Protein Alignment mthl10 and Adgre4

DIOPT Version :10

• Sequence 1: NP_788446.2
• Gene: mthl10 / 38057
• FlyBaseID: FBgn0035132
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_631877.2
• Gene: Adgre4 / 52614
• MGIID: 1196464
• Length: 689
• Species: Mus musculus
• Alignment Length: 348
• Identity: 67/348 - (19%)
• Similarity: 137/348 - (39%)
• Gaps: 89/348 - (25%)

  Fly   243 STVKIINSYAMMFSIPFMMLTIAVYLLIPELRNQ----HGKSLVCYLIGLSVGYSSLCYVQLYQV 303
            |.:.:|....:..|:..:.|....:||...::|.    |.:..:|..:      :.|.::.....
Mouse   344 SALSVITYVGLSLSLLCLFLAAITFLLCRPIQNTSTTLHLQLSICLFL------ADLLFLTGINR 402

  Fly   304 DATGVTCKVFGYTAYFFFMGAYMWLSVISFDLW---HNFRGTRGINRFQEKKRFLF---YSLYSW 362
            ....|.|.:.....::.::.::||:.:....|:   .|.:.....|..:.||||::   |.|.::
Mouse   403 TKPKVLCSIIAGMLHYLYLASFMWMFLEGLHLFLTVSNLKVANYSNSGRFKKRFMYPVGYGLPAF 467

  Fly   363 GIALVFLAFTYCAQQLTNLPANLKPGIGDGVYCWLDMSN---WAAMIYFYGPILAIVVANTIMFI 424
            .:|:..:|.              ....|...:|||.:..   |:    |.||..||::.|.:.:.
Mouse   468 IVAVSAIAG--------------HKNYGTHNHCWLSLHRGFIWS----FLGPAAAIILINLVFYF 514

  Fly   425 MTAIKIHGVQREMARIIASENST--KNLRTEKDKRFYRAWSNYRFGLFLRLFLIMGITWLTELIS 487
            :           :..|:.|:.|:  |.:.|.:|.:.      ..|...::|| ::|.:|   .|.
Mouse   515 L-----------IIWILRSKLSSLNKEVSTLQDTKV------MTFKAIVQLF-VLGCSW---GIG 558

  Fly   488 YFVGSDKGWSK---LFYISDLANAMQGFLIFMLFVMKKKVKHLITNRCSSVRDGSNQRQSQY--- 546
            .|:..:.|.:.   :.|:..:.|.:||.||||:        |.:.||         |.:.:|
Mouse   559 LFIFIEVGKTVRLIVAYLFTIINVLQGVLIFMV--------HCLLNR---------QVRMEYKKW 606

  Fly   547 ------STKTTSSSVANLSLHEK 563
                  ..::.|:.|::.:.|.|
Mouse   607 FHRLRKEVESESTEVSHSTTHTK 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl10	NP_788446.2	Methuselah_N	56..236	CDD:429053
		7tmB3_Methuselah-like	242..533	CDD:410632	61/307 (20%)
		TM helix 1	244..269	CDD:410632	3/24 (13%)
		TM helix 2	278..300	CDD:410632	2/21 (10%)
		TM helix 3	311..338	CDD:410632	3/29 (10%)
		TM helix 4	354..374	CDD:410632	5/22 (23%)
		TM helix 5	401..430	CDD:410632	7/31 (23%)
		TM helix 6	446..489	CDD:410632	10/44 (23%)
		TM helix 7	497..522	CDD:410632	8/27 (30%)
Adgre4	NP_631877.2	EGF_CA	77..>105	CDD:214542
		GAIN	<214..264	CDD:465137
		GPS	290..332	CDD:460350
		GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098	292..339
		7tm_GPCRs	345..609	CDD:475119	62/325 (19%)
		TM helix 1	346..370	CDD:410628	3/23 (13%)
		TM helix 2	379..400	CDD:410628	3/26 (12%)
		TM helix 3	410..432	CDD:410628	2/21 (10%)
		TM helix 4	456..472	CDD:410628	4/15 (27%)
		TM helix 5	491..514	CDD:410628	7/26 (27%)
		TM helix 6	541..566	CDD:410628	7/28 (25%)
		TM helix 7	571..596	CDD:410628	9/32 (28%)