Protein Alignment mth and adgrl2b.1

DIOPT Version :10

• Sequence 1: NP_728521.1
• Gene: mth / 38058
• FlyBaseID: FBgn0023000
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: XP_073767727.1
• Gene: adgrl2b.1 / 110437953
• ZFINID: ZDB-GENE-130116-4
• Length: 1467
• Species: Danio rerio
• Alignment Length: 580
• Identity: 124/580 - (21%)
• Similarity: 211/580 - (36%)
• Gaps: 193/580 - (33%)

  Fly    43 LQNGSY-LFEGLLVPAIL----------------TGE-YDFRILPDDSKQKVARHIRGCVCKLKP 89
            |:.|:: |.:.|:.||::                .|: .||| .|..||:.....:...:.||.
Zfish   644 LEEGAFVLADNLIEPAVVRMPAENIMLDVYVLSTDGQIQDFR-FPQTSKRGATIQLSANMVKLN- 706

  Fly    90 CVRFCCPHDHIMDNGVC------YDN--------------MSDEELAELDPFLNVTLDDGSV--- 131
                       ..|||.      |.:              |.|..|......:|..:...|:
Zfish   707 -----------SKNGVAKLVFVLYKHLGHFLSTENATVRLMGDGGLRNHTLTVNSHILSASINKE 760

  Fly   132 SRRHFKNELIVQWDLPMPCDGMFYLDNREEQDKYTLFENGTFFRHFDR--------------VTL 182
            |.|.|.:|.::           |.|::.:.::.:.  .|.:|:.:.:|              .|.
Zfish   761 SSRVFVSEPVI-----------FTLEHLDTENYFN--PNCSFWNYSERSMSGYWSTQGCKLLSTN 812

  Fly   183 RKREYC-LQHLT-FA------DGNATSIRIAPHNCLIVPSITGQTVV----MISSLICMVLTIAV 235
            :....| ..||| ||      |.:|....:  |..|:       ||:    :..||:|:.::|..
Zfish   813 KTHTTCSCSHLTNFAILMVHRDSHAGEGSV--HELLL-------TVITRLGIAVSLVCLAISIFT 868

  Fly   236 YLFVKKLQN----LHGKCFICYMVCLFMGYLFLLLDLWQISISFCKP-------AGFLGYFFVMA 289
            :.|.:.||:    :|..  :|  :.||:..|..|     :.|:..:|       ||.| :||.:|
Zfish   869 FCFFRGLQSDRNTIHKN--LC--INLFIAELLFL-----VGINMTEPPIVCSVIAGVL-HFFFLA 923

  Fly   290 AFFWLSVISLHLWNTFRGSSHKANRFL-----FEHRFLA---YNTYAWGMAVVLTGITVLADNIV 346
            ||.|:.:..:.|             ||     ||..|..   |....:....|:.||:...|
Zfish   924 AFSWMCLEGVQL-------------FLMLVEVFESEFSRRKYYYASGYLFPCVVVGISAAID--- 972

  Fly   347 ENQDWNPRVGHEGHCWIYTQ---AWSAMLYFYGPMVFLIAFNITMFILT----AKRILGVKKDIQ 404
                 ....|.:..||:...   .||    |.||:.|:|..|:...::|    .|..:.:|.|
Zfish   973 -----YKSYGTKKACWLRVDNHFIWS----FIGPVTFIILLNLIFLVVTMYKMVKHSMSMKPD-- 1026

  Fly   405 NFAHRQERKQKLNSDKQTYTFFLRLFIIMGLSWSLEIGSYFSQSNQTWANVFLVADYLNWSQGII 469
                    ..:|.|.:........|..::.|:||..: .:.:.|:...|.:|.:   .|..||:.
Zfish  1027 --------SSRLESIRSWVFGAFALLCLLCLTWSFGL-LFLNDSSVIMAYLFSI---FNTLQGMF 1079

  Fly   470 IFILFVLKRSTWRLLQE-----------RNHP-KSTRSVISNRSMASRITVGTTPKNKAR 517
            ||:...|.:.  ::.:|           |.|| :...||  |:|.|||.|...:...::|
Zfish  1080 IFVFHCLLQK--KVRKEYSKCFRQSQCCRTHPSEGPHSV--NKSSASRSTARYSSATQSR 1135

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mth	NP_728521.1	Methuselah_N	29..209	CDD:429053	43/228 (19%)
		7tmB3_Methuselah-like	219..488	CDD:410632	68/309 (22%)
		TM helix 2	247..269	CDD:410632	5/21 (24%)
		TM helix 3	277..304	CDD:410632	11/33 (33%)
		TM helix 4	321..341	CDD:410632	5/22 (23%)
		TM helix 5	367..396	CDD:410632	10/32 (31%)
		TM helix 6	418..445	CDD:410632	5/26 (19%)
		TM helix 7	453..478	CDD:410632	8/24 (33%)
adgrl2b.1	XP_073767727.1	None