		TM helix 7	453..478	CDD:410632	10/24 (42%)
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:429053	79/184 (43%)
		7tmB3_Methuselah-like	236..504	CDD:410632	108/280 (39%)
		TM helix 2	258..280	CDD:410632	7/21 (33%)
		TM helix 3	291..318	CDD:410632	15/26 (58%)
		TM helix 4	335..355	CDD:410632	8/19 (42%)
		TM helix 5	383..412	CDD:410632	13/28 (46%)
		TM helix 6	433..460	CDD:410632	13/26 (50%)
		TM helix 7	468..493	CDD:410632	10/24 (42%)