Protein Alignment mthl10 and ADGRE3

DIOPT Version :10

• Sequence 1: NP_788446.2
• Gene: mthl10 / 38057
• FlyBaseID: FBgn0035132
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_115960.2
• Gene: ADGRE3 / 84658
• HGNCID: 23647
• Length: 652
• Species: Homo sapiens
• Alignment Length: 677
• Identity: 130/677 - (19%)
• Similarity: 220/677 - (32%)
• Gaps: 229/677 - (33%)

  Fly     8 PGGSLYCGVTLLGVLCLVVFRLIPGIPFGTYVMAERDHYHTIDDPNVPCNFYDTVNLTGHRL--- 69
            |..|:|||   ...:|.                            ||..:||... :.|:||
Human    73 PPYSVYCG---FNAVCY----------------------------NVEGSFYCQC-VPGYRLHSG 105

  Fly    70 ---FPNGSYDYYGTIVPAELVGTYDYIHSSLTERIEVREHVRGCVCKFKSCLNICCPWRQVFNSE 131
               |.|.:.:            |.....||.|  .|.|:.::..|.||:|.|.....||.....|
Human   106 NEQFSNSNEN------------TCQDTTSSKT--TEGRKELQKIVDKFESLLTNQTLWRTEGRQE 156

  Fly   132 VDG---CIIDHSDNR----TWPDPPMLNITFRNESTILVNMFTQFAIQSFRPCPKMFSLQPETNN 189
            :..   .|:...:::    ...||....:..:|:|   |.:.||....:.....|.|:|..:.|:
Human   157 ISSTATTILRDVESKVLETALKDPEQKVLKIQNDS---VAIETQAITDNCSEERKTFNLNVQMNS 218

  Fly   190 WD--------------DYLLFENGSML----------RVDDKLLI-------------------- 210
            .|              ..:.|.:.|.|          .:|.|..:
Human   219 MDIRCSDIIQGDTQGPSAIAFISYSSLGNIINATFFEEMDKKDQVYLNSQVVSAAIGPKRNVSLS 283

  Fly   211 ---------------RKNEFCMVPTYVNES-----DMFYTIH------PANCD------------ 237
                           .|..||:......:.     |..:.||      ..||.
Human   284 KSVTLTFQHVKMTPSTKKVFCVYWKSTGQGSQWSRDGCFLIHVNKSHTMCNCSHLSSFAVLMALT 348

  Fly   238 MQDDHSTVKIINSYAMMFSIPFMMLTIAVYLLIPELRNQHGKSLVCYLIGLSVGYSSLC-----Y 297
            .|::...:.:|....:..|:..::|....:||...:||. ..||...|        |||     .
Human   349 SQEEDPVLTVITYVGLSVSLLCLLLAALTFLLCKAIRNT-STSLHLQL--------SLCLFLAHL 404

  Fly   298 VQLYQVDAT--GVTCKVFGYTAYFFFMGAYMWLSVISFDLWHNFRGTRGINRFQEKKRFLFYSLY 360
            :.|..:|.|  .|.|.:.....::.::.|:.|:.:....|:...|....:| :....|.:.:.::
Human   405 LFLVGIDRTEPKVLCSIIAGALHYLYLAAFTWMLLEGVHLFLTARNLTVVN-YSSINRLMKWIMF 468

  Fly   361 SWGIALVFLAFTYCAQQLTNLPANLKPGIGDGVYCWLDMSN---WAAMIYFYGPILAIVVANTIM 422
            ..|..:..:.....|....:|       .|....|||.:..   |:    |.||:.||..||.::
Human   469 PVGYGVPAVTVAISAASWPHL-------YGTADRCWLHLDQGFMWS----FLGPVCAIFSANLVL 522

  Fly   423 FIMTAIKIHGVQREMARIIASENSTKNLRTEKDKRFYRAWSNYRFGLFLRLFLIMGITWLTELIS 487
            ||:.   ...::|:::.:.:..::.:|.|.            ..|....:|| |:|.||...|:.
Human   523 FILV---FWILKRKLSSLNSEVSTIQNTRM------------LAFKATAQLF-ILGCTWCLGLLQ 571

  Fly   488 YFVGSDKGWSKLFYISDLANAMQGFLIFMLFVMKKKVKHLITNRCSSVRDGSNQRQSQY------ 546
              ||  .....:.|:..:.|::|||.||:::.:.                 |.|.|.||
Human   572 --VG--PAAQVMAYLFTIINSLQGFFIFLVYCLL-----------------SQQVQKQYQKWFRE 615

  Fly   547 --------STKTTSSSVANLSLHEKPS 565
                    .|.|.||.:...|   |||
Human   616 IVKSKSESETYTLSSKMGPDS---KPS 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl10	NP_788446.2	Methuselah_N	56..236	CDD:429053	45/262 (17%)
		7tmB3_Methuselah-like	242..533	CDD:410632	61/300 (20%)
		TM helix 1	244..269	CDD:410632	3/24 (13%)
		TM helix 2	278..300	CDD:410632	6/26 (23%)
		TM helix 3	311..338	CDD:410632	3/26 (12%)
		TM helix 4	354..374	CDD:410632	1/19 (5%)
		TM helix 5	401..430	CDD:410632	10/31 (32%)
		TM helix 6	446..489	CDD:410632	10/42 (24%)
		TM helix 7	497..522	CDD:410632	7/24 (29%)
ADGRE3	NP_115960.2	EGF_CA	67..104	CDD:238011	13/62 (21%)
		GPS	304..344	CDD:460350	6/39 (15%)
		7tm_GPCRs	353..614	CDD:475119	66/318 (21%)
		TM helix 1	356..380	CDD:410628	3/23 (13%)
		TM helix 2	389..410	CDD:410628	7/28 (25%)
		TM helix 3	420..442	CDD:410628	2/21 (10%)
		TM helix 4	466..482	CDD:410628	1/15 (7%)
		TM helix 5	501..524	CDD:410628	8/26 (31%)
		TM helix 6	551..573	CDD:410628	8/24 (33%)
		TM helix 7	577..602	CDD:410628	7/41 (17%)