Protein Alignment mthl10 and mthl2

DIOPT Version :10

• Sequence 1: NP_788446.2
• Gene: mthl10 / 38057
• FlyBaseID: FBgn0035132
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_788462.2
• Gene: mthl2 / 38636
• FlyBaseID: FBgn0035623
• Length: 518
• Species: Drosophila melanogaster
• Alignment Length: 507
• Identity: 159/507 - (31%)
• Similarity: 268/507 - (52%)
• Gaps: 31/507 - (6%)

  Fly    56 CNFYDTVNLTGHRLFPNGSYDYYGTIVPAELVGTYDYIHSSLTERIEVREHVRGCVCKFKSCLNI 120
            |:|||||:::..:...||||.|.|.::||.|...|::...:..::.:|..||||||||.::|:..
  Fly    31 CSFYDTVDISEGQRLSNGSYLYEGLLIPAHLTAKYEFKLLANGDKEQVPSHVRGCVCKLRTCVRF 95

  Fly   121 CCPWRQVFNSEVDGCIIDHSDNRTWPDPPMLNITFRNESTILVNMFTQFAIQ--SFRPCPKMFSL 183
            |||...:.  ::..|..:.:........||||:|..:.|.:..:...:..:|  ..:||..||.|
  Fly    96 CCPHDHIM--DMGECYANMTTEENELLDPMLNVTLDDGSVVQRHYKKELMVQWDLPKPCDDMFYL 158

  Fly   184 QPETNNWDDYLLFENGSMLRVDDKLLIRKNEFCMV-PTYVNESDMFYTIHPANCDMQDDHSTVKI 247
            . ..:..|:|.|||||.:||..|::.:.|:|:|:. .|:...::....|.|.||.:....:...:
  Fly   159 D-NRDIMDEYTLFENGRLLRHYDQVYLDKSEYCLQHRTFGEGNNNSIRIIPHNCLILPSRTGQTV 222

  Fly   248 INSYAMMFSIPFMMLTIAVYLLIPELRNQHGKSLVCYLIGLSVGYSSLCYVQLYQVDATGVTCKV 312
            :    |:.|:..::|||||||.:.:|.|..||..:||::.|..||..| .:.|:::...  .||.
  Fly   223 V----MITSLICLVLTIAVYLCVKKLMNLEGKCFICYMMCLFFGYLFL-LLDLWELSLD--FCKA 280

  Fly   313 FGYTAYFFFMGAYMWLSVISFDLWHNFRGTRGINRFQEKKRFLFYSLYSWGIALVFLAFTYCAQQ 377
            .|:..|||.|.|:.|||:||...|............:.::.||.||.::|.:.|.....||.|..
  Fly   281 AGFLGYFFVMAAFFWLSIISRHYWKCLTNPCASMNIRSERAFLLYSCFAWAMPLALTGVTYLADN 345

  Fly   378 LTNLPANLKPGIGDGVYCWLDMSNWAAMIYFYGPILAIVVANTIMFIMTAIKIHGVQREMARIIA 442
            :.| ....:|.:||..:||:...:|:||:|||||::.:::.|..||::||..|...:|.:.:|..
  Fly   346 VVN-NEEWQPRVGDEGHCWIYTKSWSAMVYFYGPMVLLILFNITMFVLTAKHIIDSKRTLRKIAR 409

  Fly   443 SENSTKNLRTEKDKRFYRAWSNYRFGLFLRLFLIMGITWLTELISYFVGSDKGWSKLFYISDLAN 507
            :|...:.|.::|        .||.  .||.||.:||::|..|:.||.|..:|.|..:|.::|..|
  Fly   410 NEGRIQKLNSDK--------QNYT--QFLLLFTVMGMSWSFEIFSYLVQREKLWVNIFLVADYFN 464

  Fly   508 AMQGFLIFMLFVMKKKVKHLITNRCSSVRDGSNQRQSQYSTKTTSSSVANLS 559
            ..||.:||:||::::|...|...:..       .:|..:|...|.|::.::|
  Fly   465 WSQGVIIFVLFILRRKTLVLFKKQIF-------PKQRAFSRSATQSTIESIS 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl10	NP_788446.2	Methuselah_N	56..236	CDD:429053	58/182 (32%)
		7tmB3_Methuselah-like	242..533	CDD:410632	94/290 (32%)
		TM helix 1	244..269	CDD:410632	8/24 (33%)
		TM helix 2	278..300	CDD:410632	8/21 (38%)
		TM helix 3	311..338	CDD:410632	13/26 (50%)
		TM helix 4	354..374	CDD:410632	7/19 (37%)
		TM helix 5	401..430	CDD:410632	13/28 (46%)
		TM helix 6	446..489	CDD:410632	13/42 (31%)
		TM helix 7	497..522	CDD:410632	9/24 (38%)
mthl2	NP_788462.2	Methuselah_N	31..211	CDD:429053	58/182 (32%)
		7tmB3_Methuselah-like	215..489	CDD:410632	94/291 (32%)
		TM helix 1	215..240	CDD:410632	8/28 (29%)
		TM helix 2	249..269	CDD:410632	8/20 (40%)
		TM helix 3	279..306	CDD:410632	13/26 (50%)
		TM helix 4	322..342	CDD:410632	7/19 (37%)
		TM helix 5	367..397	CDD:410632	13/29 (45%)
		TM helix 6	419..446	CDD:410632	12/36 (33%)
		TM helix 7	454..479	CDD:410632	9/24 (38%)