DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl10 and ADGRB2

DIOPT Version :10

Sequence 1:NP_788446.2 Gene:mthl10 / 38057 FlyBaseID:FBgn0035132 Length:585 Species:Drosophila melanogaster
Sequence 2:NP_001351786.1 Gene:ADGRB2 / 576 HGNCID:944 Length:1585 Species:Homo sapiens


Alignment Length:403 Identity:81/403 - (20%)
Similarity:152/403 - (37%) Gaps:130/403 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   246 KIINSYAMMFSIPFMMLTIAVYLLIPELRNQHGKSLVCYLIGLSVGYSSLCYVQLYQVDATGVTC 310
            :.|.|...:..:.|.:..:|..:||              |:|.|            :|.:.|| |
Human   959 RFIKSERSIILLNFCLSILASNILI--------------LVGQS------------RVLSKGV-C 996

  Fly   311 KVFGYTAYFFFMGAYMWLSVISFDLWHNFRGTRGINRFQ-EKKRFLFYSLYSWGIALVFLAFTYC 374
            .:.....:|||:.::.|   :..:.|.::....|..|.: .:||||   ...||:..:.:|    
Human   997 TMTAAFLHFFFLSSFCW---VLTEAWQSYLAVIGRMRTRLVRKRFL---CLGWGLPALVVA---- 1051

  Fly   375 AQQLTNLPANLKPGIGDGVYCWLDMSNWAAMIY-FYGPILAIVVANTIMFIMTAIKIHGVQREMA 438
                .::......|.|...||||.:.  ..::| |.||...||:.|.::.|:...|:      ||
Human  1052 ----VSVGFTRTKGYGTSSYCWLSLE--GGLLYAFVGPAAVIVLVNMLIGIIVFNKL------MA 1104

  Fly   439 RIIASENSTKN-------------------------LRTEKDKRFYRA--WSNYRFGLFLRLFLI 476
            |...|:.|.|.                         |.:....|...|  ||:      ..:..:
Human  1105 RDGISDKSKKQRAGSERCPWASLLLPCSACGAVPSPLLSSASARNAMASLWSS------CVVLPL 1163

  Fly   477 MGITWLTELISYFVGSDKGWSKLFY-ISDLANAMQGFLIFMLF-VMKKKVKHLITNRC------- 532
            :.:||::.:::.   :|:. |.||. :..:.|:.|||:|..:. .::::|:.::  :|       
Human  1164 LALTWMSAVLAM---TDRR-SVLFQALFAVFNSAQGFVITAVHCFLRREVQDVV--KCQMGVCRA 1222

  Fly   533 -------SSVRDGSNQRQSQY-------------------STKTTSSSVANLSLHEKPSVEKPLV 571
                   .|.::|..|..|.:                   :..|.:.:::.|||.|.   |:|. 
Human  1223 DESEDSPDSCKNGQLQILSDFEKDVDLACQTVLFKEVNTCNPSTITGTLSRLSLDED---EEPK- 1283

  Fly   572 ISSSVDPQKTTIF 584
             |..|.|:.:..|
Human  1284 -SCLVGPEGSLSF 1295

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl10NP_788446.2 Methuselah_N 56..236 CDD:429053
7tmB3_Methuselah-like 242..533 CDD:410632 66/331 (20%)
TM helix 1 244..269 CDD:410632 4/22 (18%)
TM helix 2 278..300 CDD:410632 3/21 (14%)
TM helix 3 311..338 CDD:410632 5/26 (19%)
TM helix 4 354..374 CDD:410632 5/19 (26%)
TM helix 5 401..430 CDD:410632 8/29 (28%)
TM helix 6 446..489 CDD:410632 9/69 (13%)
TM helix 7 497..522 CDD:410632 8/26 (31%)
ADGRB2NP_001351786.1 AGRB_N 38..230 CDD:465991
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 229..271
TSP1 314..362 CDD:214559
TSP1 367..417 CDD:214559
TSP1 422..472 CDD:214559
TSP1 478..528 CDD:214559
HormR 531..595 CDD:214468
GAIN 614..>769 CDD:465137
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 767..806
GPS 870..923 CDD:197639
GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098 874..924
7tmB2_BAI2 929..1219 CDD:320654 66/320 (21%)
TM helix 1 931..956 CDD:320654
TM helix 2 966..988 CDD:320654 6/35 (17%)
TM helix 3 997..1025 CDD:320654 5/30 (17%)
TM helix 4 1035..1055 CDD:320654 7/30 (23%)
TM helix 5 1073..1102 CDD:320654 8/30 (27%)
TM helix 6 1149..1176 CDD:320654 5/35 (14%)
TM helix 7 1181..1206 CDD:320654 7/24 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1359..1385
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1423..1454
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1498..1585
Blue background indicates that the domain is not in the aligned region.

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