DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl10 and ADGRG1

DIOPT Version :10

Sequence 1:NP_788446.2 Gene:mthl10 / 38057 FlyBaseID:FBgn0035132 Length:585 Species:Drosophila melanogaster
Sequence 2:XP_005256294.1 Gene:ADGRG1 / 9289 HGNCID:4512 Length:698 Species:Homo sapiens


Alignment Length:553 Identity:109/553 - (19%)
Similarity:193/553 - (34%) Gaps:150/553 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 DTVNLTGHRLFPNGSYDYYGTIVPAELVGTYD-YIHS-SLTERIEVREHVRGCVCKFKSCLNICC 122
            |.:|.|..:|.|.              .|..| :||| ...|:.|:.|:            ::..
Human   236 DRINATVWKLQPT--------------AGLQDLHIHSRQEEEQSEIMEY------------SVLL 274

  Fly   123 PWRQVF--------NSEVDGCIIDHSDNRTWPDPPMLNITFRNESTILVNMFTQFAIQSFR---- 175
            | |.:|        .:|....::|.|....:.|        :|.|.:|........:|:.:    
Human   275 P-RTLFQRTKGRSGEAEKRLLLVDFSSQALFQD--------KNSSQVLGEKVLGIVVQNTKVANL 330

  Fly   176 --PCPKMFSLQPETNN-------W-DDYLLFENGSMLRVDDKLLIRKNE---FCMVPTYVNESDM 227
              |....|..|.:..|       | :|..|...|.......:.:.|:.:   ||...||      
Human   331 TEPVVLTFQHQLQPKNVTLQCVFWVEDPTLSSPGHWSSAGCETVRRETQTSCFCNHLTY------ 389

  Fly   228 FYTIHPANCDMQDDHSTVKIINSY-AMMFSIPFMMLTIAVYLL----IPELRNQHGKSLVCYL-I 286
            |..:..::.::...|.....:.|| ..:.|....::|||.||.    :|..|.....::..:: :
Human   390 FAVLMVSSVEVDAVHKHYLSLLSYVGCVVSALACLVTIAAYLCSRVPLPCRRKPRDYTIKVHMNL 454

  Fly   287 GLSVGYSSLCYVQLYQVDATG--VTCKVFGYTAYFFFMGAYMWLSVISFDLWHNFRGTRGINRFQ 349
            .|:|......::....|..||  ..|:......:|..:....|:            |..|     
Human   455 LLAVFLLDTSFLLSEPVALTGSEAGCRASAIFLHFSLLTCLSWM------------GLEG----- 502

  Fly   350 EKKRFLFYSLYSWGIALVFLAF-TYCAQQLTNLPANLKPGIGDGVY-----CWLDMSNWAAMIYF 408
                   |:||    .||...| ||....|..|.|   .|.|..::     ..:|:.|       
Human   503 -------YNLY----RLVVEVFGTYVPGYLLKLSA---MGWGFPIFLVTLVALVDVDN------- 546

  Fly   409 YGPILAIV--------------VANTIMFIMTAIKIHGV--QREMARIIASENSTKNLRTEKDKR 457
            ||||:..|              :.::::..:|.:.:..:  ...||.:.........||....| 
Human   547 YGPIILAVHRTPEGVIYPSMCWIRDSLVSYITNLGLFSLVFLFNMAMLATMVVQILRLRPHTQK- 610

  Fly   458 FYRAWSNYRFGLFLRLFLIMGITWLTELISYFVGSDKGWSKLFYISDLANAMQGFLIFMLF-VMK 521
                ||:..  ..|.|.|::|:.|.....|:..|:.:  ..:.|:..:..:.||||||:.: .|:
Human   611 ----WSHVL--TLLGLSLVLGLPWALIFFSFASGTFQ--LVVLYLFSIITSFQGFLIFIWYWSMR 667

  Fly   522 KKVKHLITNRCSSVRDGSNQRQSQYSTKTTSSS 554
            .:.:    ...|.::..|:..:...|:.:||||
Human   668 LQAR----GGPSPLKSNSDSARLPISSGSTSSS 696

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl10NP_788446.2 Methuselah_N 56..236 CDD:429053 38/202 (19%)
7tmB3_Methuselah-like 242..533 CDD:410632 64/321 (20%)
TM helix 1 244..269 CDD:410632 7/25 (28%)
TM helix 2 278..300 CDD:410632 2/22 (9%)
TM helix 3 311..338 CDD:410632 2/26 (8%)
TM helix 4 354..374 CDD:410632 7/20 (35%)
TM helix 5 401..430 CDD:410632 7/42 (17%)
TM helix 6 446..489 CDD:410632 11/42 (26%)
TM helix 7 497..522 CDD:410632 8/25 (32%)
ADGRG1XP_005256294.1 PLL 34..167 CDD:436599
GAIN_A 178..225 CDD:436625
GPS 350..393 CDD:460350 10/48 (21%)
7tm_GPCRs 405..679 CDD:475119 64/324 (20%)
TM helix 1 408..432 CDD:320661 7/23 (30%)
TM helix 2 448..469 CDD:320661 2/20 (10%)
TM helix 3 481..503 CDD:320661 4/45 (9%)
TM helix 4 523..539 CDD:320661 4/18 (22%)
TM helix 5 572..595 CDD:320661 3/22 (14%)
TM helix 6 614..636 CDD:320661 6/23 (26%)
TM helix 7 642..667 CDD:320661 7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

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