Protein Alignment mthl10 and CALCR

DIOPT Version :10

• Sequence 1: NP_788446.2
• Gene: mthl10 / 38057
• FlyBaseID: FBgn0035132
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_001158209.2
• Gene: CALCR / 799
• HGNCID: 1440
• Length: 490
• Species: Homo sapiens
• Alignment Length: 489
• Identity: 88/489 - (17%)
• Similarity: 177/489 - (36%)
• Gaps: 132/489 - (26%)

  Fly   136 IIDHSDNRTWP--DP-PMLNITFRNESTILVNMFTQF-AIQSFRPCPKMFSLQPETN-NWDDYLL 195
            |:....|:|:|  :| |.|.:..|.:.     |..|: .....:..|......|..| .||.:|.
Human    22 ILPAFSNQTYPTIEPKPFLYVVGRKKM-----MDAQYKCYDRMQQLPAYQGEGPYCNRTWDGWLC 81

  Fly   196 FENGSMLRVDDKLLIRKNEFC-----------MVPTYVNESDMFYTIHP------ANCDMQDDHS 243
            ::       |....:...:||           .|..|.:|..:::. ||      :|..|.:..:
Human    82 WD-------DTPAGVLSYQFCPDYFPDFDPSEKVTKYCDEKGVWFK-HPENNRTWSNYTMCNAFT 138

  Fly   244 TVKIINSYAMMF--------SIPFMMLTIAVYLLIPEL--------RNQHGKSLVCYLIGLS--- 289
            ..|:.|:|.:.:        ||..:::::.:::...:|        :.:...||.|..:.|.
Human   139 PEKLKNAYVLYYLAIVGHSLSIFTLVISLGIFVFFRKLTTIFPLNWKYRKALSLGCQRVTLHKNM 203

  Fly   290 ----VGYSSLCYVQLYQVDATG-------VTCKVFGYTAYFFFMGAYMW----------LSVISF 333
                :..|.:..:.|.:|...|       |:||:..:...:.....|.|          |.|::.
Human   204 FLTYILNSMIIIIHLVEVVPNGELVRRDPVSCKILHFFHQYMMACNYFWMLCEGIYLHTLIVVAV 268

  Fly   334 DLWHNFRGTRGINRFQEKKRFLFYSLYSWGIALVFLAFTYCAQQLTNLPANLKPGIGDGVY---- 394
                          |.||:|..:|.|..||..||              |..:. .|...||
Human   269 --------------FTEKQRLRWYYLLGWGFPLV--------------PTTIH-AITRAVYFNDN 304

  Fly   395 CWLDMSNWAAMIYFYGPILAIVVANTIMFIMTAIKIHGVQREMARIIASENSTKNLRTEKDKRFY 459
            |||.:......| .:||::|.:|.| ..|::..:::         ::.....|....:....:..
Human   305 CWLSVETHLLYI-IHGPVMAALVVN-FFFLLNIVRV---------LVTKMRETHEAESHMYLKAV 358

  Fly   460 RAWSNYRFGLFLRLFLIMGITWLTELISYFVGSDKGWSKLF-YISDLANAMQGFLIFMLFVM-KK 522
            :|        .:.|..::||.:   ::..:..|:|...|:: |:.......|||.:..::.. ..
Human   359 KA--------TMILVPLLGIQF---VVFPWRPSNKMLGKIYDYVMHSLIHFQGFFVATIYCFCNN 412

  Fly   523 KVKHLITNRCSSVRDGSNQRQSQYSTKTTSSSVA 556
            :|:..:..:.:..:...|||..:..:..::.:.|
Human   413 EVQTTVKRQWAQFKIQWNQRWGRRPSNRSARAAA 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl10	NP_788446.2	Methuselah_N	56..236	CDD:429053	24/121 (20%)
		7tmB3_Methuselah-like	242..533	CDD:410632	58/336 (17%)
		TM helix 1	244..269	CDD:410632	5/32 (16%)
		TM helix 2	278..300	CDD:410632	5/28 (18%)
		TM helix 3	311..338	CDD:410632	5/36 (14%)
		TM helix 4	354..374	CDD:410632	6/19 (32%)
		TM helix 5	401..430	CDD:410632	7/28 (25%)
		TM helix 6	446..489	CDD:410632	5/42 (12%)
		TM helix 7	497..522	CDD:410632	5/26 (19%)
CALCR	NP_001158209.2	HRM	69..137	CDD:397086	15/75 (20%)
		7tmB1_calcitonin_R	145..434	CDD:341343	59/339 (17%)
		TM helix 1	147..172	CDD:341343	2/24 (8%)
		TM helix 2	197..219	CDD:341343	2/21 (10%)
		TM helix 3	236..263	CDD:341343	3/26 (12%)
		TM helix 4	275..295	CDD:341343	7/34 (21%)
		TM helix 5	310..339	CDD:341343	7/39 (18%)
		TM helix 6	353..380	CDD:341343	4/37 (11%)
		TM helix 7	386..411	CDD:341343	5/24 (21%)