Protein Alignment mth and LOC103909395

DIOPT Version :10

• Sequence 1: NP_728521.1
• Gene: mth / 38058
• FlyBaseID: FBgn0023000
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: XP_073762768.1
• Gene: LOC103909395 / 103909395
• -ID: -
• Length: 833
• Species: Danio rerio
• Alignment Length: 580
• Identity: 123/580 - (21%)
• Similarity: 207/580 - (35%)
• Gaps: 177/580 - (30%)

  Fly     1 MKTLLVLRISTVILVVLVIQKSYADILECDYFDTVDISAAQKLQNGSYLFEGLLVPAILTGEYDF 65
            :|.||. :|..:....|.:.| ..|||      ||..:|::|:...|........||.| ..|..
Zfish   321 LKNLLE-QIENITAQELPLNK-VTDIL------TVAFNASEKISVSSSSSSSSASPAQL-ASYGT 376

  Fly    66 RIL------------PDDSKQKVA---RHIRGCVCKLKPCVRF-CCPHDHIMDNGVCYD------ 108
            ::|            |.|:...|:   ..:.|.|..:.|.|.. ..|..:..::.:..|
Zfish   377 KVLKSSEKLISTLVKPTDTSANVSFTLAAVEGKVFMVGPQVTLDKIPQLYTTNSSINIDLIGIAK 441

  Fly   109 NMSD-------------EELAELDPFLNVTLDDGSVSRRHFKNEL--IVQWDLPMPCDGMFYLDN 158
            |.:|             |.|.:.| |.|.|.|.       .|..:  ::...||
Zfish   442 NNNDRSAAVAFMSYTTMENLLKAD-FFNTTNDT-------IKTMMSTVISATLP----------- 487

  Fly   159 REEQDKYTLFENGTFFRHFDRVTLRKREY----------------------------------CL 189
            :......|...|.| |||.       ||:                                  |:
Zfish   488 KTSNTALTKAVNFT-FRHI-------REFEPSGSLSCVYWNISEWIVDGCSVLNSNSSHTVCSCV 544

  Fly   190 QHLTFADGNATSIRIAPHNCLIVPSITGQTVVMISSLICMVLTIAVYLFVKKLQNLHGKCFICYM 254
            ...|||....||....|.:.|.:..:    |.:|..|:...|.:..:...:....::....|...
Zfish   545 HLSTFALIMQTSSSPPPSDLLELLGL----VCVIVGLVFFSLALLSFALCQWSPGVNNVARINIC 605

  Fly   255 VCLFMGYLFLLLDLWQISISFCKP--------AGFLGYFFVMAAFFWLSVISLHLW----NTFRG 307
            :.|...:|..||.  |..:|..:|        ||.| :|..::||.|:.:.::.|:    |..:.
Zfish   606 ISLLSAHLLFLLT--QQFLSLIRPQQVLCVVIAGLL-HFLFLSAFVWMFIEAVLLFICVKNLSQI 667

  Fly   308 SSHKANRFLFEHRFLAYNTYAWGMAVVLTGITVLADNIVENQDWNPRVGHEGHCWI-YTQA--WS 369
            ||.|  :.:....||....|...:.||...|.::.:.....|           ||| |.:.  ||
Zfish   668 SSKK--KEVLSSGFLCVIGYLVALVVVCVSIGLVPEGYGSEQ-----------CWIKYDKGFIWS 719

  Fly   370 AMLYFYGPMVFLIAFNITMFILTAKRILGVKKDIQNFAHRQERKQKLNSD----KQTYTFFLRL- 429
                |.||:..::|.|:.:||   :.|:.:|..:.|          ||::    |||.....:.
Zfish   720 ----FLGPVCVILALNLILFI---RIIIILKSALSN----------LNAEVSQMKQTKVMVFKTL 767

  Fly   430 --FIIMGLSWSLEIGSYFSQSNQTWANVFLVADYLNWSQGIIIFILFV-----LKRSTWR 482
              |:::|..|.|   .:|:.|::....:||:   ||..||..||:::.     :::..|:
Zfish   768 GQFVVLGCPWIL---GFFTNSSEMLQILFLI---LNSQQGTFIFLIYCVLNNEIRQQYWK 821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mth	NP_728521.1	Methuselah_N	29..209	CDD:429053	46/250 (18%)
		7tmB3_Methuselah-like	219..488	CDD:410632	67/291 (23%)
		TM helix 2	247..269	CDD:410632	5/21 (24%)
		TM helix 3	277..304	CDD:410632	9/38 (24%)
		TM helix 4	321..341	CDD:410632	6/19 (32%)
		TM helix 5	367..396	CDD:410632	9/30 (30%)
		TM helix 6	418..445	CDD:410632	7/33 (21%)
		TM helix 7	453..478	CDD:410632	8/29 (28%)
LOC103909395	XP_073762768.1	None