DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl10 and mthl2

DIOPT Version :9

Sequence 1:	NP_788446.2	Gene:	mthl10 / 38057	FlyBaseID:	FBgn0035132	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_788462.2	Gene:	mthl2 / 38636	FlyBaseID:	FBgn0035623	Length:	518	Species:	Drosophila melanogaster

Alignment Length:	507	Identity:	159/507 - (31%)
Similarity:	268/507 - (52%)	Gaps:	31/507 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 CNFYDTVNLTGHRLFPNGSYDYYGTIVPAELVGTYDYIHSSLTERIEVREHVRGCVCKFKSCLNI 120
            |:|||||:::..:...||||.|.|.::||.|...|::...:..::.:|..||||||||.::|:..
  Fly    31 CSFYDTVDISEGQRLSNGSYLYEGLLIPAHLTAKYEFKLLANGDKEQVPSHVRGCVCKLRTCVRF 95

  Fly   121 CCPWRQVFNSEVDGCIIDHSDNRTWPDPPMLNITFRNESTILVNMFTQFAIQ--SFRPCPKMFSL 183
            |||...:.  ::..|..:.:........||||:|..:.|.:..:...:..:|  ..:||..||.|
  Fly    96 CCPHDHIM--DMGECYANMTTEENELLDPMLNVTLDDGSVVQRHYKKELMVQWDLPKPCDDMFYL 158

  Fly   184 QPETNNWDDYLLFENGSMLRVDDKLLIRKNEFCMV-PTYVNESDMFYTIHPANCDMQDDHSTVKI 247
            . ..:..|:|.|||||.:||..|::.:.|:|:|:. .|:...::....|.|.||.:....:...:
  Fly   159 D-NRDIMDEYTLFENGRLLRHYDQVYLDKSEYCLQHRTFGEGNNNSIRIIPHNCLILPSRTGQTV 222

  Fly   248 INSYAMMFSIPFMMLTIAVYLLIPELRNQHGKSLVCYLIGLSVGYSSLCYVQLYQVDATGVTCKV 312
            :    |:.|:..::|||||||.:.:|.|..||..:||::.|..||..| .:.|:::...  .||.
  Fly   223 V----MITSLICLVLTIAVYLCVKKLMNLEGKCFICYMMCLFFGYLFL-LLDLWELSLD--FCKA 280

  Fly   313 FGYTAYFFFMGAYMWLSVISFDLWHNFRGTRGINRFQEKKRFLFYSLYSWGIALVFLAFTYCAQQ 377
            .|:..|||.|.|:.|||:||...|............:.::.||.||.::|.:.|.....||.|..
  Fly   281 AGFLGYFFVMAAFFWLSIISRHYWKCLTNPCASMNIRSERAFLLYSCFAWAMPLALTGVTYLADN 345

  Fly   378 LTNLPANLKPGIGDGVYCWLDMSNWAAMIYFYGPILAIVVANTIMFIMTAIKIHGVQREMARIIA 442
            :.| ....:|.:||..:||:...:|:||:|||||::.:::.|..||::||..|...:|.:.:|..
  Fly   346 VVN-NEEWQPRVGDEGHCWIYTKSWSAMVYFYGPMVLLILFNITMFVLTAKHIIDSKRTLRKIAR 409

  Fly   443 SENSTKNLRTEKDKRFYRAWSNYRFGLFLRLFLIMGITWLTELISYFVGSDKGWSKLFYISDLAN 507
            :|...:.|.::|        .||.  .||.||.:||::|..|:.||.|..:|.|..:|.::|..|
  Fly   410 NEGRIQKLNSDK--------QNYT--QFLLLFTVMGMSWSFEIFSYLVQREKLWVNIFLVADYFN 464

  Fly   508 AMQGFLIFMLFVMKKKVKHLITNRCSSVRDGSNQRQSQYSTKTTSSSVANLS 559
            ..||.:||:||::::|...|...:..       .:|..:|...|.|::.::|
  Fly   465 WSQGVIIFVLFILRRKTLVLFKKQIF-------PKQRAFSRSATQSTIESIS 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl10	NP_788446.2	Methuselah_N	56..236	CDD:284145	58/182 (32%)
mthl10	NP_788446.2	7tm_4	244..514	CDD:304433	88/269 (33%)
mthl2	NP_788462.2	Methuselah_N	31..211	CDD:284145	58/182 (32%)
mthl2	NP_788462.2	7tm_4	221..>395	CDD:304433	61/181 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5395
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.070