Protein Alignment mthl10 and ADGRB1

DIOPT Version :10

• Sequence 1: NP_788446.2
• Gene: mthl10 / 38057
• FlyBaseID: FBgn0035132
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: XP_016869180.1
• Gene: ADGRB1 / 575
• HGNCID: 943
• Length: 1663
• Species: Homo sapiens
• Alignment Length: 362
• Identity: 69/362 - (19%)
• Similarity: 143/362 - (39%)
• Gaps: 81/362 - (22%)

  Fly   256 SIPFMMLTIAVYLLIPELRNQHGKSLVCYLIGLSVGYSSLCYVQLYQVDATG-VTCKVFGYTAYF 319
            |:..:||.|....:...:|::....|:.:.:.:   .||...:.:.|..... |.|.:.....:|
Human   959 SLTLLMLVIIYVSVWRYIRSERSVILINFCLSI---ISSNALILIGQTQTRNKVVCTLVAAFLHF 1020

  Fly   320 FFMGAYMWLSVISFDLWHNFRGTRG--INRFQEKKRFLFYSLYSWGIALVFLA----FTYCAQQL 378
            ||:.::.|   :..:.|.::....|  .||. .:||||   ...||:..:.:|    ||..
Human  1021 FFLSSFCW---VLTEAWQSYMAVTGHLRNRL-IRKRFL---CLGWGLPALVVAISVGFTKA---- 1074

  Fly   379 TNLPANLKPGIGDGVYCWLDMSNWAAMIY-FYGPILAIVVANTIMFIMTAIKI------------ 430
                    .|.....||||.:.  ..::| |.||..|:|:.|.::.|:...|:
Human  1075 --------KGYSTMNYCWLSLE--GGLLYAFVGPAAAVVLVNMVIGILVFNKLVSKDGITDKKLK 1129

  Fly   431 --------HGVQREM----ARIIASENSTKNLRTEKDKRFYRAWSNYRFGLFLRLFL--IMGITW 481
                    |.:.|.:    ..::::.::|.:           |.||....|:....:  ::.:||
Human  1130 ERAGQPSPHPLGRALKCAECGVLSAADATSD-----------ATSNAMASLWSSCVVLPLLALTW 1183

  Fly   482 LTELISYFVGSDKGWSKLFYISDLANAMQGFLIFMLF-VMKKKVKHLITNRCSSVRDGSNQRQSQ 545
            ::.:::........:..||.:.|   :::||:|.|:. :::::|:..:  :|..|     .||.:
Human  1184 MSAVLAVTDRRSALFQILFAVFD---SLEGFVIVMVHCILRREVQDAV--KCRVV-----DRQEE 1238

  Fly   546 YSTKTTSSSVANLSLHEKPSVEKPLVISSSVDPQKTT 582
             ....:..|..|.........||.:.::....|:..|
Human  1239 -GNGDSGGSFQNGHAQLMTDFEKDVDLACRSGPEAVT 1274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl10	NP_788446.2	Methuselah_N	56..236	CDD:429053
		7tmB3_Methuselah-like	242..533	CDD:410632	59/311 (19%)
		TM helix 1	244..269	CDD:410632	4/12 (33%)
		TM helix 2	278..300	CDD:410632	3/21 (14%)
		TM helix 3	311..338	CDD:410632	5/26 (19%)
		TM helix 4	354..374	CDD:410632	7/23 (30%)
		TM helix 5	401..430	CDD:410632	8/29 (28%)
		TM helix 6	446..489	CDD:410632	7/44 (16%)
		TM helix 7	497..522	CDD:410632	7/25 (28%)
ADGRB1	XP_016869180.1	TSP1	359..407	CDD:214559
		TSP1	412..462	CDD:214559
		TSP1	525..575	CDD:214559
		HormR	577..643	CDD:214468
		GAIN	661..859	CDD:465137
		GPS	880..938	CDD:197639
		7tmB2_BAI_Adhesion_VII	944..1234	CDD:320379	61/319 (19%)
		TM helix 1	946..971	CDD:320379	4/11 (36%)
		TM helix 2	981..1003	CDD:320379	3/24 (13%)
		TM helix 3	1012..1040	CDD:320379	5/30 (17%)
		TM helix 4	1050..1070	CDD:320379	7/22 (32%)
		TM helix 5	1088..1117	CDD:320379	8/30 (27%)
		TM helix 6	1164..1191	CDD:320379	4/26 (15%)
		TM helix 7	1196..1221	CDD:320379	7/27 (26%)
		AGRB_N	41..216	CDD:465991
		TSP1	264..314	CDD:214559