DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl10 and mth

DIOPT Version :9

Sequence 1:	NP_788446.2	Gene:	mthl10 / 38057	FlyBaseID:	FBgn0035132	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_728521.1	Gene:	mth / 38058	FlyBaseID:	FBgn0023000	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	179/523 - (34%)
Similarity:	281/523 - (53%)	Gaps:	55/523 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 CNFYDTVNLTGHRLFPNGSYDYYGTIVPAELVGTYDYIHSSLTERIEVREHVRGCVCKFKSCLNI 120
            |:::|||:::..:...||||.:.|.:|||.|.|.||:.......:.:|..|:||||||.|.|:..
  Fly    29 CDYFDTVDISAAQKLQNGSYLFEGLLVPAILTGEYDFRILPDDSKQKVARHIRGCVCKLKPCVRF 93

  Fly   121 CCPWRQVFNSEVDGCIIDHSDNRTWPDPPMLNIT----------FRNESTILVNMFTQFAIQSFR 175
            |||...:.::.|  |..:.||.......|.||:|          |:||      :..|:.:.  .
  Fly    94 CCPHDHIMDNGV--CYDNMSDEELAELDPFLNVTLDDGSVSRRHFKNE------LIVQWDLP--M 148

  Fly   176 PCPKMFSLQPETNNWDDYLLFENGSMLRVDDKLLIRKNEFCMVP-TYVNESDMFYTIHPANCDMQ 239
            ||..||.|. .....|.|.|||||:..|..|::.:||.|:|:.. |:.:.:.....|.|.||.:.
  Fly   149 PCDGMFYLD-NREEQDKYTLFENGTFFRHFDRVTLRKREYCLQHLTFADGNATSIRIAPHNCLIV 212

  Fly   240 DDHSTVKIINSYAMMFSIPFMMLTIAVYLLIPELRNQHGKSLVCYLIGLSVGYSSLCYVQLYQVD 304
            ...:...::    |:.|:..|:|||||||.:.:|:|.|||..:||::.|.:||..| .:.|:|:.
  Fly   213 PSITGQTVV----MISSLICMVLTIAVYLFVKKLQNLHGKCFICYMVCLFMGYLFL-LLDLWQIS 272

  Fly   305 ATGVTCKVFGYTAYFFFMGAYMWLSVISFDLWHNFRG-TRGINRFQEKKRFLFYSLYSWGIALVF 368
            .:  .||..|:..|||.|.|:.||||||..||:.||| :...|||..:.|||.|:.|:||:|:|.
  Fly   273 IS--FCKPAGFLGYFFVMAAFFWLSVISLHLWNTFRGSSHKANRFLFEHRFLAYNTYAWGMAVVL 335

  Fly   369 LAFTYCAQQLTNLPANLKPGIGDGVYCWLDMSNWAAMIYFYGPILAIVVANTIMFIMTAIKIHGV 433
            ...|..|..:.. ..:..|.:|...:||:....|:||:|||||::.::..|..|||:||.:|.||
  Fly   336 TGITVLADNIVE-NQDWNPRVGHEGHCWIYTQAWSAMLYFYGPMVFLIAFNITMFILTAKRILGV 399

  Fly   434 QREMARIIASENSTKNLRTEKDKRFYRAWSNYRFGLFLRLFLIMGITWLTELISYFVGSDKGWSK 498
            ::::......:...:.|.::|        ..|.|  |||||:|||::|..|:.|||..|::.|:.
  Fly   400 KKDIQNFAHRQERKQKLNSDK--------QTYTF--FLRLFIIMGLSWSLEIGSYFSQSNQTWAN 454

  Fly   499 LFYISDLANAMQGFLIFMLFVMKKKVKHLITNRCSSVRDGSNQRQSQYSTKTTSSSVANLSLHEK 563
            :|.::|..|..||.:||:|||:|:....|:              |.:...|:|.|.::|.|:..:
  Fly   455 VFLVADYLNWSQGIIIFILFVLKRSTWRLL--------------QERNHPKSTRSVISNRSMASR 505

  Fly   564 PSV 566
            .:|
  Fly   506 ITV 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl10	NP_788446.2	Methuselah_N	56..236	CDD:284145	62/190 (33%)
mthl10	NP_788446.2	7tm_4	244..514	CDD:304433	101/270 (37%)
mth	NP_728521.1	Methuselah_N	29..209	CDD:284145	62/190 (33%)
mth	NP_728521.1	7tm_4	219..416	CDD:304433	77/204 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5395
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	1	1.000	-	-		mtm9601
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	7.070